| dbo:abstract
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- Deltorphin, also known as deltorphin A and dermenkephalin, is a naturally occurring, exogenous opioid heptapeptide and thus, exorphin, with the amino acid sequence Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2. Along with the other deltorphins (such as deltorphin I and ) and the dermorphins, deltorphin is endogenous to frogs of the genus Phyllomedusa such as P. bicolor and P. sauvagei where it is produced in their skin, and is not known to occur naturally in any other species. Deltorphin is one of the highest affinity and most selective naturally occurring opioid peptides known, acting as a very potent and highly specific agonist of the δ-opioid receptor. Deltorphins have an unusually high blood–brain barrier penetration rate. The nonselective opiate antagonist naloxone inhibits deltorphin uptake by brain microvessels, but neither the selective δ-opioid antagonist naltrindole nor a number of opioid peptides with different affinities for δ- or μ-opioid receptors compete with deltorphins for the transport. (en)
- La Deltorfina, conosciuta anche come deltorfina A e dermencefalina, è un peptide oppioide naturale esogeno, con sequenza peptidica Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2. Come le altre deltorfine ( e ) e le dermomorfine, la deltorfina è endogena di alcune rane del genere Phyllomedusa, come la Phyllomedusa bicolor e la , contenuta delle secrezioni epidermiche. (it)
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- Deltorphin A; Dermenkephalin (en)
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| dbo:iupacName
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- or (en)
- (L)-tyrosyl-(D)-methionyl-(L)-phenylalanyl-(L)-histidyl-(L)-leucyl-(L)-methionyl-(L)-α-asparagine (en)
- (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-4-(methylsulfanyl)butanamido]-3-phenylpropanamido]-3-(1H-imidazol-4-yl)propanamido]-4-methylpentanamido]-4-(methylsulfanyl)butanamido]-3-carbamoylpropanoic acid (en)
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- 5821 (xsd:nonNegativeInteger)
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- -3 (xsd:integer)
- or (en)
- (L)-tyrosyl-(D)-methionyl-(L)-phenylalanyl-(L)-histidyl-(L)-leucyl-(L)-methionyl-(L)-α-asparagine (en)
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- Deltorphin A; Dermenkephalin (en)
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| rdfs:comment
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- La Deltorfina, conosciuta anche come deltorfina A e dermencefalina, è un peptide oppioide naturale esogeno, con sequenza peptidica Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2. Come le altre deltorfine ( e ) e le dermomorfine, la deltorfina è endogena di alcune rane del genere Phyllomedusa, come la Phyllomedusa bicolor e la , contenuta delle secrezioni epidermiche. (it)
- Deltorphin, also known as deltorphin A and dermenkephalin, is a naturally occurring, exogenous opioid heptapeptide and thus, exorphin, with the amino acid sequence Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2. Along with the other deltorphins (such as deltorphin I and ) and the dermorphins, deltorphin is endogenous to frogs of the genus Phyllomedusa such as P. bicolor and P. sauvagei where it is produced in their skin, and is not known to occur naturally in any other species. Deltorphin is one of the highest affinity and most selective naturally occurring opioid peptides known, acting as a very potent and highly specific agonist of the δ-opioid receptor. (en)
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| rdfs:label
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- Deltorphin (en)
- Deltorfina (it)
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