About: Allorecognition

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Allorecognition is the ability of an individual organism to distinguish its own tissues from those of another. It manifests itself in the recognition of antigens expressed on the surface of cells of non-self origin. Allorecognition has been described in nearly all multicellular phyla. * Immune system, Immunology * Transplant rejection * Tissue typing * Major histocompatibility complex (MHC)

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  • Allorecognition is the ability of an individual organism to distinguish its own tissues from those of another. It manifests itself in the recognition of antigens expressed on the surface of cells of non-self origin. Allorecognition has been described in nearly all multicellular phyla. This article focuses on allorecognition from the standpoint of its significance in the evolution of multicellular organisms. For other articles which focus on its importance in medicine, molecular biology, and so forth, the following topics are recommended as well as those in the Categories links at the bottom of this page. * Immune system, Immunology * Transplant rejection * Tissue typing * Major histocompatibility complex (MHC) The ability to discriminate between self and non-self is a fundamental requirement for life. At the most basic level, even single-celled organisms need to be able to distinguish between food and non-food, to respond appropriately to invading pathogens, and to avoid cannibalism. In sexually reproducing organisms, self/non-self discrimination is essential to ensuring species-specific egg/sperm interaction during fertilization. Hermaphroditic organisms, such as annelids and certain plants, require recognition mechanisms to prevent self-fertilization. Such functions are all carried out by the innate immune system, which employs evolutionarily conserved pattern recognition receptors to eliminate cells displaying "nonself markers." (en)
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  • Allorecognition is the ability of an individual organism to distinguish its own tissues from those of another. It manifests itself in the recognition of antigens expressed on the surface of cells of non-self origin. Allorecognition has been described in nearly all multicellular phyla. * Immune system, Immunology * Transplant rejection * Tissue typing * Major histocompatibility complex (MHC) (en)
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  • Allorecognition (en)
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