The 1941 Duke Blue Devils football team was an American football team that represented Duke University as a member of the Southern Conference during the 1941 college football season. In their 11th season under head coach Wallace Wade, the Blue Devils compiled a 9–0 record during the regular season, won the Southern Conference championship, and outscored opponents by a total of 311 to 41. Ranked No. 2 in the final AP Poll, the Blue Devils were invited to play in the 1942 Rose Bowl (played at Duke Stadium), losing to Oregon State by a 20–16 score.