Zwelini Lawrence Mkhize (born 2 February 1956) is a South African medical doctor and politician who served as the Minister of Health from May 2019 until his resignation on 5 August 2021. He previously served as the Minister of Cooperative Governance and Traditional Affairs from 2018 to 2019. Before that, he was the fifth Premier of KwaZulu-Natal from 2009 to 2013.