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Nicotinic acetylcholine receptors, or nAChRs, are neuron receptor proteins that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs, including the nicotinic receptor agonist nicotine. They are found in the central nervous system of humans, and also play two important roles in the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. Nicotinic receptors are also found in other creatures. In insects, the cholinergic system is limited to the central nervous system.

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  • Nicotinic acetylcholine receptor
  • Nikotinischer Acetylcholinrezeptor
  • Receptor nicotínico
  • Récepteur nicotinique
  • Recettore nicotinico
  • Receptory nikotynowe
  • Receptor nicotínico
  • Никотиновый ацетилхолиновый рецептор
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  • Los receptores nicotínicos son canales iónicos colinérgicos, es decir, que son capaces de responder al mediador químico acetilcolina; se denominan nicotínicos porque pueden ser activados por la nicotina, a diferencia de los receptores muscarínicos, que son activados por la muscarina (Rawn, 1989).
  • Le récepteur nicotinique de l’acétylcholine est un récepteur ionotrope perméable aux ions sodium ainsi qu'aux ions K+ (canal cationique non spécifique), sensible à l'acétylcholine. Il tient son nom de l'un de ses agonistes, la nicotine, par opposition aux récepteurs muscariniques (récepteurs métabotropes). Il fait partie de la super-famille des récépteurs-canaux nicotinoïdes.
  • Никотиновый ацетилхолиновый рецептор (н-холинорецептор, nACh-receptor) — подвид ацетилхолиновых рецепторов, который обеспечивает передачу нервного импульса через синапсы и активируется ацетилхолином, а также никотином. Этот рецептор вместе с ГАМКA-, ГАМКC- глициновым и 5-HT3-рецепторами образует семейство лиганд-зависимых ионных каналов с цистеиновой петлёй.
  • Nicotinic acetylcholine receptors, or nAChRs, are neuron receptor proteins that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs, including the nicotinic receptor agonist nicotine. They are found in the central nervous system of humans, and also play two important roles in the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. Nicotinic receptors are also found in other creatures. In insects, the cholinergic system is limited to the central nervous system.
  • Nikotinische Acetylcholinrezeptoren (nAChR), auch kurz Nikotinrezeptoren, sind membranständige Rezeptoren in verschiedenen Nervenzellen und in Muskelfasern, die als Substrat den Neurotransmitter Acetylcholin (ACh) binden, doch auch durch Nikotin und ähnliche nikotinerge Substanzen aktiviert werden können. Diese ionotropen Rezeptoren bestehen aus fünf Untereinheiten, die neben den rezeptiven Bindungsstellen gemeinsam eine die Zellmembran durchspannende Pore bilden und somit einen ligandengesteuerten Ionenkanal darstellen. Die muskarinischen Acetylcholinrezeptoren sind dagegen metabotrope membranständige Rezeptoren.
  • I recettori nicotinici (abbreviati in nAChR a causa del nome inglese Nicotinic acetylcholine receptors) sono recettori colinergici che formano canali ionici attivati da ligando nella membrana plasmatica di alcuni neuroni e nella porzione postsinaptica della giunzione neuromuscolare. In quanto recettori ionotropi, gli nAChR sono direttamente collegati al canale ionico e non fanno uso di secondi messaggeri (diversamente dai recettori metabotropici come i colingergici muscarinici). I recettori nicotinici rappresentano il modello più studiato di recettore ionotropico. Esistono diverse isoforme strutturali del recettore nicotinico, per questo, quando non ci si riferisce ad alcuna isoforma specifica, si preferisce parlare genericamente di recettori nicotinici.
  • Receptory nikotynowe N – białka receptorowe mające strukturę pentameru, zbudowanego z różnych kombinacji genetycznie odmiennych jednostek α (1-10), β (1-4), γ, δ i ε. Wykryto bardzo dużą liczbę neuronalnych podtypów receptora nikotynowego, jednak największą aktywność w ośrodkowym układzie nerwowym ssaków wykazują receptory N-α4β2, N-α3β4 oraz N-α7. Cytyzyna oraz podobna do niej pod względem strukturalnym wareniklina są silnymi agonistami receptora N-α4β2. Dekstrometorfan z kolei jest antagonistą receptora N-α3β4.
  • Os receptores nicotínicos são canais iónicos na membrana plasmática de algumas células, cuja abertura é disparada pelo neurotransmissor acetilcolina, fazendo parte do sistema colinérgico. O seu nome deriva do primeiro agonista selectivo encontrado para estes receptores, a nicotina, extraída da planta Nicotiana tabacum. O primeiro antagonista selectivo descrito é o curare (d-tubocurarina).
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