Comprehensive Therapy was a quarterly peer-reviewed medical journal covering clinical diagnosis, pharmacology, treatment, and disease management. It was established in 1975 and published by Humana Press until 2008, when the , of which it had been an official journal, took over. The journal was discontinued in 2010. It was abstracted and indexed in Index Medicus/MEDLINE/PubMed, CINAHL, and Scopus.