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- 5′-Phosphoribosylformylglycinamidine (or FGAM) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. The vitamins thiamine and cobalamin also contain fragments derived from FGAM. The compound is biosynthesized from phosphoribosyl-N-formylglycineamide (FGAR) which is converted to an amidine by the action of phosphoribosylformylglycinamidine synthase (EC 6.3.5.3), transferring an amino group from glutamine in a reaction that also requires ATP: FGAR + ATP + glutamine + H2O → FGAM + ADP + glutamate + Pi The biosynthesis pathway next converts FGAM to 5-aminoimidazole ribotide (AIR) by the action of AIR synthetase (EC 6.3.3.1) which uses ATP to activate the terminal carbonyl group to attack by the nitrogen atom at the anomeric center: FGAM + ATP → AIR + ADP + Pi + H+ (en)
- La 5'-phosphoribosylformylglycinamidine (FGAM) est un intermédiaire de la biosynthèse des purines et de l'inosine monophosphate (IMP). Elle est produite à partir de phosphoribosyl-N-formylglycinamide par la (en) (EC 6.3.5.3). (fr)
- 폼일글리신아미딘 리보뉴클레오타이드(영어: formylglycinamidine ribonucleotide, FGAM) 또는 5'포스포리보실폼일글리신아미딘(영어: 5'-phosphoribosylformylglycinamidine)은 퓨린 뉴클레오타이드 합성의 대사 중간생성물이다. 폼일글리신아미딘 리보뉴클레오타이드(FGAM)는 폼일글리신아미딘 리보뉴클레오타이드 아미도트랜스퍼레이스(FGAR 아미도트랜스퍼레이스)에 의해 폼일글리신아마이드 리보뉴클레오타이드(FGAR)로부터 생성된다. (ko)
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- [(2R,3S,4R,5R)-5-[(1-Amino-2-formamidoethylidene)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate (en)
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- 4587 (xsd:nonNegativeInteger)
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- phosphoribosylformylglycinamidine.svg (en)
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- [-5-[amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate (en)
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- La 5'-phosphoribosylformylglycinamidine (FGAM) est un intermédiaire de la biosynthèse des purines et de l'inosine monophosphate (IMP). Elle est produite à partir de phosphoribosyl-N-formylglycinamide par la (en) (EC 6.3.5.3). (fr)
- 폼일글리신아미딘 리보뉴클레오타이드(영어: formylglycinamidine ribonucleotide, FGAM) 또는 5'포스포리보실폼일글리신아미딘(영어: 5'-phosphoribosylformylglycinamidine)은 퓨린 뉴클레오타이드 합성의 대사 중간생성물이다. 폼일글리신아미딘 리보뉴클레오타이드(FGAM)는 폼일글리신아미딘 리보뉴클레오타이드 아미도트랜스퍼레이스(FGAR 아미도트랜스퍼레이스)에 의해 폼일글리신아마이드 리보뉴클레오타이드(FGAR)로부터 생성된다. (ko)
- 5′-Phosphoribosylformylglycinamidine (or FGAM) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. The vitamins thiamine and cobalamin also contain fragments derived from FGAM. The compound is biosynthesized from phosphoribosyl-N-formylglycineamide (FGAR) which is converted to an amidine by the action of phosphoribosylformylglycinamidine synthase (EC 6.3.5.3), transferring an amino group from glutamine in a reaction that also requires ATP: FGAR + ATP + glutamine + H2O → FGAM + ADP + glutamate + Pi (en)
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- 5′-Phosphoribosylformylglycinamidine (en)
- Phosphoribosylformylglycinamidine (fr)
- 폼일글리신아미딘 리보뉴클레오타이드 (ko)
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