In enzymology, a biphenyl synthase (EC 2.3.1.177) is an enzyme that catalyzes the chemical reaction: 3 malonyl-CoA + benzoyl-CoA 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 Thus, the two substrates of this enzyme are malonyl-CoA and benzoyl-CoA, whereas its three products are CoA, , and CO2. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:benzoyl-CoA malonyltransferase. This enzyme is also called BIS.
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