About: Alazocine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Alazocine (developmental code name SKF-10047), also known more commonly as N-allylnormetazocine (NANM), is a synthetic opioid analgesic of the benzomorphan family related to metazocine, which was never marketed. In addition to its opioid activity, the drug is a sigma receptor agonist, and has been used widely in scientific research in studies of this receptor. Alazocine is described as a potent analgesic, psychotomimetic or hallucinogen, and opioid antagonist. Moreover, one of its enantiomers was the first compound that was found to selectively label the σ1 receptor, and led to the discovery and characterization of the receptor.

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dbo:abstract
  • Alazocine (developmental code name SKF-10047), also known more commonly as N-allylnormetazocine (NANM), is a synthetic opioid analgesic of the benzomorphan family related to metazocine, which was never marketed. In addition to its opioid activity, the drug is a sigma receptor agonist, and has been used widely in scientific research in studies of this receptor. Alazocine is described as a potent analgesic, psychotomimetic or hallucinogen, and opioid antagonist. Moreover, one of its enantiomers was the first compound that was found to selectively label the σ1 receptor, and led to the discovery and characterization of the receptor. (en)
  • アラゾシン（英: alazocine、開発コード: SKF-10047）は、と関連したベンゾモルファン系の合成オピオイド鎮痛剤であり、市販されたことはない。N-アリルノルメタゾシン（N-allylnormetazocine、NANM）の名称でも一般的に知られる。オピオイド活性に加えて、のアゴニストでもあり、この受容体の研究に広く利用されている。アラゾシンは強力な鎮痛剤、、幻覚剤、モルヒネ様物質、として記載されている。さらに、エナンチオマーの1つはを選択的に標識することが発見された最初の化合物であり、この受容体の発見と特徴づけを導いた。 (ja)
  • L'alazocina (noto nel corso del suo sviluppo con il nome di SKF -10047), noto anche più comunemente come N -allilnormetazocina ( NANM ), è un analgesico oppiaceo sintetico della famiglia benzomorpana correlato alla metazocina, che non è mai stato commercializzato. Oltre alla sua attività oppioide, il farmaco è un agonista del recettore sigma ed è stato ampiamente utilizzato nella ricerca scientifica negli studi di questo recettore. L'alazocina è descritta come un potente analgesico, psicotomimetico o allucinogeno e morfina o antagonista degli oppioidi . Inoltre, uno dei suoi enantiomeri è stato il primo composto che è stato trovato per etichettare selettivamente il recettore sigma σ 1 e ha portato alla scoperta e alla caratterizzazione del recettore. (it)
dbo:casNumber
  • 133005-41-1 ((+)-isomer)
  • 14198-28-8 ((–)-isomer)
  • 34061-23-9 (hydrochloride)
  • 58640-82-7 ((+)-isomer)
  • 74957-58-7 ((–)-isomer)
  • 825594-24-9
dbo:chEMBL
  • 274099
dbo:fdaUniiCode
  • L884482HDD
dbo:pubchem
  • 1235
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dbp:synonyms
  • SKF-10047; WIN-19631; N-Allylnormetazocine; NANM; NAN; ANMC; 2'-Hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan (en)
dbp:unii
  • L884482HDD (en)
dbp:verifiedfields
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rdfs:comment
  • Alazocine (developmental code name SKF-10047), also known more commonly as N-allylnormetazocine (NANM), is a synthetic opioid analgesic of the benzomorphan family related to metazocine, which was never marketed. In addition to its opioid activity, the drug is a sigma receptor agonist, and has been used widely in scientific research in studies of this receptor. Alazocine is described as a potent analgesic, psychotomimetic or hallucinogen, and opioid antagonist. Moreover, one of its enantiomers was the first compound that was found to selectively label the σ1 receptor, and led to the discovery and characterization of the receptor. (en)
  • アラゾシン（英: alazocine、開発コード: SKF-10047）は、と関連したベンゾモルファン系の合成オピオイド鎮痛剤であり、市販されたことはない。N-アリルノルメタゾシン（N-allylnormetazocine、NANM）の名称でも一般的に知られる。オピオイド活性に加えて、のアゴニストでもあり、この受容体の研究に広く利用されている。アラゾシンは強力な鎮痛剤、、幻覚剤、モルヒネ様物質、として記載されている。さらに、エナンチオマーの1つはを選択的に標識することが発見された最初の化合物であり、この受容体の発見と特徴づけを導いた。 (ja)
  • L'alazocina (noto nel corso del suo sviluppo con il nome di SKF -10047), noto anche più comunemente come N -allilnormetazocina ( NANM ), è un analgesico oppiaceo sintetico della famiglia benzomorpana correlato alla metazocina, che non è mai stato commercializzato. Oltre alla sua attività oppioide, il farmaco è un agonista del recettore sigma ed è stato ampiamente utilizzato nella ricerca scientifica negli studi di questo recettore. L'alazocina è descritta come un potente analgesico, psicotomimetico o allucinogeno e morfina o antagonista degli oppioidi . Inoltre, uno dei suoi enantiomeri è stato il primo composto che è stato trovato per etichettare selettivamente il recettore sigma σ 1 e ha portato alla scoperta e alla caratterizzazione del recettore. (it)
rdfs:label
  • Alazocine (en)
  • Alazocina (it)
  • アラゾシン (ja)
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