The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct interaction of G protein subunits with GIRK channels. The activation likely works by
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| - G protein-coupled inwardly-rectifying potassium channel (en)
- Courant potassique rectifiant activé par les protéines G (fr)
- GIRK (ru)
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| rdfs:comment
| - Le courant potassique rectifiant activé par les protéines G ou GIRK, pour l'anglais G-protein activated Inwardly Rectifying K+ current, appartient à la famille des courants potassiques rectifiant. Le terme rectifiant est ici utilisé en référence au composant électronique, le redresseur ((en) rectifier), qui n'est conducteur que pour une polarité. La séparation du complexe trimèrique des protéines G active ce courant via les sous-unités β (bêta) et γ (gamma). Ce courant entraîne une hyperpolarisation du potentiel de repos qui inhibe le neurone. (fr)
- G-белок-связанные калиевые каналы внутреннего выпрямления (так называемые GIRK) — это подсемейство калиевых каналов внутреннего выпрямления, которые активируются (открываются) вследствие передачи сигнала с активированного вследствие связывания лиганда-агониста G-белок-связанного рецептора, вследствие чего от G-белка отсоединяется димер из βγ-субъединиц, который и активирует GIRK. Каналы подтипа GIRK1, GIRK2 и GIRK3 широко представлены в ЦНС, где их области распределения частично перекрываются. Каналы подтипа GIRK4, однако, в основном находятся в сердце. (ru)
- The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct interaction of G protein subunits with GIRK channels. The activation likely works by (en)
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| foaf:name
| - potassium inwardly-rectifying channel, subfamily J, member 9 (en)
- potassium inwardly-rectifying channel, subfamily J, member 6 (en)
- potassium inwardly-rectifying channel, subfamily J, member 3 (en)
- potassium inwardly-rectifying channel, subfamily J, member 5 (en)
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| - KCNJ7, Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2 (en)
- Kir3.1, GIRK1, KGA (en)
- Kir3.3, GIRK3 (en)
- Kir3.4, CIR, KATP1, GIRK4 (en)
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| symbol
| - KCNJ3 (en)
- KCNJ5 (en)
- KCNJ6 (en)
- KCNJ9 (en)
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| UniProt
| - P48051 (en)
- P48544 (en)
- P48549 (en)
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