About: Alamandine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Alamandine is a member of renin-angiotensin system (RAS) with cardiovascular functions that are protective and opposing to the classical axis. Alamandine is a product of ACE2-dependent catalytic hydrolysis of angiotensin A (Ang A) and can also be generated by decarboxylation of aspartic acid residue of Ang-(1-7). Ang A is Ala1-Ang II (alanine in place of aspartic acid). In mononuclear leucocytes, angiotensin II (Ang II) is converted to Ang A by decarboxylation of aspartic acid. Ang A is detected in human circulation and was shown to be higher in individuals with end-stage renal disease.

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  • Alamandine is a member of renin-angiotensin system (RAS) with cardiovascular functions that are protective and opposing to the classical axis. Alamandine is a product of ACE2-dependent catalytic hydrolysis of angiotensin A (Ang A) and can also be generated by decarboxylation of aspartic acid residue of Ang-(1-7). Ang A is Ala1-Ang II (alanine in place of aspartic acid). In mononuclear leucocytes, angiotensin II (Ang II) is converted to Ang A by decarboxylation of aspartic acid. Ang A is detected in human circulation and was shown to be higher in individuals with end-stage renal disease. (en)
dbo:alternativeName
  • H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH; L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline (en)
dbo:iupacName
  • (2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid (en)
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  • 10172 (xsd:nonNegativeInteger)
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  • 1102592572 (xsd:integer)
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  • Alamandine.svg (en)
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  • 250 (xsd:integer)
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  • -1 (xsd:integer)
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  • H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH; L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline (en)
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  • Alamandine is a member of renin-angiotensin system (RAS) with cardiovascular functions that are protective and opposing to the classical axis. Alamandine is a product of ACE2-dependent catalytic hydrolysis of angiotensin A (Ang A) and can also be generated by decarboxylation of aspartic acid residue of Ang-(1-7). Ang A is Ala1-Ang II (alanine in place of aspartic acid). In mononuclear leucocytes, angiotensin II (Ang II) is converted to Ang A by decarboxylation of aspartic acid. Ang A is detected in human circulation and was shown to be higher in individuals with end-stage renal disease. (en)
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  • Alamandine (en)
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