| dbo:abstract
|
- Apatinib, also known as rivoceranib, is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR). It is an orally bioavailable, small molecule agent which is thought to inhibit angiogenesis in cancer cells; specifically, apatinib inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. This agent also mildly inhibits c-Kit and c-SRC tyrosine kinases. Apatinib was first synthesized by Advenchen Laboratories in California, USA and licensed out global rights to HLB (Korea) in 2020 and is being developed by Jiangsu Hengrui Medicine (China), LSK BioPartners (US) and HLB Life Science (Korea). It is an investigational cancer drug currently undergoing clinical trials as a potential targeted treatment for metastatic gastric carcinoma, metastatic breast cancer, adenoid cystic carcinoma, and advanced hepatocellular carcinoma. (en)
- 阿帕替尼（apatinib），又名Rivoceranib ，中國大陸商品名為艾坦，是一种口服小分子酪氨酸激酶抑制剂，可选择性抑制血管内皮生长因子受体-2（VEGFR2，又称KDR），认为可以抑制癌细胞中的血管新生。阿帕替尼抑制 VEGF 導致的内皮细胞迁移和增殖，進而阻止肿瘤组织中新血管的形成。本藥物對於 c-Kit 和 c-SRC 酪氨酸激酶也有輕微的抑制效果。 阿帕替尼首先由美国加利福尼亚州的 Advenchen Laboratories 合成，于 2020 年將全球權利授權給韓國的 HLB，目前由中國江苏恒瑞医药、美國LSK BioPartners、韓國HLB 生命科学繼續开发。 临床试验目標為針對转移性胃癌、转移性乳癌和晚期肝细胞癌的標靶治療。 (zh)
|
| dbo:casNumber
| |
| dbo:drugbank
| |
| dbo:fdaUniiCode
| |
| dbo:pubchem
| |
| dbo:thumbnail
| |
| dbo:wikiPageID
| |
| dbo:wikiPageLength
|
- 7877 (xsd:nonNegativeInteger)
|
| dbo:wikiPageRevisionID
| |
| dbo:wikiPageWikiLink
| |
| dbp:atcPrefix
| |
| dbp:c
| |
| dbp:casNumber
| |
| dbp:chemspiderid
| |
| dbp:drugbank
| |
| dbp:h
| |
| dbp:iupacName
| |
| dbp:n
| |
| dbp:o
| |
| dbp:pubchem
| |
| dbp:routesOfAdministration
| |
| dbp:smiles
| |
| dbp:stdinchi
| |
| dbp:stdinchikey
|
- WPEWQEMJFLWMLV-UHFFFAOYSA-N (en)
|
| dbp:synonyms
|
- Rivoceranib; YN968D1 (en)
|
| dbp:unii
| |
| dbp:verifiedrevid
| |
| dbp:width
| |
| dbp:wikiPageUsesTemplate
| |
| dcterms:subject
| |
| gold:hypernym
| |
| rdf:type
| |
| rdfs:comment
|
- 阿帕替尼（apatinib），又名Rivoceranib ，中國大陸商品名為艾坦，是一种口服小分子酪氨酸激酶抑制剂，可选择性抑制血管内皮生长因子受体-2（VEGFR2，又称KDR），认为可以抑制癌细胞中的血管新生。阿帕替尼抑制 VEGF 導致的内皮细胞迁移和增殖，進而阻止肿瘤组织中新血管的形成。本藥物對於 c-Kit 和 c-SRC 酪氨酸激酶也有輕微的抑制效果。 阿帕替尼首先由美国加利福尼亚州的 Advenchen Laboratories 合成，于 2020 年將全球權利授權給韓國的 HLB，目前由中國江苏恒瑞医药、美國LSK BioPartners、韓國HLB 生命科学繼續开发。 临床试验目標為針對转移性胃癌、转移性乳癌和晚期肝细胞癌的標靶治療。 (zh)
- Apatinib, also known as rivoceranib, is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR). It is an orally bioavailable, small molecule agent which is thought to inhibit angiogenesis in cancer cells; specifically, apatinib inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. This agent also mildly inhibits c-Kit and c-SRC tyrosine kinases. (en)
|
| rdfs:label
| |
| owl:differentFrom
| |
| owl:sameAs
| |
| prov:wasDerivedFrom
| |
| foaf:depiction
| |
| foaf:isPrimaryTopicOf
| |
| is dbo:wikiPageRedirects
of | |
| is dbo:wikiPageWikiLink
of | |
| is owl:differentFrom
of | |
| is foaf:primaryTopic
of | |
