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Statements

Subject Item
dbr:Richter's_transformation
rdf:type
dbo:Disease yago:WikicatHematologicNeoplasms yago:Abstraction100002137 yago:PathologicalState114051917 yago:Tumor114235200 yago:State100024720 yago:Growth114234074 yago:Attribute100024264 yago:Illness114061805 yago:IllHealth114052046 dbo:ProgrammingLanguage yago:Condition113920835 owl:Thing yago:PhysicalCondition114034177 wikidata:Q12136
rdfs:label
Síndrome de Richter Sindrome di Richter Syndrome de Richter متلازمة ريختر Richter's transformation
rdfs:comment
متلازمة ريختر هي منحى خطير يسلكه سرطان ابيضاض الدم الليمفاوي المزمن حيث يتحول إلى سرطان الغدد الليمفاوية الكبيرة المنتشر. Le syndrome de Richter est la survenue d'un lymphome de haut grade au cours d'une leucémie lymphoïde chronique. Il s'observe dans 3 à 10 % des cas.L'apparition d'un syndrome de Richter classe immédiatement la LLC en stade C de la . Il a été décrit en 1928 par le pathologiste américain M.N. Richter. Síndrome de Richter é uma rara complicação da leucemia linfóide crônica (LLC) ou da tricoleucemia (HCL). Na síndrome de Richter, a LLC transforma-se em uma forma agressiva onde as células B crescem rapidamente.[1]. Ela acomete cerca de 2% a 8% dos pacientes com LLC. Per sindrome di Richter in campo medico si intende un linfoma a grandi cellule, costituisce una complicanza che nasce in persone affette da leucemia linfatica cronica, che viene evidenziata per la comparsa improvvisa dei sintomi. Il linfoma è spesso di tipo B, raramente di tipo T. Richter's transformation (RT), also known as Richter's syndrome, is the conversion of chronic lymphocytic leukemia (CLL) or its variant, small lymphocytic lymphoma (SLL), into a new and more aggressively malignant disease. CLL is the circulation of malignant B lymphocytes with or without the infiltration of these cells into lymphatic or other tissues while SLL is the infiltration of these malignant B lymphocytes into lymphatic and/or other tissues with little or no circulation of these cells in the blood. CLL along with its SLL variant are grouped together in the term CLL/SLL.
foaf:name
Richter's transformation
dbp:name
Richter's transformation
foaf:depiction
n16:Reed-Sternberg_lymphocyte_nci-vol-7172-300.jpg
dcterms:subject
dbc:Rare_cancers dbc:Leukemia
dbo:wikiPageID
12120994
dbo:wikiPageRevisionID
1121801563
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n7:55Tpy dbpedia-ar:متلازمة_ريختر dbpedia-fr:Syndrome_de_Richter n12:Richterio_sindromas freebase:m.02vqgvr dbpedia-pt:Síndrome_de_Richter wikidata:Q938329 yago-res:Richter's_transformation dbpedia-it:Sindrome_di_Richter
dbp:types
Diffuse large B-cell lymphoma type, Hodgkin's lymphoma type
dbp:wikiPageUsesTemplate
dbt:Infobox_medical_condition_(new) dbt:Reflist
dbo:thumbnail
n16:Reed-Sternberg_lymphocyte_nci-vol-7172-300.jpg?width=300
dbp:field
dbr:Hematopathology dbr:Surgical_oncology dbr:Oncology
dbp:frequency
rare
dbp:synonyms
Richter's syndrome
dbo:abstract
Richter's transformation (RT), also known as Richter's syndrome, is the conversion of chronic lymphocytic leukemia (CLL) or its variant, small lymphocytic lymphoma (SLL), into a new and more aggressively malignant disease. CLL is the circulation of malignant B lymphocytes with or without the infiltration of these cells into lymphatic or other tissues while SLL is the infiltration of these malignant B lymphocytes into lymphatic and/or other tissues with little or no circulation of these cells in the blood. CLL along with its SLL variant are grouped together in the term CLL/SLL. RT is diagnosed in individuals who have CLL/SLL that converts to a malignancy with the microscopic histopathology of diffuse large B-cell lymphoma (DLBCL) or, less commonly, Hodgkin’s lymphoma (HL). There are rare cases of: 1) CLL/SLLs that convert into lymphoblastic lymphoma, hairy cell leukemia, or a high grade T cell lymphoma such as anaplastic large-cell lymphoma or angioimmunoblastic T-cell lymphoma; 2) CLL/SLLs that convert into acute myeloid leukemia; 3) CLL/SLLs that convert into or develop non-hematological malignancies such as lung cancer, brain cancer, melanoma of the eye or skin, salivary gland tumors, and Kaposi's sarcomas; and 4) conversion of follicular lymphoma, lymphoblastic lymphoma, or marginal zone lymphoma into other types of hematological malignancies. While some of these conversions have been termed RTs, the World Health Organization and most reviews have defined RT as a conversion of CLL/SLL into a disease with DLBCL or HL histopathology. Here, RTs are considered to be CLL/SLLs which convert into a disease with either DLBCL histopathology (here termed DLBCL-RT) or Hodgkin's lymphoma histopathology (here termed HL-RT). CLL/SLL is the most common adult leukemia in Western countries, accounting for 1.2% of the new cancers diagnosed each year in the United States. It usually occurs in older adults (median age at diagnosis 70) and follows an indolent course over many years. About 1-10% of CLL/SLLs develop a Richter's transformation at a rate of 0.5–1% per year. In earlier studies, the transformed disease was reported to be far more aggressive than CLL/SLL with overall median survival times (i.e. times in which 50% of cases remain alive) between 1.1 and 16.3 months. Newer therapeutic regimens are improving the prognosis of DLBCL-RT and HL-RT. Le syndrome de Richter est la survenue d'un lymphome de haut grade au cours d'une leucémie lymphoïde chronique. Il s'observe dans 3 à 10 % des cas.L'apparition d'un syndrome de Richter classe immédiatement la LLC en stade C de la . Il a été décrit en 1928 par le pathologiste américain M.N. Richter. متلازمة ريختر هي منحى خطير يسلكه سرطان ابيضاض الدم الليمفاوي المزمن حيث يتحول إلى سرطان الغدد الليمفاوية الكبيرة المنتشر. Síndrome de Richter é uma rara complicação da leucemia linfóide crônica (LLC) ou da tricoleucemia (HCL). Na síndrome de Richter, a LLC transforma-se em uma forma agressiva onde as células B crescem rapidamente.[1]. Ela acomete cerca de 2% a 8% dos pacientes com LLC. Per sindrome di Richter in campo medico si intende un linfoma a grandi cellule, costituisce una complicanza che nasce in persone affette da leucemia linfatica cronica, che viene evidenziata per la comparsa improvvisa dei sintomi. Il linfoma è spesso di tipo B, raramente di tipo T.
dbp:prognosis
Poor
gold:hypernym
dbr:Transformation
prov:wasDerivedFrom
wikipedia-en:Richter's_transformation?oldid=1121801563&ns=0
dbo:wikiPageLength
37431
foaf:isPrimaryTopicOf
wikipedia-en:Richter's_transformation