The 1958 Detroit Titans football team represented the University of Detroit as an independent during the 1958 NCAA University Division football season. In their fifth and final year under head coach Wally Fromhart, the Titans compiled a 4–4–1 record and were outscored by a combined total of 157 to 131. The team's statistical leaders included Lou Faoro with 584 passing yards and Bruce Maher with 576 rushing yards, 295 receiving yards, and 42 points scored.