. . "O=CNCC"@en . "changed"@en . "D08423"@en . "Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers. For Hodgkin's it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. It is typically taken by mouth. Common side effect include low blood cell counts and vomiting. Other side effects include tiredness and depression. It is not recommended in people with severe liver or kidney problems. Use in pregnancy is known to harm the baby. Procarbazine is in the alkylating agents family of medication. How it works is not clearly known. Procarbazine was approved for medical use in the United States in 1969. It is on the World Health Organization's List of Essential Medicines. In the United Kingdom a month of treatment cost the National Health Service 450 to 750 pounds."@en . . "D"@en . . . . 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"3"^^ . "a682094"@en . . . . . . . . "Procarbazina"@es . "\u041F\u0440\u043E\u043A\u0430\u0440\u0431\u0430\u0437\u0438\u043D \u2014 \u043F\u0440\u043E\u0442\u0438\u0432\u043E\u043E\u043F\u0443\u0445\u043E\u043B\u0435\u0432\u044B\u0439 \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442, \u0430\u043B\u043A\u0438\u043B\u0438\u0440\u0443\u044E\u0449\u0435\u0435 \u0441\u043E\u0435\u0434\u0438\u043D\u0435\u043D\u0438\u0435 \u0438\u0437 \u0433\u0440\u0443\u043F\u043F\u044B \u043C\u0435\u0442\u0438\u043B\u0433\u0438\u0434\u0440\u0430\u0437\u0438\u043D\u043E\u0432."@ru . . "kidney"@en . "Procarbazine"@fr . "1"^^ . "D08423" . "XB01"@en . . "Procarbazine ball-and-stick.png"@en . "7278"^^ . . . . . . "Procarbazina"@it . "La procarbazina \u00E8 un farmaco chemioterapico di tipo alchilante, usato principalmente nel linfoma di Hodgkin e certi tipi di tumori cerebrali come il glioblastoma multiforme. Agisce formando un legame covalente con il DNA impedendo cos\u00EC la duplicazione e crescita delle cellule cancerose e non. Viene metabolizzato ed attivato nel fegato ed \u00E8 noto avere la capacit\u00E0 di inibire la monoamino-ossidasi IMAO, aumentando cos\u00EC gli effetti dei farmaci simpaticomimetici, degli antidepressivi triciclici e della tiramina.La procarbazina pu\u00F2 anche causare una reazione disulfiram-simile con l'assunzione concomitante di alcool. Con l'uso di procarbazina, pu\u00F2 aumentare il rischio di insorgenza di alcune leucemie, specie quando associato a vincristina e prednisone \u00C8 commercializzato con i nomi di: Matulane (USA), Natulan (Canada e Italia), Indicarb (India)."@it . "CPTBDICYNRMXFX-UHFFFAOYSA-N"@en . . "Procarbazine"@en . 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"671-16-9" . . "Prokarbazyna"@pl . . "1"^^ . "2210572"^^ . . . . "Prokarbazyna (PCB) \u2013 organiczny zwi\u0105zek chemiczny, lek przeciwnowotworowy, inhibitor replikacji DNA. Blokuje wytwarzanie bia\u0142ek i DNA przez kom\u00F3rki nowotworu poprzez degradacj\u0119 matrycy DNA, co uniemo\u017Cliwia im wzrost i namna\u017Canie si\u0119. Najcz\u0119stsze skutki uboczne: \n* zm\u0119czenie i os\u0142abienie, \n* zaburzenie funkcji krwiotw\u00F3rczej szpiku kostnego (spadek liczby bia\u0142ych i czerwonych krwinek oraz p\u0142ytek krwi), \n* md\u0142o\u015Bci i wymioty oraz utrata , \n* prokarbazyna reaguje z alkoholem i niekt\u00F3rymi produktami spo\u017Cywczymi, powoduj\u0105c b\u00F3le g\u0142owy, trudno\u015Bci w oddychaniu, nadmierne pocenie, omdlenia, \n* objawy podobne jak w przypadku grypy (gor\u0105czka, dreszcze, pocenie, b\u00F3l), \n* bezp\u0142odno\u015B\u0107. Wraz z PCB nie nale\u017Cy przyjmowa\u0107 jakichkolwiek dost\u0119pnych bez recepty lek\u00F3w bez wcze\u015Bniejszej konsultacji z lekarzem. Prokarbazyna podobnie jak inne leki przeciwnowotworowe mo\u017Ce mie\u0107 negatywny wp\u0142yw na rozw\u00F3j p\u0142odu (wp\u0142yw teratogenny)."@pl . . . . . "Matulane, Natulan, Indicarb, others"@en . . . "671"^^ . . "4915"^^ . . . "\u30D7\u30ED\u30AB\u30EB\u30D0\u30B8\u30F3\uFF08Procarbazine\uFF09\u306F\u30DB\u30B8\u30AD\u30F3\u30EA\u30F3\u30D1\u816B\u3084\u81A0\u82BD\u816B\u306A\u3069\u306E\u60AA\u6027\u816B\u760D\u306B\u5BFE\u3059\u308B\u5316\u5B66\u7642\u6CD5\u306B\u7528\u3044\u308B\u30A2\u30EB\u30AD\u30EB\u5316\u5264\u7CFB\u306E\u6297\u60AA\u6027\u816B\u760D\u85AC\u3067\u3042\u308B\u3002\u809D\u81D3\u3067\u4EE3\u8B1D\u3055\u308C\u3066\u6D3B\u6027\u4F53\u3068\u306A\u308B\u3002\u4ED6\u306BMAO\u3092\u963B\u5BB3\u3059\u308B\u306E\u3067\u3001\u30A2\u30C9\u30EC\u30CA\u30EA\u30F3\u4F5C\u52D5\u85AC\u3001\u6297\u3046\u3064\u85AC\u3001\u30C1\u30E9\u30DF\u30F3\u306E\u4F5C\u7528\u304C\u5897\u5F37\u3055\u308C\u308B\u3002 WHO\u5FC5\u9808\u533B\u85AC\u54C1\u30E2\u30C7\u30EB\u30FB\u30EA\u30B9\u30C8\u306B\u53CE\u8F09\u3055\u308C\u3066\u3044\u308B\u3002"@ja . . . . "4746"^^ . "35"^^ . . "464214923"^^ . . . . . . . . "1321" . . . . . . "\u0628\u0631\u0648\u0643\u0627\u0631\u0628\u0627\u0632\u064A\u0646"@ar . "12"^^ . "changed"@en . "Procarbazin (Handelsname: Natulan\u00AE) ist ein Chemotherapeutikum, das zu der Gruppe der Alkylantien geh\u00F6rt. Es ist ein Prodrug, das in Azoprocarbazin umgewandelt wird. Die Metabolisierung erfolgt hepatisch und in den Erythrozyten. Der Arzneistoff wird unter anderem eingesetzt zur Behandlung von Morbus Hodgkin, Non-Hodgkin-Lymphomen, zerebralen Neoplasien und bei einer bestimmten Form des Lungenkrebses, dem kleinzelligen Bronchialkarzinom. H\u00E4ufige Nebenwirkungen sind die Entstehung eines Mangel an wei\u00DFen Blutk\u00F6rperchen (Leukozyten) und Blutpl\u00E4ttchen (Thrombozyten), sogenannten Leukopenien beziehungsweise Thrombozytopenien. Dar\u00FCber hinaus kann es unter anderem zu \u00DCbelkeit, Erbrechen, Sterilit\u00E4t und Sensibilit\u00E4tsst\u00F6rungen kommen. Procarbazin wurde auch kausal mit Pleuraerguss in Verbindung gebracht."@de . . . . . . . . "La procarbazine est un m\u00E9dicament de la classe des agents alkylants antin\u00E9oplasiques utilis\u00E9 en chimioth\u00E9rapie contre le lymphome de Hodgkin, le carcinome pulmonaire \u00E0 petites cellules et certains cancers du cerveau tels que le glioblastome multiforme. Elle est m\u00E9tabolis\u00E9e et activ\u00E9e dans le foie. Elle inhibe \u00E9galement faiblement la monoamine oxydase, ce qui a pour effet d'accro\u00EEtre les effets des sympathicomim\u00E9tiques, des antid\u00E9presseurs tricycliques et de la tyramine. Le traitement du lymphome de Hodgkin fait souvent intervenir la procarbazine dans le cadre du protocole (en), lequel comprend la bl\u00E9omycine, l'\u00E9toposide, la doxorubicine (adriamycine), le cyclophosphamide, la vincristine (oncovin), la prednisone et la procarbazine. La premi\u00E8re association de chimioth\u00E9rapies pour traiter le lymphome de Hodgkin faisait \u00E9galement intervenir la procarbazine dans le cadre du protocole (en), qui comprenait la chlorm\u00E9thine (m\u00E9chlor\u00E9thamine), la vincristine (oncovin), la prednisone et la procarbazine. Par ailleurs, lorsqu'elle est utilis\u00E9e dans la prise en charge de certains cancers du cerveau tels que les gliomes malins, elle est souvent associ\u00E9e \u00E0 la lomustine et \u00E0 la vincristine (association appel\u00E9e PCV). La procarbazine est un inhibiteur du cytochrome P450 microsomial, ce qui accro\u00EEt l'effet des barbituriques, des ph\u00E9nothiazines et des narcotiques. \u00C9tant \u00E9galement un inhibiteur de monoamine oxydase, elle ne doit pas \u00EAtre associ\u00E9e \u00E0 la plupart des antid\u00E9presseurs ni \u00E0 certains antimigraineux ; elle peut induire une pouss\u00E9e d'hypertension art\u00E9rielle apr\u00E8s l'absorption d'une alimentation riche en tyramine, par exemple des fromages m\u00FBrs. L'absorption simultan\u00E9e d'\u00E9thanol peut, chez certains patients, avoir un effet semblable \u00E0 celui du disulfirame. Elle fait partie de la liste des m\u00E9dicaments essentiels de l'Organisation mondiale de la sant\u00E9 (liste mise \u00E0 jour en avril 2013)."@fr . "Matulane, Natulan, Indicarb, others"@en . . "Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers. For Hodgkin's it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. It is typically taken by mouth. Procarbazine was approved for medical use in the United States in 1969. It is on the World Health Organization's List of Essential Medicines. In the United Kingdom a month of treatment cost the National Health Service 450 to 750 pounds."@en . . . "DB01168"@en . "\u041F\u0440\u043E\u043A\u0430\u0440\u0431\u0430\u0437\u0438\u043D \u2014 \u043F\u0440\u043E\u0442\u0438\u0432\u043E\u043E\u043F\u0443\u0445\u043E\u043B\u0435\u0432\u044B\u0439 \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442, \u0430\u043B\u043A\u0438\u043B\u0438\u0440\u0443\u044E\u0449\u0435\u0435 \u0441\u043E\u0435\u0434\u0438\u043D\u0435\u043D\u0438\u0435 \u0438\u0437 \u0433\u0440\u0443\u043F\u043F\u044B \u043C\u0435\u0442\u0438\u043B\u0433\u0438\u0434\u0440\u0430\u0437\u0438\u043D\u043E\u0432."@ru . . "Procarbazina es un agente alquilante indicado como quimioterapia en el tratamiento del linfoma de Hodgkin\u200B y algunos tipos de tumores cerebrales, tal como el glioblastoma multiforme. Su mecanismo de acci\u00F3n consiste en unirse de forma covalente al DNA, para inhibir el crecimiento de las c\u00E9lulas cancerosas de forma no selectiva. La procarbazina es miembro del grupo de agentes alquilantes, es metabolizado y activado en el h\u00EDgado y se sabe que tiene capacidad de inhibir la monoamino oxidasa, aumentando as\u00ED los efectos de medicamentos simpaticomim\u00E9ticos, antidepresivos tric\u00EDclicos y el neurotransmisor tiramina. La procarbazina tambi\u00E9n puede causar una reacci\u00F3n tipo disulfiram con la ingesta concomitante de alcohol. El uso de procarbazina puede aumentar el riesgo de la aparici\u00F3n de ciertas leuce"@es . "L01"@en . "35S93Y190K" . . . . . . . . "71417" . "180"^^ . . . . . "a682094" . . "1321"^^ . "D"@en . . . "Procarbazin"@de . . "By mouth , intravenous"@en . . . . . "N-Isopropyl-4-[methyl]benzamide"@en . . "71417"^^ . "1098089699"^^ . "Rx-only"@en . "Procarbazina es un agente alquilante indicado como quimioterapia en el tratamiento del linfoma de Hodgkin\u200B y algunos tipos de tumores cerebrales, tal como el glioblastoma multiforme. Su mecanismo de acci\u00F3n consiste en unirse de forma covalente al DNA, para inhibir el crecimiento de las c\u00E9lulas cancerosas de forma no selectiva. La procarbazina es miembro del grupo de agentes alquilantes, es metabolizado y activado en el h\u00EDgado y se sabe que tiene capacidad de inhibir la monoamino oxidasa, aumentando as\u00ED los efectos de medicamentos simpaticomim\u00E9ticos, antidepresivos tric\u00EDclicos y el neurotransmisor tiramina. La procarbazina tambi\u00E9n puede causar una reacci\u00F3n tipo disulfiram con la ingesta concomitante de alcohol. El uso de procarbazina puede aumentar el riesgo de la aparici\u00F3n de ciertas leucemias, especialmente en la combinaci\u00F3n con mecloretamina, vincristina y prednisona.\u200B Este f\u00E1rmaco es un componente de la quimioterapia de combinaci\u00F3n MOPP."@es . . . "DB01168" . . . . "\u30D7\u30ED\u30AB\u30EB\u30D0\u30B8\u30F3"@ja . . "11145"^^ . "Prokarbazyna (PCB) \u2013 organiczny zwi\u0105zek chemiczny, lek przeciwnowotworowy, inhibitor replikacji DNA. Blokuje wytwarzanie bia\u0142ek i DNA przez kom\u00F3rki nowotworu poprzez degradacj\u0119 matrycy DNA, co uniemo\u017Cliwia im wzrost i namna\u017Canie si\u0119. Najcz\u0119stsze skutki uboczne: Wraz z PCB nie nale\u017Cy przyjmowa\u0107 jakichkolwiek dost\u0119pnych bez recepty lek\u00F3w bez wcze\u015Bniejszej konsultacji z lekarzem. Prokarbazyna podobnie jak inne leki przeciwnowotworowe mo\u017Ce mie\u0107 negatywny wp\u0142yw na rozw\u00F3j p\u0142odu (wp\u0142yw teratogenny)."@pl . . . . . . . . "\u041F\u0440\u043E\u043A\u0430\u0440\u0431\u0430\u0437\u0438\u043D"@ru . . . . "\u30D7\u30ED\u30AB\u30EB\u30D0\u30B8\u30F3\uFF08Procarbazine\uFF09\u306F\u30DB\u30B8\u30AD\u30F3\u30EA\u30F3\u30D1\u816B\u3084\u81A0\u82BD\u816B\u306A\u3069\u306E\u60AA\u6027\u816B\u760D\u306B\u5BFE\u3059\u308B\u5316\u5B66\u7642\u6CD5\u306B\u7528\u3044\u308B\u30A2\u30EB\u30AD\u30EB\u5316\u5264\u7CFB\u306E\u6297\u60AA\u6027\u816B\u760D\u85AC\u3067\u3042\u308B\u3002\u809D\u81D3\u3067\u4EE3\u8B1D\u3055\u308C\u3066\u6D3B\u6027\u4F53\u3068\u306A\u308B\u3002\u4ED6\u306BMAO\u3092\u963B\u5BB3\u3059\u308B\u306E\u3067\u3001\u30A2\u30C9\u30EC\u30CA\u30EA\u30F3\u4F5C\u52D5\u85AC\u3001\u6297\u3046\u3064\u85AC\u3001\u30C1\u30E9\u30DF\u30F3\u306E\u4F5C\u7528\u304C\u5897\u5F37\u3055\u308C\u308B\u3002 WHO\u5FC5\u9808\u533B\u85AC\u54C1\u30E2\u30C7\u30EB\u30FB\u30EA\u30B9\u30C8\u306B\u53CE\u8F09\u3055\u308C\u3066\u3044\u308B\u3002"@ja . "19"^^ . . . . "600.0"^^ . . "4915" . . . . "Procarbazin (Handelsname: Natulan\u00AE) ist ein Chemotherapeutikum, das zu der Gruppe der Alkylantien geh\u00F6rt. Es ist ein Prodrug, das in Azoprocarbazin umgewandelt wird. Die Metabolisierung erfolgt hepatisch und in den Erythrozyten. Der Arzneistoff wird unter anderem eingesetzt zur Behandlung von Morbus Hodgkin, Non-Hodgkin-Lymphomen, zerebralen Neoplasien und bei einer bestimmten Form des Lungenkrebses, dem kleinzelligen Bronchialkarzinom. Procarbazin wurde auch kausal mit Pleuraerguss in Verbindung gebracht."@de . "La procarbazine est un m\u00E9dicament de la classe des agents alkylants antin\u00E9oplasiques utilis\u00E9 en chimioth\u00E9rapie contre le lymphome de Hodgkin, le carcinome pulmonaire \u00E0 petites cellules et certains cancers du cerveau tels que le glioblastome multiforme. Elle est m\u00E9tabolis\u00E9e et activ\u00E9e dans le foie. Elle inhibe \u00E9galement faiblement la monoamine oxydase, ce qui a pour effet d'accro\u00EEtre les effets des sympathicomim\u00E9tiques, des antid\u00E9presseurs tricycliques et de la tyramine."@fr . . "La procarbazina \u00E8 un farmaco chemioterapico di tipo alchilante, usato principalmente nel linfoma di Hodgkin e certi tipi di tumori cerebrali come il glioblastoma multiforme. Agisce formando un legame covalente con il DNA impedendo cos\u00EC la duplicazione e crescita delle cellule cancerose e non. \u00C8 commercializzato con i nomi di: Matulane (USA), Natulan (Canada e Italia), Indicarb (India)."@it . . . . . . .