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About: Epiboxidine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatNitrogenHeterocyclesyago:WikicatStimulantsyago:Abstraction100002137yago:Chemical114806838yago:Cognition100023271yago:Compound114818238yago:HeterocyclicCompound115025397yago:Information105816287yago:Material114580897yago:Matter100020827yago:Part113809207yago:PhysicalEntity100001930yago:PsychologicalFeature100023100yago:Relation100031921chemical compounddrugyago:Stimulation105827684yago:Substance100019613umbel-rc:DrugProduct New Facet based on Instances of this Class

Epiboxidine is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It was developed as a less toxic analogue of the potent frog-derived alkaloid epibatidine, which is around 200 times stronger than morphine as an analgesic but produces extremely dangerous toxic nicotinic side effects. Epiboxidine is around one-tenth as potent as epibatidine as an α4β2 agonist, but has around the same potency as an α3β4 agonist. It has only one-tenth of the analgesic power of epibatidine, but is also much less toxic.