The 2006 United States Senate election in Missouri was held November 7, 2006, to decide who would serve as senator for Missouri between January 3, 2007, and January 3, 2013. The incumbent was Republican Jim Talent. Talent was elected in a special election in 2002 when he narrowly defeated incumbent Democrat Jean Carnahan. Carnahan had been appointed to the Senate seat following the posthumous election of her husband Mel Carnahan, who had died in a plane crash shortly before the 2000 election. Talent's Democratic opponent was Missouri State Auditor Claire McCaskill. Early on the morning of November 8, Talent conceded defeat to McCaskill, having faced considerable political headwinds. Talent lost the election with 47% of the vote, to 50% of the vote for McCaskill. This was the last election
