About: EGIS-7625

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

EGIS-7625 is a selective and competitive 5-HT2B receptor antagonist. It is experimentally proven to be directly associated with smooth stomach muscle constriction of white rats in vivo, and variably effective in provoking a similar response in in vitro human stomach cells. In high blood concentrations, it causes mild constriction of rabbit pulmonary arteries.

Property	Value
dbo:abstract	EGIS-7625 is a selective and competitive 5-HT2B receptor antagonist. It is experimentally proven to be directly associated with smooth stomach muscle constriction of white rats in vivo, and variably effective in provoking a similar response in in vitro human stomach cells. In high blood concentrations, it causes mild constriction of rabbit pulmonary arteries. (en)
dbo:casNumber	755040-97-2
dbo:fdaUniiCode	VVM6OT854G
dbo:pubchem	9930789
dbo:thumbnail	wiki-commons:Special:FilePath/EGIS-7625.svg?width=300
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dbo:wikiPageWikiLink	dbr:In_vitro dbr:In_vivo dbc:Piperazines dbr:Pulmonary_artery dbr:Receptor_antagonist dbr:5-HT2B_receptor dbc:Anilines dbc:5-HT2_antagonists
dbp:atcPrefix	none (en)
dbp:c	18 (xsd:integer)
dbp:casNumber	755040 (xsd:integer)
dbp:chemspiderid	8106420 (xsd:integer)
dbp:h	22 (xsd:integer)
dbp:iupacName	5 (xsd:integer)
dbp:legalUn	Unscheduled (en)
dbp:n	4 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pubchem	9930789 (xsd:integer)
dbp:smiles	CC1=CC[N+][O-] (en)
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dbp:stdinchikey	ZEFXWOMFCPRXJW-UHFFFAOYSA-N (en)
dbp:unii	VVM6OT854G (en)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Nervous-system-drug-stub dbt:Piperazines dbt:Reflist dbt:Serotonergics dbt:Short_description dbt:Fdacite
dcterms:subject	dbc:Piperazines dbc:Anilines dbc:5-HT2_antagonists
gold:hypernym	dbr:Antagonist
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rdfs:comment	EGIS-7625 is a selective and competitive 5-HT2B receptor antagonist. It is experimentally proven to be directly associated with smooth stomach muscle constriction of white rats in vivo, and variably effective in provoking a similar response in in vitro human stomach cells. In high blood concentrations, it causes mild constriction of rabbit pulmonary arteries. (en)
rdfs:label	EGIS-7625 (en)
owl:sameAs	freebase:EGIS-7625 yago-res:EGIS-7625 wikidata:EGIS-7625 https://global.dbpedia.org/id/4if66
prov:wasDerivedFrom	wikipedia-en:EGIS-7625?oldid=1110171449&ns=0
foaf:depiction	wiki-commons:Special:FilePath/EGIS-7625.svg
foaf:isPrimaryTopicOf	wikipedia-en:EGIS-7625
is dbo:wikiPageWikiLink of	dbr:C18H22N4O2 dbr:5-HT2B_receptor dbr:Piperazine
is foaf:primaryTopic of	wikipedia-en:EGIS-7625