About: AL-37350A

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

AL-37350A (4,5-DHP-AMT) is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma.

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dbo:abstract
  • AL-37350A (4,5-DHP-AMT) is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma. (en)
dbo:casNumber
  • 362603-40-5
dbo:chEMBL
  • 133455
dbo:fdaUniiCode
  • KT54N4CC67
dbo:pubchem
  • 10331436
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  • 362603 (xsd:integer)
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  • 133455 (xsd:integer)
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  • 8506896 (xsd:integer)
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  • 18 (xsd:integer)
dbp:iupacName
  • --1--8,9-dihydropyrano[3,2-e]indole (en)
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  • 2 (xsd:integer)
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dbp:pubchem
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dbp:smiles
  • O2c1ccc3ccC[C@@H]C (en)
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  • VVHJUSGIUWQPIT-VIFPVBQESA-N (en)
dbp:unii
  • KT54N4CC67 (en)
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  • changed (en)
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  • changed (en)
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  • AL-37350A (4,5-DHP-AMT) is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma. (en)
rdfs:label
  • AL-37350A (en)
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