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- B Cell Growth and Differentiation Factors (also known as BCGF and BCDF) are two important groups of soluble factors controlling the life cycle of B cells (also referred to as B lymphocytes, cells which perform functions including: antibody secretion, antigen presentation, preservation of memory for antigens, and lymphokine secretion). BCGFs specifically mediate the growth and division of B cells, or, in other words, the progression of B cells through their life cycle (cell cycle stages G1, S, G2). BCDFs control the advancement of a B cell progenitor or unmatured B cell to an adult immunoglobulin (Ig) secreting cell. Differentiation factors control cell fate and can sometimes cause matured cells to change lineage. Not all currently known BCGFs and BCDFs affect all B cell lineages and stages of the cell cycle in similar ways. Both BCGFs and BCDFs work on cells previously "activated" by factors such as anti-immunoglobulin (anti-Ig). BCGFs cause activated B cells to enlarge, express activation markers (ex. transferrin receptor) and enter the S phase (DNA synthesis phase) of the cell cycle. Meanwhile, BCDFs stimulate these cells to differentiate to mature Ig-secreting B cells. An important note is that B cell Proliferation Factors (BCPFs) also exist and are different from BCGFs. BCPFs make cells, which are not necessarily activated, more responsive to BCGFs and help maintain cell viability, whereas BCGFs direct and stimulate growth and division. This article will mention BCPFs and factors that induce proliferation, yet the main focus will remain on BCGFs and BCDFs. (en)
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- B Cell Growth and Differentiation Factors (also known as BCGF and BCDF) are two important groups of soluble factors controlling the life cycle of B cells (also referred to as B lymphocytes, cells which perform functions including: antibody secretion, antigen presentation, preservation of memory for antigens, and lymphokine secretion). BCGFs specifically mediate the growth and division of B cells, or, in other words, the progression of B cells through their life cycle (cell cycle stages G1, S, G2). BCDFs control the advancement of a B cell progenitor or unmatured B cell to an adult immunoglobulin (Ig) secreting cell. Differentiation factors control cell fate and can sometimes cause matured cells to change lineage. Not all currently known BCGFs and BCDFs affect all B cell lineages and stages (en)
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- B cell growth and differentiation factors (en)
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