Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009. Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process and its safety and efficacy data are limited.

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dbo:abstract
  • Le chlophédianol est une molécule chimique indiquée dans le traitement de la toux. Des doses de 25 mg aux 6 à 8 heures sont recommandées pour avoir un effet appréciable et juste de l'élévation du réflexe de la toux au niveau du système nerveux central. Pour les enfants, une dose de 12,5 à 25 mg est indiquée. (fr)
  • Clofedanol é um fármaco antitussígeno. Obteve status de medicamento OTC em 1987 pelo FDA. Foi introduzido em 1960, como resultado em pesquisas para a obtenção de medicamentos antiespasmódicos. (pt)
  • Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009. Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process and its safety and efficacy data are limited. (en)
dbo:atcPrefix
  • R05
dbo:atcSuffix
  • DB10
dbo:casNumber
  • 791-35-5
dbo:drugbank
  • DB04837
dbo:fdaUniiCode
  • 42C50P12AP
dbo:iupacName
  • 1-(2-chlorophenyl)-3-dimethylamino- (en)
  • 1-phenyl-propan-1-ol (en)
dbo:pubchem
  • 2795
dbo:thumbnail
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  • 10686280 (xsd:integer)
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  • 714463119 (xsd:integer)
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  • 17 (xsd:integer)
dbp:chembl
  • 1201313 (xsd:integer)
dbp:chemspiderid
  • 2693 (xsd:integer)
dbp:cl
  • 1 (xsd:integer)
dbp:date
  • November 2011
dbp:h
  • 20 (xsd:integer)
dbp:inaccurate
  • yes
dbp:iupharLigand
  • 7324 (xsd:integer)
dbp:kegg
  • D07721
dbp:molecularWeight
  • 289.800000 (xsd:double)
dbp:n
  • 1 (xsd:integer)
dbp:o
  • 1 (xsd:integer)
dbp:routesOfAdministration
  • Oral
dbp:smiles
  • Clc1ccccc1CCCNC
dbp:stdinchi
  • 1 (xsd:integer)
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  • WRCHFMBCVFFYEQ-UHFFFAOYSA-N
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  • changed
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  • 460043162 (xsd:integer)
dct:subject
rdf:type
rdfs:comment
  • Le chlophédianol est une molécule chimique indiquée dans le traitement de la toux. Des doses de 25 mg aux 6 à 8 heures sont recommandées pour avoir un effet appréciable et juste de l'élévation du réflexe de la toux au niveau du système nerveux central. Pour les enfants, une dose de 12,5 à 25 mg est indiquée. (fr)
  • Clofedanol é um fármaco antitussígeno. Obteve status de medicamento OTC em 1987 pelo FDA. Foi introduzido em 1960, como resultado em pesquisas para a obtenção de medicamentos antiespasmódicos. (pt)
  • Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009. Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process and its safety and efficacy data are limited. (en)
rdfs:label
  • Chlophédianol (fr)
  • Clofedanol (en)
  • Clofedanol (pt)
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