About: Avapritinib

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Avapritinib, sold under the brand name Ayvakit among others, is a medication used for the treatment of advanced systemic mastocytosis and for the treatment of tumors due to one specific rare mutation: it is specifically intended for adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbor a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation. Avapritinib is a kinase inhibitor.

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dbo:abstract
  • Avapritinib, sold under the brand name Ayvakit among others, is a medication used for the treatment of advanced systemic mastocytosis and for the treatment of tumors due to one specific rare mutation: it is specifically intended for adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbor a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation. Common side effects include edema (swelling), nausea, fatigue/asthenia (abnormal physical weakness or lack of energy), cognitive impairment, vomiting, decreased appetite, diarrhea, hair color changes, increased lacrimation (secretion of tears), abdominal pain, constipation, rash and dizziness. Avapritinib is a kinase inhibitor. (en)
dbo:alternativeName
  • Ayvakit, Ayvakyt (en)
dbo:casNumber
  • 1703793-34-3
dbo:chEMBL
  • 4204794
dbo:drugbank
  • DB15233
dbo:fdaUniiCode
  • 513P80B4YJ
dbo:kegg
  • D11279
dbo:medlinePlus
  • a620013
dbo:pubchem
  • 118023034
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  • L01 (en)
dbp:atcSuffix
  • EX18 (en)
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  • 26 (xsd:integer)
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  • 1703793 (xsd:integer)
dbp:chembl
  • 4204794 (xsd:integer)
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  • 58828673 (xsd:integer)
dbp:class
  • Antineoplastic agents (en)
dbp:dailymedid
  • Avapritinib (en)
dbp:drugbank
  • DB15233 (en)
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  • 1 (xsd:integer)
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  • 27 (xsd:integer)
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dbp:kegg
  • D11279 (en)
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  • Rx-only (en)
dbp:legalUs
  • Rx-only (en)
dbp:licenceEu
  • yes (en)
dbp:licenceUs
  • Ayvakit (en)
dbp:medlineplus
  • a620013 (en)
dbp:n
  • 10 (xsd:integer)
dbp:pronounce
  • A va PRI ti nib (en)
dbp:pubchem
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dbp:synonyms
  • BLU-285, BLU285 (en)
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  • Ayvakit, Ayvakyt (en)
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  • 513 (xsd:integer)
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  • Avapritinib, sold under the brand name Ayvakit among others, is a medication used for the treatment of advanced systemic mastocytosis and for the treatment of tumors due to one specific rare mutation: it is specifically intended for adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbor a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation. Avapritinib is a kinase inhibitor. (en)
rdfs:label
  • Avapritinib (en)
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