Dog appeasing pheromone (DAP), sometimes known as apasine, is a mixture of esters of fatty acids released by the sebaceous glands in the inter-mammary sulcus of lactating female dogs. It is secreted from between three and four days after parturition and two to five days after weaning. DAP is believed to be detected by the vomeronasal organ (Jacobson's organ) and has an appeasing effect on both adults and pups, and assists in establishing a bond with the mother. Synthetic DAP analogues have been developed which may support dogs during some, but not all, stressful situations.
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