About: Adenosine diphosphate ribose

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Adenosine diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD+) as a cofactor. ADPR binds to and activates the TRPM2 ion channel. ADPR is the most potent agonist of the TRPM2 channel. cADPR also binds to TPRM2, and the action of both molecules is synergistic, with both molecules enhancing the action of the other molecule in activating the TRPM2 channel.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Chemical compound yago:WikicatMolecularFormulas yago:WikicatNucleotides yago:WikicatOrganophosphates yago:Abstraction100002137 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Ester114850483 yago:Formula106816935 yago:Insecticide114919948 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:Nucleotide114964590 yago:OrganicCompound114727670 yago:Organophosphate114969994 yago:Part113809207 yago:Pesticide114980215 yago:PhysicalEntity100001930 yago:Relation100031921 chemical compound yago:Statement106722453 yago:Substance100019613 umbel-rc:ChemicalSubstanceType
rdfs:label	Adenosine diphosphate ribose (en) Adénosine diphosphate ribose (fr) Adenosina difosfato ribosio (it) ADPリボース (ja) 아데노신 이인산 리보스 (ko) Аденозиндифосфатрибоза (ru) 二磷酸腺苷核糖 (zh)
rdfs:comment	Adenosine diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD+) as a cofactor. ADPR binds to and activates the TRPM2 ion channel. ADPR is the most potent agonist of the TRPM2 channel. cADPR also binds to TPRM2, and the action of both molecules is synergistic, with both molecules enhancing the action of the other molecule in activating the TRPM2 channel. (en) ADPリボース(Adenosine diphosphate ribose)は、によって形成される分子である。イオンチャネルに結合し、活性化させる。 (ja) 아데노신 이인산 리보스(영어: allose, ADPR) 또는 ADP-리보스(영어: ADP-ribose)는 에 의해 형성되는 에스터 분자이다. 아데노신 이인산 리보스는 이온 통로에 결합하고, TRPM2 이온 통로를 활성화시킨다. (ko) L'adenosina difosfato ribosio o ADP-ribosio (ADPR) è un composto biochimico sintetizzato in forma di catene per la poli ADP-ribosio polimerasi. Può essere descritto come una molecola di ADP esterificato con un ribosio terminale. Si attiva, legandosi a canali ionici TRPM2,il cui ruolo è ancora poco conosciuto, ma dovrebbe intervenire nella secrezione di insulina, nella modulazione di una parte della risposta al fattore di necrosi tumorale nei leucociti,e nella tossicità di beta amiloide nel cervello, una proteina associata alla malattia di Alzheimer. (it) Аденозиндифосфатрибоза (АДФ-рибоза) — сложный эфир, участвующий в посттрасляционной модификации белков. Присоединение остатка АДФ-рибозы к белкам называется АДФ-рибозилированием, донором АДФ-рибозы в этих процессах служит NAD+. Поли-АДФ-рибоза выступает в роли сигнальной молекулы для белков репарации ДНК и используется для модификации гистонов. Аденозиндифосфатрибоза активирует ионный канал . (ru) 二磷酸腺苷核糖（英語：Adenosine diphosphate ribose，或ADP-ribose，ADP-核糖）是一个由ADP的另一个磷酸基团再与核糖结合而形成的分子，可结合并激活离子通道。 (zh) L’adénosine diphosphate ribose (ADP-ribose, ADPR), est un composé biochimique synthétisé sous forme de chaînes par la poly(ADP-ribose) polymérase. Elle peut être décrite comme une molécule d'adénosine diphosphate estérifiée par un ribose terminal. Elle active, en s'y liant, le canal ionique TRPM2, au rôle encore mal compris mais qui interviendrait dans la sécrétion de l'insuline, dans la modulation d'une partie de la réponse au facteur de nécrose tumorale dans les leucocytes, ainsi que dans la toxicité, dans le cerveau, de la bêta-amyloïde, une protéine associée à la maladie d'Alzheimer. (fr)
foaf:depiction
dcterms:subject	Organophosphates Phosphate esters Nucleotides NADH dehydrogenase inhibitors
Wikipage page ID	10742226 (xsd:integer)
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Link from a Wikipage to another Wikipage	Ribose Organophosphates Phosphate esters Ester Poly ADP ribose polymerase Synergy Adenosine diphosphate Agonist Nucleotides Cyclic ADP-ribose Nicotinamide adenine dinucleotide ADP-ribosylation NADH dehydrogenase inhibitors Cofactor (biochemistry) CD38 TRPM2
sameAs	Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose Adenosine diphosphate ribose
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ImageFile	ADP ribose.svg (en) ADP-ribose 3D.png (en) Three-dimensional model of ADP ribose.png (en)
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