JK-05 is a broad-spectrum antiviral drug developed by the Chinese company Sihuan Pharmaceutical along with the Chinese Academy of Military Medical Sciences. It is reported to act as an inhibitor of the viral enzyme RNA polymerase which is essential for viral replication. In tests on mice, JK-05 was claimed to show efficacy against a range of RNA viruses, including influenza, Ebola virus and yellow fever, as well as several arenaviruses and bunyaviruses. The chemical structure of JK-05 has not been disclosed as of October 2014, but it is claimed to be a small molecule drug with a comparatively simple structure, which should be readily amenable to synthesis scale-up for mass production if testing is successful. The drug is however admitted to be similar to the Japanese anti-influenza drug fa
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- JK-05 (de)
- JK-05 (fr)
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| - JK-05 ist ein experimentelles Virostatikum, das gegen verschiedene RNA-Viren wirkt. (de)
- JK-05 is a broad-spectrum antiviral drug developed by the Chinese company Sihuan Pharmaceutical along with the Chinese Academy of Military Medical Sciences. It is reported to act as an inhibitor of the viral enzyme RNA polymerase which is essential for viral replication. In tests on mice, JK-05 was claimed to show efficacy against a range of RNA viruses, including influenza, Ebola virus and yellow fever, as well as several arenaviruses and bunyaviruses. The chemical structure of JK-05 has not been disclosed as of October 2014, but it is claimed to be a small molecule drug with a comparatively simple structure, which should be readily amenable to synthesis scale-up for mass production if testing is successful. The drug is however admitted to be similar to the Japanese anti-influenza drug fa (en)
- Le JK-05 est un médicament antiviral expérimental à spectre large développé par une entreprise chinoise, Sihuan Pharmaceutical, en collaboration avec l'institut d'épidémiologie et de microbiologie de l'académie militaire des sciences médicales chinoise. Destiné dans un premier temps à répondre uniquement aux situations d'urgence d'ordre militaire, sa structure chimique étaient encore tenue secrète en janvier 2015. Le JK-05 serait une petite molécule agissant comme inhibiteur de l'ARN polymérase du virus Ebola et du virus de la grippe indispensable à la réplication de ces virus. Assez simple, cette molécule pourrait être produite rapidement en grande quantité si les essais cliniques s'avéraient concluants. Elle serait semblable au favipiravir, un autre antiviral développé cette fois par une (fr)
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| - JK-05 ist ein experimentelles Virostatikum, das gegen verschiedene RNA-Viren wirkt. (de)
- JK-05 is a broad-spectrum antiviral drug developed by the Chinese company Sihuan Pharmaceutical along with the Chinese Academy of Military Medical Sciences. It is reported to act as an inhibitor of the viral enzyme RNA polymerase which is essential for viral replication. In tests on mice, JK-05 was claimed to show efficacy against a range of RNA viruses, including influenza, Ebola virus and yellow fever, as well as several arenaviruses and bunyaviruses. The chemical structure of JK-05 has not been disclosed as of October 2014, but it is claimed to be a small molecule drug with a comparatively simple structure, which should be readily amenable to synthesis scale-up for mass production if testing is successful. The drug is however admitted to be similar to the Japanese anti-influenza drug favipiravir, developed by Fujifilm Holdings Corp, which has been used effectively to treat patients with Ebola. In addition, WHO committee members mentioned that the drug is a copy product of favipiravir, because patents of favipiravir were already registered in 2006 in China. The drug has been given preliminary approval by the Chinese authorities to be available for Chinese health workers involved in combating the 2014 West African Ebola outbreak, or if Ebola were to spread into mainland China. Several other Chinese developed antiviral drugs with anti-Ebola activity have also been disclosed, but have not progressed so far through development as JK-05. (en)
- Le JK-05 est un médicament antiviral expérimental à spectre large développé par une entreprise chinoise, Sihuan Pharmaceutical, en collaboration avec l'institut d'épidémiologie et de microbiologie de l'académie militaire des sciences médicales chinoise. Destiné dans un premier temps à répondre uniquement aux situations d'urgence d'ordre militaire, sa structure chimique étaient encore tenue secrète en janvier 2015. Le JK-05 serait une petite molécule agissant comme inhibiteur de l'ARN polymérase du virus Ebola et du virus de la grippe indispensable à la réplication de ces virus. Assez simple, cette molécule pourrait être produite rapidement en grande quantité si les essais cliniques s'avéraient concluants. Elle serait semblable au favipiravir, un autre antiviral développé cette fois par une filiale de la firme japonaise Fujifilm et qui s'est montré efficace pour traiter des patients souffrant de la maladie à virus Ebola. Des tests réalisés sur des souris auraient montré l'efficacité de cette molécule contre un ensemble de virus à ARN, dont le virus de la grippe, le virus Ebola et le virus de la fièvre jaune, ainsi que contre plusieurs arénavirus et bunyavirus.[réf. nécessaire] Le médicament a reçu un accord préliminaire des autorités chinoises pour qu'il soit disponible pour les soignants chinois impliqués dans le combat contre l'épidémie de 2014, ou si Ebola venait à gagner la Chine. (fr)
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