About: Bouvardin

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Bouvardin is a bicyclic hexapeptide isolated from Bouvardia ternifolia. Its chemical formula is C40H48N6O10. It is derived from the amino acid sequence Ala-Ala-Tyr-Ala-Tyr-Tyr. It has demonstrated certain anti-cancerous activities by inhibiting protein synthesis through inhibition of 80S ribosomes (eukaryotic ribosomes). The synthetic derivative of bouvardin SVC112 suppresses cancer stem cells and inhibits growth in head and neck squamous cell carcinoma.

Property	Value
dbo:abstract	Bouvardin is a bicyclic hexapeptide isolated from Bouvardia ternifolia. Its chemical formula is C40H48N6O10. It is derived from the amino acid sequence Ala-Ala-Tyr-Ala-Tyr-Tyr. It has demonstrated certain anti-cancerous activities by inhibiting protein synthesis through inhibition of 80S ribosomes (eukaryotic ribosomes). The synthetic derivative of bouvardin SVC112 suppresses cancer stem cells and inhibits growth in head and neck squamous cell carcinoma. (en)
dbo:iupacName	(1S,4R,7S,10S,13S,16S,17S)-17,24-Dihydroxy-10-(4-methoxybenzyl)-4,7,9,13,15,29-hexamethyl-22-oxa-3,6,9,12,15,29-hexaazatetracyclo[14.12.2.218,21.123,27]tritriaconta-18,20,23(31),24,26,32-hexaene-2,5,8,11,14,30-hexone (en)
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dbo:wikiPageWikiLink	dbr:Cancer dbr:Carbon dbr:Nitrogen dbr:Hydrogen dbr:Peptide dbr:Bouvardia_ternifolia dbr:Stem_cell dbr:Tyrosine dbr:Alanine dbr:Amino_acid dbr:Eukaryote dbr:Oxygen dbc:Cyclic_peptides dbc:Hexapeptides dbr:Ribosome dbr:Squamous_cell_carcinoma
dbp:imagefile	Bouvardin.svg (en)
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rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound
rdfs:comment	Bouvardin is a bicyclic hexapeptide isolated from Bouvardia ternifolia. Its chemical formula is C40H48N6O10. It is derived from the amino acid sequence Ala-Ala-Tyr-Ala-Tyr-Tyr. It has demonstrated certain anti-cancerous activities by inhibiting protein synthesis through inhibition of 80S ribosomes (eukaryotic ribosomes). The synthetic derivative of bouvardin SVC112 suppresses cancer stem cells and inhibits growth in head and neck squamous cell carcinoma. (en)
rdfs:label	Bouvardin (en)
owl:sameAs	wikidata:Bouvardin https://global.dbpedia.org/id/2YDfm
prov:wasDerivedFrom	wikipedia-en:Bouvardin?oldid=1096224749&ns=0
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foaf:isPrimaryTopicOf	wikipedia-en:Bouvardin
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is foaf:primaryTopic of	wikipedia-en:Bouvardin