In enzymology, a 4-chlorobenzoyl-CoA dehalogenase (EC 3.8.1.7) is an enzyme that catalyzes the chemical reaction 4-chlorobenzoyl-CoA + H2O 4-hydroxybenzoyl CoA + chloride Thus, the two substrates of this enzyme are and H2O, whereas its two products are and chloride. This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoyl CoA chlorohydrolase. This enzyme participates in .