About: Cartilage-derived angiogenesis inhibitor

An Entity of Type: drug, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

A cartilage-derived angiogenesis inhibitor is an angiogenesis inhibitor produced from cartilage. Examples include the peptide troponin I and chondromodulin I.The antiangiogenic effect may be an inhibition of basement membrane degradation. These inhibitory agents prevent 'vascular invasion,' which is the proliferation of tumor cells in the blood or lymph vessels. They are usually highly expressed in cartilage and within chondrocytes. Their genetic transcription increases upon the expansion of cartilaginous regions.

Property Value
dbo:abstract
  • A cartilage-derived angiogenesis inhibitor is an angiogenesis inhibitor produced from cartilage. Examples include the peptide troponin I and chondromodulin I.The antiangiogenic effect may be an inhibition of basement membrane degradation. These inhibitory agents prevent 'vascular invasion,' which is the proliferation of tumor cells in the blood or lymph vessels. They are usually highly expressed in cartilage and within chondrocytes. Their genetic transcription increases upon the expansion of cartilaginous regions. Recent studies on Troponin I hypothesize that this protein performs its anti-proliferation effect on endothelial cells via interactions with a bFGF receptor. Neighboring studies on other anti-angiogenic factors are evolving, however, the general mechanism of action is still unknown today. (en)
dbo:wikiPageID
  • 15181461 (xsd:integer)
dbo:wikiPageLength
  • 2753 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1032084375 (xsd:integer)
dbo:wikiPageWikiLink
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • A cartilage-derived angiogenesis inhibitor is an angiogenesis inhibitor produced from cartilage. Examples include the peptide troponin I and chondromodulin I.The antiangiogenic effect may be an inhibition of basement membrane degradation. These inhibitory agents prevent 'vascular invasion,' which is the proliferation of tumor cells in the blood or lymph vessels. They are usually highly expressed in cartilage and within chondrocytes. Their genetic transcription increases upon the expansion of cartilaginous regions. (en)
rdfs:label
  • Cartilage-derived angiogenesis inhibitor (en)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageDisambiguates of
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License