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Samuel Edwin Weir (March 14, 1903 – May 15, 1991) was an American collegiate and professional football player. He was the first Nebraska Cornhuskers football player elected to the College Football Hall of Fame and is known as one of Nebraska's greatest athletes. In 2005 the Omaha World-Herald, as part of a series on the 100 Greatest Athletes of Nebraska, named Weir the 19th best athlete in the state's history.