The 2021–22 Coupe de France preliminary rounds, Occitanie was the qualifying competition to decide which teams from the leagues of the Occitanie region of France took part in the main competition from the seventh round. A total of ten teams qualified from the Occitanie preliminary rounds. In 2020–21, Canet Roussillon FC progressed furthest in the competition, reaching the quarter-finals, beating Marseille along the way, before losing to Montpellier.