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- Die Darzens-Halogenierung, benannt nach dem französischen Chemiker A. G. Darzens ist eine Namensreaktion aus der organischen Chemie und wurde erstmals 1911 veröffentlicht. Die Reaktion beschreibt die Synthese von Halogenkohlenwasserstoffen aus Alkoholen. (de)
- Darzens halogenation is the chemical synthesis of alkyl halides from alcohols via the treatment upon reflux of a large excess of thionyl chloride or thionyl bromide (SOX2) in the presence of a small amount of a nitrogen base, such as a tertiary amine or pyridine or its corresponding hydrochloride or hydrobromide salt. The reaction is named after its creator, Auguste Georges Darzens, who first reported it in 1911. The addition of the amine and use of a large excess of the thionyl halide as compared to the usual halogenation protocol makes this reaction effective for a wide range of alcohols including those that are difficult to halogenate, such as cyclohexanol, which normally decomposes to form cyclohexene if reacted with only SOCl2. The reaction takes place through an SN2 mechanism but is also often used in the description of SNi mechanisms. For example, ethanol can be converted into chloroethane (X=Cl) or bromoethane (X=Br) as follows: CH3CH2OH + SOX2 CH3CH2X + SO2 + HX (en)
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- Die Darzens-Halogenierung, benannt nach dem französischen Chemiker A. G. Darzens ist eine Namensreaktion aus der organischen Chemie und wurde erstmals 1911 veröffentlicht. Die Reaktion beschreibt die Synthese von Halogenkohlenwasserstoffen aus Alkoholen. (de)
- Darzens halogenation is the chemical synthesis of alkyl halides from alcohols via the treatment upon reflux of a large excess of thionyl chloride or thionyl bromide (SOX2) in the presence of a small amount of a nitrogen base, such as a tertiary amine or pyridine or its corresponding hydrochloride or hydrobromide salt. The reaction is named after its creator, Auguste Georges Darzens, who first reported it in 1911. For example, ethanol can be converted into chloroethane (X=Cl) or bromoethane (X=Br) as follows: CH3CH2OH + SOX2 CH3CH2X + SO2 + HX (en)
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- Darzens-Halogenierung (de)
- Darzens halogenation (en)
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