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- Chemical genetics is the investigation of the function of proteins and signal transduction pathways in cells by the screening of chemical libraries of small molecules. Chemical genetics is analogous to classical genetic screen where random mutations are introduced in organisms, the phenotype of these mutants is observed, and finally the specific gene mutation (genotype) that produced that phenotype is identified. In chemical genetics, the phenotype is disturbed not by introduction of mutations, but by exposure to small molecule tool compounds. Phenotypic screening of chemical libraries is used to identify drug targets (forward genetics or chemoproteomics) or to validate those targets in experimental models of disease (reverse genetics). Recent applications of this topic have been implicated in signal transduction, which may play a role in discovering new cancer treatments. Chemical genetics can serve as a unifying study between chemistry and biology. The approach was first proposed by Tim Mitchison in 1994 in an opinion piece in the journal Chemistry & Biology entitled "Towards a pharmacological genetics". (en)
- Хімічна генетика (англ. chemical genetics, рос. химическая генетика) — використання невеликих синтетичних молекул, що викликають певні зміни при прямій взаємодії з білками, з метою ідентифікації ключових генів, що включені в певний біологічний процес. (uk)
- 化学遗传学(Chemical genetics)是通过筛选小分子来研究细胞中蛋白质和訊息傳遞途径的功能。近年来应用高通量技术进行化学遗传学的筛选正越来越受到关注。化学遗传学类似于经典遗传筛选，在经典遗传学筛选中，随机突变被引入生物中，这些突变体的表型被观察到，并且最后产生该表型的特定基因突变（基因型）被鉴定出。 (zh)
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- Хімічна генетика (англ. chemical genetics, рос. химическая генетика) — використання невеликих синтетичних молекул, що викликають певні зміни при прямій взаємодії з білками, з метою ідентифікації ключових генів, що включені в певний біологічний процес. (uk)
- 化学遗传学(Chemical genetics)是通过筛选小分子来研究细胞中蛋白质和訊息傳遞途径的功能。近年来应用高通量技术进行化学遗传学的筛选正越来越受到关注。化学遗传学类似于经典遗传筛选，在经典遗传学筛选中，随机突变被引入生物中，这些突变体的表型被观察到，并且最后产生该表型的特定基因突变（基因型）被鉴定出。 (zh)
- Chemical genetics is the investigation of the function of proteins and signal transduction pathways in cells by the screening of chemical libraries of small molecules. Chemical genetics is analogous to classical genetic screen where random mutations are introduced in organisms, the phenotype of these mutants is observed, and finally the specific gene mutation (genotype) that produced that phenotype is identified. In chemical genetics, the phenotype is disturbed not by introduction of mutations, but by exposure to small molecule tool compounds. Phenotypic screening of chemical libraries is used to identify drug targets (forward genetics or chemoproteomics) or to validate those targets in experimental models of disease (reverse genetics). Recent applications of this topic have been implicate (en)
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- Chemical genetics (en)
- Хімічна генетика (uk)
- 化学遗传学 (zh)
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