About: Cabot–Locke murmur

An Entity of Type: disease, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

A Cabot–Locke murmur is an early diastolic heart murmur, occasionally heard in severe untreated anemia, without heart valve abnormalities. It is detected infrequently, is best heard at the left sternal border, and sounds similar to aortic insufficiency, although it is without decrescendo. Its location, timing, association with severe anemia, and resolution upon correction of anemia, are consistent mechanistically with a functional murmur arising from high volume flow dynamics in the left main coronary artery, which has almost entirely diastolic flow.

Property Value
dbo:abstract
  • A Cabot–Locke murmur is an early diastolic heart murmur, occasionally heard in severe untreated anemia, without heart valve abnormalities. It is detected infrequently, is best heard at the left sternal border, and sounds similar to aortic insufficiency, although it is without decrescendo. Its location, timing, association with severe anemia, and resolution upon correction of anemia, are consistent mechanistically with a functional murmur arising from high volume flow dynamics in the left main coronary artery, which has almost entirely diastolic flow. It is named for Richard Clarke Cabot and his colleague, Locke. They reported on a series of three patients who had been clinically diagnosed with heart valve disease, but who had normal valvular anatomy at subsequent autopsy. (en)
dbo:wikiPageID
  • 31410208 (xsd:integer)
dbo:wikiPageLength
  • 1756 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 913213140 (xsd:integer)
dbo:wikiPageWikiLink
dbp:differential
  • severe anemia (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • A Cabot–Locke murmur is an early diastolic heart murmur, occasionally heard in severe untreated anemia, without heart valve abnormalities. It is detected infrequently, is best heard at the left sternal border, and sounds similar to aortic insufficiency, although it is without decrescendo. Its location, timing, association with severe anemia, and resolution upon correction of anemia, are consistent mechanistically with a functional murmur arising from high volume flow dynamics in the left main coronary artery, which has almost entirely diastolic flow. (en)
rdfs:label
  • Cabot–Locke murmur (en)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License