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- BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof. BxPC-3 cells were derived from a 61-year-old female in 1986, and were confirmed to be tumorigenic in athymic nude mice, with moderate differentiation. The cells produce mucin, and exhibit an epithelial morphology. BxPC-3 cells lack a KRAS mutation, though it is commonly found in pancreatic cancers. BcPC-3 cells, along with JoPaca-1 cells, have high expression of cancer stem cell markers. BxPC-3 has been used in tumorigenicity studies, pancreatic cancer therapy research, and other biomedical applications. The cells have been additionally studied for their phenotypic and genotypic properties as they can be applied to pancreatic cancer drug development; in particular, BxPC-3 cells have high expression of the angiogenic factors IL-8, VEGF, and PGE2, which can serve as potential drug targets. (en)
- BxPC-3 (BxPC3）是用於研究胰腺癌及其治療方法的人類胰腺癌細胞系。BxPC-3細胞是在1986年從一個已61歲的人类女性體內獲得，並且被證實在無胸腺裸鼠中具有致瘤性，具有中等分化能力，同時又會產生粘蛋白，並且表現出上皮組織形態。BxPC-3細胞不會發生在胰腺癌中常見的突變。BcPC-3細胞和JoPaca-1細胞均有高表達的癌。BxPC-3目前已用於致瘤研究、胰腺癌治療研究及其他生物醫學應用中。 由於細胞可幫助胰腺癌藥物的開發，因此有學者對細胞的表型和基因型特性進行研究，特別是因為BxPC-3細胞具有血管生成因子IL-8、血管內皮生長因子和前列腺素E2的高度表達，故而可以作為潛在的藥物靶標。 (zh)
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- 2907 (xsd:nonNegativeInteger)
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- BxPC-3 (BxPC3）是用於研究胰腺癌及其治療方法的人類胰腺癌細胞系。BxPC-3細胞是在1986年從一個已61歲的人类女性體內獲得，並且被證實在無胸腺裸鼠中具有致瘤性，具有中等分化能力，同時又會產生粘蛋白，並且表現出上皮組織形態。BxPC-3細胞不會發生在胰腺癌中常見的突變。BcPC-3細胞和JoPaca-1細胞均有高表達的癌。BxPC-3目前已用於致瘤研究、胰腺癌治療研究及其他生物醫學應用中。 由於細胞可幫助胰腺癌藥物的開發，因此有學者對細胞的表型和基因型特性進行研究，特別是因為BxPC-3細胞具有血管生成因子IL-8、血管內皮生長因子和前列腺素E2的高度表達，故而可以作為潛在的藥物靶標。 (zh)
- BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof. BxPC-3 cells were derived from a 61-year-old female in 1986, and were confirmed to be tumorigenic in athymic nude mice, with moderate differentiation. The cells produce mucin, and exhibit an epithelial morphology. BxPC-3 cells lack a KRAS mutation, though it is commonly found in pancreatic cancers. BcPC-3 cells, along with JoPaca-1 cells, have high expression of cancer stem cell markers. (en)
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- BxPC-3 (en)
- BxPC-3細胞 (zh)
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