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- Cytochrome P450 aromatic O-demethylase is a bacterial enzyme that catalyzes the demethylation of lignin and various lignols. The net reaction follows the following stoichiometry, illustrated with a generic methoxy arene: ArOCH3 + O2 + 2 e− + 2 H+ → ArOH + CH2O + H2O The enzyme is notable for its promiscuity, it effects the O-demethylation of a range of substrates, including lignin. It is a heterodimeric protein derived from the products of two genes. The component proteins are a cytochrome P450 enzyme (encoded by the gcoA gene from the family CYP255A) and a three-domain reductase (encoded by the gcoB gene) complexed with three cofactors (2Fe-2S, FAD, and NADH). (en)
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- 8513 (xsd:nonNegativeInteger)
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- Crystal structure of gcoB complexed with FAD and an iron–sulfur cluster based on . (en)
- Crystal structure of gcoA in complex with heme and guaiacol based on . (en)
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- 1.140000 (xsd:double)
- 1.600000 (xsd:double)
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- Aromatic O-demethylase, cytochrome P450 subunit (en)
- Aromatic O-demethylase, reductase subunit (en)
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- Cytochrome P450 aromatic O-demethylase is a bacterial enzyme that catalyzes the demethylation of lignin and various lignols. The net reaction follows the following stoichiometry, illustrated with a generic methoxy arene: ArOCH3 + O2 + 2 e− + 2 H+ → ArOH + CH2O + H2O The enzyme is notable for its promiscuity, it effects the O-demethylation of a range of substrates, including lignin. (en)
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- Cytochrome P450 aromatic O-demethylase (en)
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