About: Cas3

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Cas3 is an ATP-dependent single-strand DNA (ssDNA) translocase/helicase enzyme that degrades DNA as part of CRISPR based immunity. Cas3 is a "signature" protein of class 1 CRISPR systems and functions in a complex known as CASCADE, with other cas genes and a targeting RNA to degrade viral DNA. CONAN, a CRISPR based diagnostic approach was developed utilising Cas3

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  • Cas3 is an ATP-dependent single-strand DNA (ssDNA) translocase/helicase enzyme that degrades DNA as part of CRISPR based immunity. Cas3 is a "signature" protein of class 1 CRISPR systems and functions in a complex known as CASCADE, with other cas genes and a targeting RNA to degrade viral DNA. In April 2019 Cornell University researcher Ailong Ke published a paper in the journal Molecular Cell describing a new gene editing CRISPR system, CRISPR-Cas3 which can efficiently delete long swaths of DNA from a targeted site in the human genome. This ability is superior to that achieved with the more common CRISPR-Cas9 systems. CONAN, a CRISPR based diagnostic approach was developed utilising Cas3 (en)
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  • cas3
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  • IPR041372 (en)
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  • CRISPR-associated protein 3 (en)
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  • PF18395 (en)
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  • cas3 (en)
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  • Cas3 is an ATP-dependent single-strand DNA (ssDNA) translocase/helicase enzyme that degrades DNA as part of CRISPR based immunity. Cas3 is a "signature" protein of class 1 CRISPR systems and functions in a complex known as CASCADE, with other cas genes and a targeting RNA to degrade viral DNA. CONAN, a CRISPR based diagnostic approach was developed utilising Cas3 (en)
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  • Cas3 (en)
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