In enzymology, a 8-amino-7-oxononanoate synthase (EC 2.3.1.47) is an enzyme that catalyzes the chemical reaction 6-carboxyhexanoyl-CoA + L-alanine 8-amino-7-oxononanoate + CoA + CO2 Thus, the two substrates of this enzyme are and L-alanine, whereas its 3 products are , CoA, and CO2. This enzyme participates in biotin metabolism. It employs one cofactor, pyridoxal phosphate.