About: Deoxyhypusine synthase

An Entity of Type: enzyme, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Deoxyhypusine synthase (EC 2.5.1.46, spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)) is an enzyme with systematic name (eIF5A-precursor)-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity.

Property	Value
dbo:abstract	Deoxyhypusine synthase (EC 2.5.1.46, spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)) is an enzyme with systematic name (eIF5A-precursor)-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction [eIF5A-precursor]-lysine + spermidine [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine (overall reaction)(1a) spermidine + NAD+ dehydrospermidine + NADH(1b) + [enzyme]-lysine N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine(1c) N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine(1d) N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ [eIF5A-precursor]-deoxyhypusine + NAD+ The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. (en)
dbo:ecNumber	2.5.1.46
dbo:wikiPageID	38847525 (xsd:integer)
dbo:wikiPageLength	4920 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1040845113 (xsd:integer)
dbo:wikiPageWikiLink	dbr:List_of_enzymes dbr:Hypusine dbc:EC_2.5.1 dbr:Chemical_reaction dbr:Enzyme dbr:Spermidine dbr:Catalysis dbr:Dehydrospermidine
dbp:casNumber	127069 (xsd:integer)
dbp:ecNumber	2.500000 (xsd:double)
dbp:iubmbEcNumber	2 (xsd:integer)
dbp:name	Deoxyhypusine synthase (en)
dbp:wikiPageUsesTemplate	dbt:Alkyl_and_aryl_transferases dbt:EC_number dbt:Enzymes dbt:Infobox_enzyme dbt:MeshName dbt:Portal_bar dbt:Reflist
dcterms:subject	dbc:EC_2.5.1
rdf:type	owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:comment	Deoxyhypusine synthase (EC 2.5.1.46, spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)) is an enzyme with systematic name (eIF5A-precursor)-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. (en)
rdfs:label	Deoxyhypusine synthase (en)
owl:sameAs	freebase:Deoxyhypusine synthase wikidata:Deoxyhypusine synthase wikidata:Deoxyhypusine synthase https://global.dbpedia.org/id/21S8C
prov:wasDerivedFrom	wikipedia-en:Deoxyhypusine_synthase?oldid=1040845113&ns=0
foaf:isPrimaryTopicOf	wikipedia-en:Deoxyhypusine_synthase
foaf:name	Deoxyhypusine synthase (en)
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is dbo:wikiPageWikiLink of	dbr:List_of_EC_numbers_(EC_2) dbr:Thomas_Hartmann_(biologist) dbr:EC_2.5.1.46 dbr:(eIF5A-precursor)-lysine:spermidine_4-...sferase_(propane-1,3-diamine-forming) dbr:Spermidine:eIF5A-lysine_4-aminobutyltransferase_(propane-1,3-diamine-forming)
is foaf:primaryTopic of	wikipedia-en:Deoxyhypusine_synthase