The 1949 Detroit Titans football team represented the University of Detroit in the Missouri Valley Conference (MVC) during the 1949 college football season. In their fifth year under head coach Chuck Baer, the Titans compiled a 5–4 record (4–0 against conference opponents), won the MVC championship, and outscored all opponents by a combined total of 179 to 165. The 1949 season was Detroit's first in the MVC.