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- The adaptive response is a form of direct DNA repair in E. coli that protects DNA from damage by external agents or by errors during replication. It is initiated against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA. Under sustained exposure to low-level treatment with alkylating mutagens, E. coli can adapt to the presence of the mutagen, rendering subsequent treatment with high doses of the same agent less effective. This mechanism has four related genes, also known as “SOS genes”: ada, alkA, alkB, and , each one working in specific residues, all regulated by ada protein. The adaptive response is mediated by the ada protein (a part of the ada regulon), which covalently transfers alkyl groups from the damaged DNA to one of its two active methyl acceptor cysteine residues: Cys69 and Cys321. Ada protein can repair the damage by transferring methyl groups from O6-methylguanine or O4-methylthymine to Cys321 and also from methylphosphotriesters to Cys69 residue through an irreversible process. It can also convert the protein from a weak to a strong activator of transcription, increasing alkylation repair activity. (en)
- Адаптивный ответ — одно из проявлений радиационного гормезиса. Характеристика стимулирующего эффекта малых доз радиации. (ru)
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- Адаптивный ответ — одно из проявлений радиационного гормезиса. Характеристика стимулирующего эффекта малых доз радиации. (ru)
- The adaptive response is a form of direct DNA repair in E. coli that protects DNA from damage by external agents or by errors during replication. It is initiated against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA. Under sustained exposure to low-level treatment with alkylating mutagens, E. coli can adapt to the presence of the mutagen, rendering subsequent treatment with high doses of the same agent less effective. (en)
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- Adaptive response (en)
- Адаптивный ответ (ru)
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