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- In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) is an enzyme that catalyzes the chemical reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
* 2-C-methylerythritol 4-phosphate
* Cytidine triphosphate
* 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) Thus, the two substrates of this enzyme are CTP and 2-C-methyl-D-erythritol 4-phosphate, whereas its two products are diphosphate and 4-diphosphocytidyl-2-C-methylerythritol. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in isoprenoid biosynthesis and stenvenosim. It catalyzes the third step of the MEP pathway; the formation of CDP-ME (4-diphosphocytidyl-2C-methyl-D-erythritol) from CTP and MEP (2C-methyl-D-erythritol 4-phosphate). The isoprenoid pathway is a well known target for anti-infective drug development. (en)
- La 2-C-méthyl-D-érythritol-4-phosphate cytidylyltransférase, ou 4-diphosphocytidyl-2-C-méthyl-D-érythritol synthase, est une nucléotidyltransférase qui catalyse la conversion du 2-C-méthylérythritol-4-phosphate (MEP) en 4-diphosphocytidyl-2-C-méthylérythritol (CDP-ME) : L'ion manganèse Mn2+ ou magnésium Mg2+ intervient comme cofacteur dans cette réaction. Cette enzyme intervient à la troisième étape de la voie du méthylérythritol phosphate, qui est une voie métabolique de biosynthèse de l'isopentényl-pyrophosphate (IPP) et du diméthylallyl-pyrophosphate (DMAPP) alternative à la voie du mévalonate chez les plantes, certains protozoaires et la plupart des bactéries, l'IPP et le DMAPP étant des métabolites qui conduisent notamment à la synthèse des terpénoïdes.
* Portail de la biochimie (fr)
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- In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) is an enzyme that catalyzes the chemical reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
* 2-C-methylerythritol 4-phosphate
* Cytidine triphosphate
* 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) Thus, the two substrates of this enzyme are CTP and 2-C-methyl-D-erythritol 4-phosphate, whereas its two products are diphosphate and 4-diphosphocytidyl-2-C-methylerythritol. (en)
- La 2-C-méthyl-D-érythritol-4-phosphate cytidylyltransférase, ou 4-diphosphocytidyl-2-C-méthyl-D-érythritol synthase, est une nucléotidyltransférase qui catalyse la conversion du 2-C-méthylérythritol-4-phosphate (MEP) en 4-diphosphocytidyl-2-C-méthylérythritol (CDP-ME) : L'ion manganèse Mn2+ ou magnésium Mg2+ intervient comme cofacteur dans cette réaction.
* Portail de la biochimie (fr)
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- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (en)
- 2-C-méthyl-D-érythritol-4-phosphate cytidylyltransférase (fr)
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- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (en)
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