The 2012 DRIVE4COPD 300 was a NASCAR Nationwide Series race held on February 25, 2012 at Daytona International Speedway in Daytona Beach, Florida. It was the first race of the 2012 NASCAR Nationwide Series season. The race was the 31st running of the event. Danica Patrick won the pole but in the race's end, a surprise winner happened with James Buescher winning his first and only Nationwide Series race of his entire career in an last lap wreck that took out most of the top 10 cars.