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- In enzymology, a 4-hydroxyphenylacetate 1-monooxygenase (EC 1.14.13.18) is an enzyme that catalyzes the chemical reaction 4-hydroxyphenylacetate + NAD(P)H + H+ + O2 homogentisate + NAD(P)+ + H2O The 5 substrates of this enzyme are 4-hydroxyphenylacetate, NADH, NADPH, H+, and O2, whereas its 4 products are homogentisate, NAD+, NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating). Other names in common use include 4-hydroxyphenylacetate 1-hydroxylase, 4-hydroxyphenylacetic 1-hydroxylase, and 4-HPA 1-hydroxylase. This enzyme participates in tyrosine metabolism.. It employs one cofactor, FAD. (en)
- La 4-idrossifenilacetato 1-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 4-idrossifenilacetato + NAD(P)H + H+ + O2 ⇄ + NAD(P)+ + H2O L'enzima è una flavoproteina (FAD). Agisce anche sul 4-idrossi (generando 2-metilomogentisato) e sul 4-idrossifenossiacetato (generando idrochinone e glicolato). (it)
- 4-ヒドロキシフェニル酢酸-1-モノオキシゲナーゼ（4-hydroxyphenylacetate 1-monooxygenase）は、チロシン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 4-ヒドロキシフェニル酢酸 + NAD(P)H + H+ + O2 ホモゲンチジン酸 + NAD(P)+ + H2O この酵素の基質は4-ヒドロキシフェニル酢酸、NADH（NADPH）、H+とO2で、生成物はホモゲンチジン酸、NAD(P)+とH2Oである。補酵素としてFADを用いる。 組織名は4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)で、別名に4-hydroxyphenylacetate 1-hydroxylase、4-hydroxyphenylacetic 1-hydroxylase、4-HPA 1-hydroxylaseがある。 (ja)
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- La 4-idrossifenilacetato 1-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 4-idrossifenilacetato + NAD(P)H + H+ + O2 ⇄ + NAD(P)+ + H2O L'enzima è una flavoproteina (FAD). Agisce anche sul 4-idrossi (generando 2-metilomogentisato) e sul 4-idrossifenossiacetato (generando idrochinone e glicolato). (it)
- 4-ヒドロキシフェニル酢酸-1-モノオキシゲナーゼ（4-hydroxyphenylacetate 1-monooxygenase）は、チロシン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 4-ヒドロキシフェニル酢酸 + NAD(P)H + H+ + O2 ホモゲンチジン酸 + NAD(P)+ + H2O この酵素の基質は4-ヒドロキシフェニル酢酸、NADH（NADPH）、H+とO2で、生成物はホモゲンチジン酸、NAD(P)+とH2Oである。補酵素としてFADを用いる。 組織名は4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)で、別名に4-hydroxyphenylacetate 1-hydroxylase、4-hydroxyphenylacetic 1-hydroxylase、4-HPA 1-hydroxylaseがある。 (ja)
- In enzymology, a 4-hydroxyphenylacetate 1-monooxygenase (EC 1.14.13.18) is an enzyme that catalyzes the chemical reaction 4-hydroxyphenylacetate + NAD(P)H + H+ + O2 homogentisate + NAD(P)+ + H2O The 5 substrates of this enzyme are 4-hydroxyphenylacetate, NADH, NADPH, H+, and O2, whereas its 4 products are homogentisate, NAD+, NADP+, and H2O. (en)
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- 4-hydroxyphenylacetate 1-monooxygenase (en)
- 4-idrossifenilacetato 1-monoossigenasi (it)
- 4-ヒドロキシフェニル酢酸-1-モノオキシゲナーゼ (ja)
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- 4-hydroxyphenylacetate 1-monooxygenase (en)
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