"La lipomatosi indica la presenza di molti lipomi nell\u2019organismo. \u00C8 una condizione genetica, probabilmente con trasmissione autosomica dominante. I lipomi sono ben distinti tra loro e dai margini netti. Generalmente sono molti e pi\u00F9 frequenti a livello del tronco e degli arti, mentre sono meno diffusi a livello della testa e delle spalle. Nel 1993, un polimorfismo genetico alla base dello sviluppo dei lipomi fu individuato nel cromosoma 12, sul locus genico 12q15, dove il gene HMGIC codifica per l'isoforma I-C della proteina HMGIC. Questa \u00E8 la mutazione genetica pi\u00F9 frequentemente osservata nei pazienti con lipoma singolo, ma la presenza di lipomi multipli deriva spesso da multiple mutazioni genetiche; tra queste, sono state osservate traslocazioni reciproche all'interno del cromosoma 12, tra il locus genico 12q13 e il 12q14. Nonostante la prognosi della lipomatosi sia benigna, la condizione pi\u00F9 provocare dolore anche molto intenso, a seconda della sede di sviluppo dei lipomi. Questi tumori benigni possono essere rimossi mediante semplice, escissione mediante endoscopia o liposuzione. sindromi specifiche che nel loro quadro clinico annoverano la lipomatosi sono la sindrome di Proteo, la sindrome di Cowden e altre amartomatosi multiple dovuti a mutazioni del gene PTEN; altre cause della condizione sono la , la sindrome di Dercum, la lipodistrofia familiare, , iniezione di steroidi per via epidurale e vari tipi di ereditaria."@it . "La lipomatose est un syndrome h\u00E9r\u00E9ditaire relativement rare, qui se caract\u00E9rise par la pr\u00E9sence de plusieurs lipomes sur la surface du corps. \n* Portail de la m\u00E9decine"@fr . "1113871244"^^ . . . . "La lipomatose est un syndrome h\u00E9r\u00E9ditaire relativement rare, qui se caract\u00E9rise par la pr\u00E9sence de plusieurs lipomes sur la surface du corps. \n* Portail de la m\u00E9decine"@fr . "151900"^^ . . . . . "D008068" . . "3184819"^^ . . . . "Lipomatosi"@it . . "Die Lipomatose (lat.: Lipomatosis) ist bei Menschen und Tieren eine diffuse Zunahme des Fettgewebes (Fettgewebshyperplasie) an bestimmten Stellen des K\u00F6rpers. So kann der obere Stamm, die H\u00FCften und das K\u00F6rperinnere betroffen sein (zum Beispiel das Herz bei der Lipomatosis cordis). Abzugrenzen ist die Lipomatosis dolorosa (Dercum\u2019sche Krankheit), sie ist eine besonders bei Frauen im Klimakterium vorkommende Krankheit, die durch das Auftreten zahlreicher kleinerer schmerzhafter Fettgewebsgeschw\u00FClste gekennzeichnet ist."@de . . "Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders. In 1993, a genetic polymorphism within lipomas was localized to chromosome 12q15, where the gene encodes the high-mobility-group protein isoform I-C. This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within."@en . . . "Lipomatosis"@en . . . . "Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders. In 1993, a genetic polymorphism within lipomas was localized to chromosome 12q15, where the gene encodes the high-mobility-group protein isoform I-C. This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within. Although this condition is benign, it can sometimes be very painful depending on location of the lipomas. Some patients who are concerned with cosmetics seek removal of individual lipomas. Removal can include simple excision, endoscopic removal, or liposuction. Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease), Dercum's Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis, and familial angiolipomatosis."@en . "Lipomatosis"@en . . . . . ""@en . . "Mediastinal lipomatosis"@en . "La lipomatosi indica la presenza di molti lipomi nell\u2019organismo. \u00C8 una condizione genetica, probabilmente con trasmissione autosomica dominante. I lipomi sono ben distinti tra loro e dai margini netti. Generalmente sono molti e pi\u00F9 frequenti a livello del tronco e degli arti, mentre sono meno diffusi a livello della testa e delle spalle. Nel 1993, un polimorfismo genetico alla base dello sviluppo dei lipomi fu individuato nel cromosoma 12, sul locus genico 12q15, dove il gene HMGIC codifica per l'isoforma I-C della proteina HMGIC. Questa \u00E8 la mutazione genetica pi\u00F9 frequentemente osservata nei pazienti con lipoma singolo, ma la presenza di lipomi multipli deriva spesso da multiple mutazioni genetiche; tra queste, sono state osservate traslocazioni reciproche all'interno del cromosoma 12, t"@it . "E88.2" . . . . . . "\u062F\u0627\u0621 \u0634\u062D\u0645\u064A"@ar . "151900"^^ . "Lipomatose"@fr . "Lipomatosis"@en . . . "D008068"@en . 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\u0648\u0645\u0631\u0636 \u062F\u064A\u0631\u0643\u0648\u0645 \u0648\u0627\u0644\u062D\u062B\u0644 \u0627\u0644\u0634\u062D\u0645\u064A \u0627\u0644\u0639\u0627\u0626\u0644\u064A \u0648\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0633\u0628\u0627\u062A\u064A\u0629 \u0648\u062D\u0642\u0646 \u0627\u0644\u0633\u062A\u064A\u0631\u0648\u064A\u062F \u0641\u0648\u0642 \u0627\u0644\u062C\u0627\u0641\u064A\u0629 \u0645\u0639 \u0648 \u0648\u0631\u0645 \u0648\u0639\u0627\u0626\u064A \u0639\u0627\u0626\u0644\u064A (amilial angiolipomatosis)."@ar . . "4435"^^ . . . . . . . . "37095002"^^ . "Die Lipomatose (lat.: Lipomatosis) ist bei Menschen und Tieren eine diffuse Zunahme des Fettgewebes (Fettgewebshyperplasie) an bestimmten Stellen des K\u00F6rpers. So kann der obere Stamm, die H\u00FCften und das K\u00F6rperinnere betroffen sein (zum Beispiel das Herz bei der Lipomatosis cordis). Abzugrenzen ist die Lipomatosis dolorosa (Dercum\u2019sche Krankheit), sie ist eine besonders bei Frauen im Klimakterium vorkommende Krankheit, die durch das Auftreten zahlreicher kleinerer schmerzhafter Fettgewebsgeschw\u00FClste gekennzeichnet ist."@de . "Lipomatose"@de . . . "E88.2"@en . . . 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