@prefix rdf: . @prefix yago: . rdf:type yago:Thing100002452 , yago:Compound114818238 , yago:Molecule114682133 , yago:Protein114728724 , yago:Substance100019613 , yago:WikicatNucleicAcids , yago:Macromolecule114944888 , yago:Matter100020827 . @prefix owl: . rdf:type owl:Thing , yago:PhysicalEntity100001930 , yago:OrganicCompound114727670 , yago:Material114580897 . @prefix dbo: . rdf:type dbo:Election , yago:Unit109465459 , yago:Chemical114806838 , yago:Abstraction100002137 , yago:WikicatProteins , yago:NucleicAcid114964129 , yago:Part113809207 , yago:Relation100031921 . @prefix rdfs: . rdfs:label "Denaturazione delle proteine"@it , "\u5909\u6027"@ja , "Denaturatie (biochemie)"@nl , "Denaturasi"@in , "\u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0438\u044F \u0431\u0435\u043B\u043A\u043E\u0432"@ru , "\uBCC0\uC131 (\uC0DD\uD654\uD559)"@ko , "Denaturace"@cs , "D\u00E9naturation"@fr , "Denaturi\u011Do de proteinoj"@eo , "Denaturacja bia\u0142ka"@pl , "Denaturation (biochemistry)"@en , "Desnatura\u00E7\u00E3o"@pt , "\u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0456\u044F (\u0431\u0456\u043E\u0445\u0456\u043C\u0456\u044F)"@uk , "Desnaturalizaci\u00F3n (bioqu\u00EDmica)"@es , "\u0625\u0641\u0633\u0627\u062F (\u0643\u064A\u0645\u064A\u0627\u0621 \u062D\u064A\u0648\u064A\u0629)"@ar , "\u53D8\u6027 (\u751F\u7269\u5316\u5B66)"@zh , "Desnaturalitzaci\u00F3"@ca , "Desnaturalizazio"@eu , "Denaturierung (Biochemie)"@de , "\u039C\u03B5\u03C4\u03BF\u03C5\u03C3\u03AF\u03C9\u03C3\u03B7"@el , "Denaturering"@sv ; rdfs:comment "\u5909\u6027\uFF08\u3078\u3093\u305B\u3044\u3001\u82F1\u8A9E\uFF1Adenaturation\uFF09\u3068\u306F\u3001\u6027\u8CEA\u304C\u5909\u5316\u3059\u308B\u3053\u3068\u3002\u7279\u306B\u7570\u5E38\u306B\u5909\u5316\u3059\u308B\u5834\u5408\u3092\u6307\u3059\u3053\u3068\u304C\u3042\u308B\u3002\u307E\u305F\u3001\u305D\u306E\u5909\u5316\u3057\u305F\u6027\u8CEA\u305D\u306E\u3082\u306E\u3092\u6307\u3059\u3002"@ja , "\u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0438\u044F \u0431\u0435\u043B\u043A\u043E\u0432 (\u043B\u0430\u0442. denaturatus \u2014 \u043B\u0438\u0448\u0451\u043D\u043D\u044B\u0439 \u043F\u0440\u0438\u0440\u043E\u0434\u043D\u044B\u0445 \u0441\u0432\u043E\u0439\u0441\u0442\u0432; \u043E\u0442 de- \u2014 \u043F\u0440\u0438\u0441\u0442\u0430\u0432\u043A\u0430, \u043E\u0437\u043D\u0430\u0447\u0430\u044E\u0449\u0430\u044F \u043E\u0442\u0434\u0435\u043B\u0435\u043D\u0438\u0435, \u0443\u0434\u0430\u043B\u0435\u043D\u0438\u0435 + natura \u2014 \u043F\u0440\u0438\u0440\u043E\u0434\u0430, \u0435\u0441\u0442\u0435\u0441\u0442\u0432\u043E) \u2014 \u0438\u0437\u043C\u0435\u043D\u0435\u043D\u0438\u0435 \u043D\u0430\u0442\u0438\u0432\u043D\u043E\u0439 \u043A\u043E\u043D\u0444\u043E\u0440\u043C\u0430\u0446\u0438\u0438 \u0431\u0435\u043B\u043A\u043E\u0432\u043E\u0439 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044B \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u0440\u0430\u0437\u043B\u0438\u0447\u043D\u044B\u0445 \u0434\u0435\u0441\u0442\u0430\u0431\u0438\u043B\u0438\u0437\u0438\u0440\u0443\u044E\u0449\u0438\u0445 \u0444\u0430\u043A\u0442\u043E\u0440\u043E\u0432. \u0410\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442\u043D\u0430\u044F \u043F\u043E\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u0442\u0435\u043B\u044C\u043D\u043E\u0441\u0442\u044C \u0431\u0435\u043B\u043A\u0430 \u043D\u0435 \u0438\u0437\u043C\u0435\u043D\u044F\u0435\u0442\u0441\u044F. \u041F\u0440\u0438\u0432\u043E\u0434\u0438\u0442 \u043A \u043F\u043E\u0442\u0435\u0440\u0435 \u0431\u0435\u043B\u043A\u0430\u043C\u0438 \u0438\u0445 \u0435\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043D\u043D\u044B\u0445 \u0441\u0432\u043E\u0439\u0441\u0442\u0432 (\u0440\u0430\u0441\u0442\u0432\u043E\u0440\u0438\u043C\u043E\u0441\u0442\u0438, \u0433\u0438\u0434\u0440\u043E\u0444\u0438\u043B\u044C\u043D\u043E\u0441\u0442\u0438 \u0438 \u0434\u0440.). \u041F\u0440\u043E\u0446\u0435\u0441\u0441 \u0434\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0438\u0438 \u043E\u0442\u0434\u0435\u043B\u044C\u043D\u043E\u0439 \u0431\u0435\u043B\u043A\u043E\u0432\u043E\u0439 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044B, \u043F\u0440\u0438\u0432\u043E\u0434\u044F\u0449\u0438\u0439 \u043A \u0440\u0430\u0441\u043F\u0430\u0434\u0443 \u0435\u0451 \u00AB\u0436\u0451\u0441\u0442\u043A\u043E\u0439\u00BB \u0442\u0440\u0451\u0445\u043C\u0435\u0440\u043D\u043E\u0439 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u044B, \u0438\u043D\u043E\u0433\u0434\u0430 \u043D\u0430\u0437\u044B\u0432\u0430\u044E\u0442 \u043F\u043B\u0430\u0432\u043B\u0435\u043D\u0438\u0435\u043C \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044B."@ru , "En bioqu\u00EDmica, la desnaturalitzaci\u00F3 \u00E9s un canvi estructural de les prote\u00EFnes o \u00E0cids nucleics, on perden la seva estructura terci\u00E0ria i estructura secund\u00E0ria, per haver aplicat una for\u00E7a externa o compost qu\u00EDmic, com pot ser un \u00E0cid fort o una base qu\u00EDmica, una sal inorg\u00E0nica concentrada o un solvent (per exemple alcohol o cloroform) o la calor. Si les prote\u00EFnes en un organisme viu es desnaturalitzen aix\u00F2 resulta en una interrupci\u00F3 de l'activitat cel\u00B7lular i possiblement la mort cel\u00B7lular. Les prote\u00EFnes desnaturalitzades poden mostrar una ampli rang de caracter\u00EDstiques, des de la p\u00E8rdua de la solubilitat a l'agregaci\u00F3."@ca , "\u53D8\u6027\uFF08\u82F1\u8A9E\uFF1ADenaturation\uFF09\u5728\u751F\u7269\u5316\u5B66\u4E2D\u662F\u6307\u86CB\u767D\u8D28\u6216\u6838\u9178\u53D7\u5230\u67D0\u4E9B\u7406\u5316\u56E0\u7D20\u7684\u4F5C\u7528\uFF0C\u5176\u9AD8\u7EA7\u7ED3\u6784\u53D1\u751F\u7834\u574F\u4ECE\u800C\u4E27\u5931\u751F\u7269\u6D3B\u6027\u7684\u73B0\u8C61\u3002"@zh , "En biochimie, la d\u00E9naturation est le processus par lequel une macromol\u00E9cule biologique, acide nucl\u00E9ique ou prot\u00E9ine, perd sa conformation tridimensionnelle normale : les prot\u00E9ines perdent leur repliement et se d\u00E9plient, les deux brins appari\u00E9s des duplex d'acides nucl\u00E9iques se s\u00E9parent. Cette conformation tridimensionnelle est le plus souvent n\u00E9cessaire pour que les macromol\u00E9cules biologiques puissent remplir leur fonction et donc la d\u00E9naturation inactive en g\u00E9n\u00E9ral ces macromol\u00E9cules biologiques."@fr , "In biochemistry, denaturation is a process in which proteins or nucleic acids lose the quaternary structure, tertiary structure, and secondary structure which is present in their native state, by application of some external stress or compound such as a strong acid or base, a concentrated inorganic salt, an organic solvent (e.g., alcohol or chloroform), agitation and radiation or heat. If proteins in a living cell are denatured, this results in disruption of cell activity and possibly cell death. Protein denaturation is also a consequence of cell death. Denatured proteins can exhibit a wide range of characteristics, from conformational change and loss of solubility to aggregation due to the exposure of hydrophobic groups. The loss of solubility as a result of denaturation is called coagula"@en , "\u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0301\u0446\u0456\u044F \u2014 \u043F\u043E\u0440\u0443\u0448\u0435\u043D\u043D\u044F \u0432\u0438\u0441\u043E\u043A\u043E\u0440\u0456\u0432\u043D\u0435\u0432\u043E\u0457 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0438 \u043C\u0430\u043A\u0440\u043E\u043C\u043E\u043B\u0435\u043A\u0443\u043B (\u0437\u0430\u0437\u0432\u0438\u0447\u0430\u0439 \u0431\u0456\u043B\u043A\u0456\u0432 \u0430\u0431\u043E \u043D\u0443\u043A\u043B\u0435\u0457\u043D\u043E\u0432\u0438\u0445 \u043A\u0438\u0441\u043B\u043E\u0442) \u0443 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0456 \u0435\u043A\u0441\u0442\u0440\u0435\u043C\u0430\u043B\u044C\u043D\u0438\u0445 \u0443\u043C\u043E\u0432 \u043D\u0430\u0432\u043A\u043E\u043B\u0438\u0448\u043D\u044C\u043E\u0433\u043E \u0441\u0435\u0440\u0435\u0434\u043E\u0432\u0438\u0449\u0430, \u043D\u0430\u043F\u0440\u0438\u043A\u043B\u0430\u0434, \u043E\u0431\u0440\u043E\u0431\u043A\u0438 \u043A\u0438\u0441\u043B\u043E\u0442\u0430\u043C\u0438 \u0430\u0431\u043E \u043E\u0441\u043D\u043E\u0432\u0430\u043C\u0438, \u0432\u0438\u0441\u043E\u043A\u0438\u043C\u0438 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044F\u043C\u0438 \u043D\u0435\u043E\u0440\u0433\u0430\u043D\u0456\u0447\u043D\u0438\u0445 \u0441\u043E\u043B\u0435\u0439 \u0430\u0431\u043E \u043E\u0440\u0433\u0430\u043D\u0456\u0447\u043D\u0438\u0445 \u0440\u043E\u0437\u0447\u0438\u043D\u043D\u0438\u043A\u0456\u0432 (\u0441\u043F\u0438\u0440\u0442, \u0445\u043B\u043E\u0440\u043E\u0444\u043E\u0440\u043C), \u043D\u0430\u0433\u0440\u0456\u0432\u0430\u043D\u043D\u044F. \u0423 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0456 \u043C\u0430\u043A\u0440\u043E\u043C\u043E\u043B\u0435\u043A\u0443\u043B\u0430 \u0432\u0442\u0440\u0430\u0447\u0430\u0454 \u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u0442\u0430\u043D \u0442\u0430 \u043D\u0435\u043E\u0431\u0445\u0456\u0434\u043D\u0456 \u0432\u043B\u0430\u0441\u0442\u0438\u0432\u043E\u0441\u0442\u0456 \u0434\u043B\u044F \u0444\u0443\u043D\u043A\u0446\u0456\u043E\u043D\u0443\u0432\u0430\u043D\u043D\u044F \u0432 \u043A\u043B\u0456\u0442\u0438\u043D\u0456. \u0414\u0435\u043D\u0430\u0442\u0443\u0440\u043E\u0432\u0430\u043D\u0456 \u0431\u0456\u043B\u043A\u0438 \u043F\u0440\u043E\u044F\u0432\u043B\u044F\u044E\u0442\u044C \u0448\u0438\u0440\u043E\u043A\u0438\u0439 \u0440\u044F\u0434 \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043A, \u0432\u0456\u0434 \u0432\u0442\u0440\u0430\u0442\u0438 \u0440\u043E\u0437\u0447\u0438\u043D\u043D\u043E\u0441\u0442\u0456 \u0434\u043E \u0430\u0433\u0440\u0435\u0433\u0430\u0446\u0456\u0457."@uk , "Denaturace je v biochemii vratn\u00FD nebo nevratn\u00FD proces, p\u0159i n\u011Bm\u017E \u00FA\u010Dinkem jist\u00FDch fyzik\u00E1ln\u00EDch \u010Di chemick\u00FDch zm\u011Bn doch\u00E1z\u00ED k zm\u011Bn\u00E1m prostorov\u00E9 struktury n\u011Bkter\u00FDch biomolekul z p\u016Fvodn\u00EDho p\u0159irozen\u00E9ho stavu. Denaturovat mohou b\u00EDlkoviny, ale i dvouvl\u00E1knov\u00E9 nukleov\u00E9 kyseliny (zejm\u00E9na DNA), p\u0159i\u010Dem\u017E oba tyto procesy se fundament\u00E1ln\u011B li\u0161\u00ED. Denaturace b\u00EDlkovin je prov\u00E1zena ztr\u00E1tou jejich prostorov\u00E9 sekund\u00E1rn\u00ED struktury, p\u0159i\u010Dem\u017E \u010Dasto doch\u00E1z\u00ED ke ztr\u00E1t\u011B rozpustnosti (k precipitaci). U dvouvl\u00E1knov\u00E9 DNA se denaturace projevuje jako odd\u011Blen\u00ED komplement\u00E1rn\u00EDch vl\u00E1ken v dvou\u0161roubovici."@cs , "\u03A4\u03CC\u03C3\u03BF \u03C3\u03C4\u03B7 \u039C\u03BF\u03C1\u03B9\u03B1\u03BA\u03AE \u0392\u03B9\u03BF\u03BB\u03BF\u03B3\u03AF\u03B1 \u03CC\u03C3\u03BF \u03BA\u03B1\u03B9 \u03C3\u03C4\u03B7 \u0392\u03B9\u03BF\u03C7\u03B7\u03BC\u03B5\u03AF\u03B1 \u03BC\u03B5 \u03C4\u03BF\u03BD \u03CC\u03C1\u03BF \u03BC\u03B5\u03C4\u03BF\u03C5\u03C3\u03AF\u03C9\u03C3\u03B7, \u03C7\u03B1\u03C1\u03B1\u03BA\u03C4\u03B7\u03C1\u03AF\u03B6\u03B5\u03C4\u03B1\u03B9 \u03C4\u03BF \u03C6\u03B1\u03B9\u03BD\u03CC\u03BC\u03B5\u03BD\u03BF \u03C4\u03B7\u03C2 \u03B4\u03B9\u03AC\u03C3\u03C0\u03B1\u03C3\u03B7\u03C2 \u03C4\u03C9\u03BD \u03B4\u03B5\u03C3\u03BC\u03CE\u03BD, \u03C3\u03C4\u03B7 \u03B4\u03B5\u03C5\u03C4\u03B5\u03C1\u03BF\u03C4\u03B1\u03B3\u03AE, \u03C4\u03C1\u03B9\u03C4\u03BF\u03C4\u03B1\u03B3\u03AE \u03AE \u03C4\u03B5\u03C4\u03B1\u03C1\u03C4\u03BF\u03C4\u03B1\u03B3\u03AE \u03B4\u03BF\u03BC\u03AE \u03BA\u03B1\u03B9 \u03B4\u03B5\u03BD \u03B1\u03BD\u03B1\u03C6\u03AD\u03C1\u03B5\u03C4\u03B1\u03B9 \u03C3\u03B5 \u03B1\u03BB\u03BB\u03B1\u03B3\u03AD\u03C2 \u03C4\u03B7\u03C2 \u03C0\u03C1\u03C9\u03C4\u03BF\u03C4\u03B1\u03B3\u03BF\u03CD\u03C2 \u03B4\u03BF\u03BC\u03AE\u03C2, \u03C4\u03C9\u03BD \u03C0\u03C1\u03C9\u03C4\u03B5\u03CA\u03BD\u03CE\u03BD \u03BA\u03B1\u03B9 \u03C4\u03C9\u03BD \u03BD\u03BF\u03C5\u03BA\u03BB\u03B5\u03CA\u03BA\u03CE\u03BD \u03BF\u03BE\u03AD\u03C9\u03BD. \u039A\u03B1\u03C4\u03AC \u03C4\u03B7 \u03BC\u03B5\u03C4\u03BF\u03C5\u03C3\u03AF\u03C9\u03C3\u03B7 \u03BF\u03B9 \u03B4\u03B5\u03C3\u03BC\u03BF\u03AF \u03C0\u03BF\u03C5 \u03AD\u03C7\u03BF\u03C5\u03BD \u03B1\u03BD\u03B1\u03C0\u03C4\u03C5\u03C7\u03B8\u03B5\u03AF \u03BC\u03B5\u03C4\u03B1\u03BE\u03CD \u03C4\u03C9\u03BD \u03C0\u03BB\u03B5\u03C5\u03C1\u03B9\u03BA\u03CE\u03BD \u03BF\u03BC\u03AC\u03B4\u03C9\u03BD \u03C4\u03C9\u03BD \u03B1\u03BC\u03B9\u03BD\u03BF\u03BE\u03AD\u03C9\u03BD \u03C3\u03C0\u03AC\u03B6\u03BF\u03C5\u03BD, (\u03B1\u03C0\u03BF\u03BA\u03CC\u03C0\u03C4\u03BF\u03BD\u03C4\u03B1\u03B9), \u03BC\u03B5 \u03C3\u03C5\u03BD\u03AD\u03C0\u03B5\u03B9\u03B1 \u03C4\u03B7\u03BD \u03BA\u03B1\u03C4\u03B1\u03C3\u03C4\u03C1\u03BF\u03C6\u03AE \u03C4\u03B7\u03C2 \u03C4\u03C1\u03B9\u03C3\u03B4\u03B9\u03AC\u03C3\u03C4\u03B1\u03C4\u03B7\u03C2 \u03B4\u03BF\u03BC\u03AE\u03C2 \u03C4\u03B7\u03C2 \u03C0\u03C1\u03C9\u03C4\u03B5\u0390\u03BD\u03B7\u03C2 \u03BA\u03B1\u03B9 \u03BD\u03B1 \u03C7\u03AC\u03BD\u03B5\u03B9 \u03AD\u03C4\u03C3\u03B9 \u03C4\u03B7 \u03BB\u03B5\u03B9\u03C4\u03BF\u03C5\u03C1\u03B3\u03B9\u03BA\u03CC\u03C4\u03B7\u03C4\u03AC \u03C4\u03B7\u03C2."@el , "Denaturasi atau pengawaaslian adalah sebuah proses di mana protein atau asam nukleat kehilangan struktur tersier dan struktur sekunder dengan penerapan beberapa tekanan eksternal atau senyawa, seperti asam kuat atau basa, garam anorganik terkonsentrasi, sebuah misalnya pelarut organik (cth, alkohol atau kloroform), atau panas. Jika protein dalam sel hidup didenaturasi, ini menyebabkan gangguan terhadap aktivitas sel dan kemungkinan kematian sel. protein didenaturasi dapat menunjukkan berbagai karakteristik, dari hilangnya kelarutan untuk agregasi komunal. Denaturisasi dalam pengertian ini tidak digunakan dalam penyusunan bahan kimia industri alkohol didenaturasi."@in , "Denaturierung bezeichnet eine strukturelle Ver\u00E4nderung von Biomolek\u00FClen wie Proteinen (Eiwei\u00DFe) oder Desoxyribonukleins\u00E4ure (DNS), die in den meisten F\u00E4llen mit einem Verlust der biologischen Funktion dieser Molek\u00FCle verbunden ist, obgleich deren Prim\u00E4rstruktur unver\u00E4ndert bleibt. Eine Denaturierung kann auf physikalische oder auf chemische Einfl\u00FCsse zur\u00FCckzuf\u00FChren sein."@de , "Denaturacja bia\u0142ka \u2013 zmiany w II, III- i IV-rz\u0119dowej strukturze bia\u0142ka natywnego (w przeciwie\u0144stwie do wysalania, podczas kt\u00F3rego bia\u0142ka wytr\u0105caj\u0105 si\u0119 bez utraty struktury), kt\u00F3re prowadz\u0105 do utraty aktywno\u015Bci biologicznej lub innej indywidualnej cechy charakterystycznej przy zachowaniu sekwencji aminokwas\u00F3w. Podczas denaturacji niszczone s\u0105 wi\u0105zania wodorowe, a w obecno\u015Bci odczynnik\u00F3w redukuj\u0105cych zerwaniu ulegaj\u0105 mostki dwusiarczkowe."@pl , "La denaturazione delle proteine \u00E8 un fenomeno chimico che consiste nel cambiamento della struttura proteica nativa, con conseguente perdita della funzione originaria della molecola. La denaturazione \u00E8 un processo che porta alla perdita di ordine e quindi a un aumento di entropia. Dopo che una proteina ha cominciato a denaturarsi diviene sempre pi\u00F9 sensibile al processo, quindi la denaturazione \u00E8 un processo cooperativo. Non vengono compromessi i legami peptidici. La struttura primaria non viene modificata. In seguito alla denaturazione le proteine possono esporre e rendere reattivi alcuni gruppi funzionali tramite i quali formare dei legami intramolecolari (deboli o forti) che possono causare l'aggregazione di pi\u00F9 molecole proteiche."@it , "\uBCC0\uC131(\u8B8A\u6027, \uC601\uC5B4: denaturation)\uC740 \uB2E8\uBC31\uC9C8\uC774\uB098 \uD575\uC0B0\uC774 \uAC15\uD55C \uC0B0\uC774\uB098 \uC5FC\uAE30, \uC5F4, \uB18D\uCD95\uB41C \uBB34\uAE30\uC5FC, \uC720\uAE30\uC6A9\uC81C(\uC54C\uCF54\uC62C \uB610\uB294 \uD074\uB85C\uB85C\uD3EC\uB984), \uBC29\uC0AC\uC120\uACFC \uAC19\uC740 \uC77C\uBD80 \uC678\uBD80 \uC790\uADF9\uC774\uB098 \uD654\uD569\uBB3C\uC744 \uC801\uC6A9\uD568\uC73C\uB85C\uC368 \uBCF8\uB798\uC758 \uC0C1\uD0DC\uC5D0 \uC874\uC7AC\uD558\uB294 2\uCC28 \uAD6C\uC870, 3\uCC28 \uAD6C\uC870, 4\uCC28 \uAD6C\uC870\uB97C \uC0C1\uC2E4\uD558\uB294 \uACFC\uC815\uC774\uB2E4. \uC0B4\uC544\uC788\uB294 \uC138\uD3EC\uC758 \uB2E8\uBC31\uC9C8\uC774 \uBCC0\uC131\uB418\uBA74 \uC138\uD3EC \uD65C\uC131\uC758 \uD30C\uAD34 \uBC0F \uC138\uD3EC \uC790\uC0B4\uC744 \uCD08\uB798\uD55C\uB2E4. \uB2E8\uBC31\uC9C8 \uBCC0\uC131\uC740 \uC138\uD3EC \uC790\uC0B4\uC758 \uACB0\uACFC\uC774\uB2E4. \uBCC0\uC131 \uB2E8\uBC31\uC9C8\uC740 \uC21C\uC751\uC801 \uBCC0\uD654 \uBC0F \uC6A9\uD574\uB825 \uC190\uC2E4\uC5D0\uC11C\uBD80\uD130 \uC18C\uC218\uC131 \uADF8\uB8F9\uC758 \uB178\uCD9C\uC5D0 \uC758\uD55C \uC9D1\uACC4\uC5D0 \uC774\uB974\uAE30\uAE4C\uC9C0 \uAD11\uBC94\uC704\uD55C \uD2B9\uC131\uC744 \uB098\uD0C0\uB0BC \uC218 \uC788\uB2E4. \uBCC0\uC131 \uB2E8\uBC31\uC9C8\uC740 3\uCC28\uC6D0 \uAD6C\uC870\uB97C \uC783\uAE30 \uB54C\uBB38\uC5D0 \uAE30\uB2A5\uC744 \uD560 \uC218 \uC5C6\uB2E4. \uB2E8\uBC31\uC9C8 \uC811\uD798\uC740 \uAD6C\uC0C1 \uB2E8\uBC31\uC9C8\uC774\uB098 \uB9C9 \uB2E8\uBC31\uC9C8\uC774 \uC81C\uB300\uB85C \uC791\uB3D9\uD560 \uC218 \uC788\uAC8C \uD558\uB294 \uC5F4\uC1E0\uC640 \uAC19\uC740 \uACFC\uC815\uC774\uB2E4. \uB2E8\uBC31\uC9C8\uC774 \uC791\uB3D9\uD558\uB824\uBA74 \uC62C\uBC14\uB978 \uBAA8\uC591\uC73C\uB85C \uC811\uD600\uC57C \uD55C\uB2E4. \uADF8\uB7EC\uB098 \uC811\uD798\uC5D0\uC11C \uD070 \uC5ED\uD560\uC744 \uD558\uB294 \uC218\uC18C \uACB0\uD569\uC740 \uC57D\uD574\uC11C \uC5F4, \uC0B0\uB3C4, \uB2E4\uC591\uD55C \uC5FC \uB18D\uB3C4 \uBC0F \uB2E8\uBC31\uC9C8\uC744 \uBCC0\uC131\uC2DC\uD0AC \uC218 \uC788\uB294 \uB2E4\uB978 \uC790\uADF9 \uC694\uC778\uC5D0 \uC758\uD574 \uC27D\uAC8C \uC601\uD5A5\uC744 \uBC1B\uB294\uB2E4. \uC774 \uAC1C\uB150\uC740 \uBCC0\uC131 \uC54C\uCF54\uC62C\uACFC \uAD00\uB828\uC774 \uC5C6\uC73C\uBA70, \uC774\uB294 \uC54C\uCF54\uC62C\uC774 \uC0AC\uB78C\uC758 \uC18C\uBE44\uC5D0 \uBD80\uC801\uD569\uD558\uB3C4\uB85D \uCCA8\uAC00\uC81C\uC640 \uD63C\uD569\uB41C \uC54C\uCF54\uC62C\uC774\uB2E4."@ko , "Denaturering, av latin de och natura, 'g\u00F6ra onaturlig', inneb\u00E4r rent generellt att ett \u00E4mnes beskaffenhet f\u00F6r\u00E4ndras s\u00E5 att det inte kan anv\u00E4ndas f\u00F6r ett specifikt \u00E4ndam\u00E5l. N\u00E4r ett \u00E4mne denatureras f\u00F6r\u00E4ndras strukturen eller egenskaperna i \u00E4mnet. Vid kemisk denaturering, vilket \u00E4r den vanligaste formen av denaturering, f\u00F6r\u00E4ndras ett proteins egenskaper samt f\u00F6rlorar proteinet sin biologiska funktion.. En annan anv\u00E4ndning av denaturering kan vara att denaturera tex handsprit med hj\u00E4lp av denatureringsmedlet isopropanol. Isopropanol \u00E4ndrar funktionen p\u00E5 handspriten vilket klassificeras som en slags denaturering."@sv , "En bioqu\u00EDmica, la desnaturalizaci\u00F3n es un cambio estructural de las prote\u00EDnas o \u00E1cidos nucleicos, donde pierden su estructura nativa, y de esta forma su \u00F3ptimo funcionamiento y a veces tambi\u00E9n cambian sus propiedades f\u00EDsico-qu\u00EDmicas-estructurales."@es , "La denaturi\u011Do de la proteinoj estas kemia fenomeno kiu reali\u011Das per la \u015Dan\u011Do de la kunnaskita proteina strukturo kun la konsekvenca perdo de la origina funkcio de la molekulo. La denaturi\u011Do estas procezo kiu alportas malaperon de ordo kaj do plii\u011Don de entropio. Post kiam proteino komencis denaturi\u011Di \u011Di fari\u011Das \u0109iam pli sensebla al la disvolviganta fenomeno: tial la denaturi\u011Do estas procezo \u201Ckoopera\u201D. Ne estas endan\u011Derigitaj la peptidaj ligiloj, tial la primara strukturo ne suferas modifojn."@eo , "Onder denatureren wordt in de biochemie het verlies van de ruimtelijke structuur van bepaalde stoffen verstaan, zoals een eiwit of een nucle\u00EFnezuur, waardoor eigenschappen en werking vaak sterk veranderen. Denaturatie vindt plaats onder niet-fysiologische omstandigheden van pH, concentratie en temperatuur."@nl , "\u0627\u0644\u0625\u0641\u0633\u0627\u062F (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Denaturation)\u200F \u0648\u064A\u062F\u0639\u0649 \u0623\u064A\u0636\u0627\u064B \u0627\u0644\u062A\u0645\u0633\u062E \u0648\u0647\u0648 \u0627\u0644\u0639\u0645\u0644\u064A\u0629 \u0627\u0644\u062A\u064A \u064A\u0641\u0642\u062F \u0641\u064A\u0647\u0627 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 \u0623\u0648 \u0627\u0644\u062D\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064A \u0647\u064A\u0643\u0644\u0647 \u0627\u0644\u0631\u0628\u0627\u0639\u064A \u0648\u0627\u0644\u062B\u0644\u0627\u062B\u064A \u0648\u0627\u0644\u062B\u0646\u0627\u0626\u064A \u0627\u0644\u0645\u0648\u062C\u0648\u062F \u0641\u064A \u0627\u0644\u062D\u0627\u0644\u0629 \u0627\u0644\u0637\u0628\u064A\u0639\u064A\u0629\u060C \u0648\u0630\u0644\u0643 \u0628\u062A\u0637\u0628\u064A\u0642 \u062C\u0647\u062F \u062E\u0627\u0631\u062C\u064A \u0639\u0644\u064A\u0647 \u0623\u0648 \u062A\u0639\u0631\u064A\u0636\u0647 \u0644\u0645\u0631\u0643\u0628\u0627\u062A \u0643\u0627\u0644\u062D\u0645\u0648\u0636 \u0648\u0627\u0644\u0623\u0633\u0633 \u0623\u0648 \u0645\u0644\u062D \u0644\u0627\u0639\u0636\u0648\u064A \u0645\u0631\u0643\u0632 \u0623\u0648 \u0645\u0630\u064A\u0628 \u0639\u0636\u0648\u064A (\u0643\u0627\u0644\u0643\u062D\u0648\u0644 \u0648\u0627\u0644\u0643\u0644\u0648\u0631\u0648\u0641\u0648\u0631\u0645) \u0623\u0648 \u0627\u0644\u0625\u0634\u0639\u0627\u0639 \u0623\u0648 \u0627\u0644\u062D\u0631\u0627\u0631\u0629. \u0639\u0646\u062F \u0625\u0641\u0633\u0627\u062F \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 \u0641\u064A \u062E\u0644\u064A\u0629 \u062D\u064A\u0629 \u0641\u0647\u0630\u0627 \u064A\u0624\u062F\u064A \u0625\u0644\u0649 \u062A\u0634\u0648\u064A\u0634 \u0646\u0634\u0627\u0637 \u0627\u0644\u062E\u0644\u064A\u0629 \u0648\u0642\u062F \u064A\u0624\u062F\u064A \u0625\u0644\u0649 \u0645\u0648\u062A\u0647\u0627. \u0648\u064A\u0645\u0643\u0646 \u0644\u0628\u0631\u0648\u062A\u064A\u0646\u0627\u062A \u0627\u0644\u0645\u0641\u0633\u062F\u0629 \u0623\u0646 \u062A\u0628\u062F\u064A \u062A\u063A\u064A\u0631 \u0641\u064A \u0627\u0644\u062E\u0648\u0627\u0635 \u0645\u0646 \u0641\u0642\u062F\u0627\u0646 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u064A\u0629 \u0625\u0644\u0649 \u0627\u0644\u062A\u0643\u062A\u0644 \u0627\u0644\u0645\u0634\u062A\u0631\u0643. \u0644\u0627 \u0639\u0644\u0627\u0642\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0628\u062F\u0623 \u0628\u0627\u0644\u0643\u062D\u0648\u0644 \u0627\u0644\u0645\u063A\u064A\u0631 \u0648\u0647\u064A \u0639\u0645\u0644\u064A\u0629 \u0645\u0632\u062C \u0625\u0636\u0627\u0641\u0627\u062A \u0645\u0639 \u0627\u0644\u0643\u062D\u0648\u0644 \u0644\u062C\u0639\u0644\u0647 \u063A\u064A\u0631 \u0635\u0627\u0644\u062D\u0627\u064B \u0644\u0644\u0627\u0633\u062A\u0647\u0644\u0627\u0643 \u0627\u0644\u0628\u0634\u0631\u064A."@ar , "Biokimikan, desnaturalizazioa proteina eta azido nukleikoen egitura tridimentsionalaren desegiteari deritzo. Desnaturalizazioak molekula horien ezaugarri fisiko-kimikoak nabarmen aldatzen ditu. Proteina baten egitura sekundarioa, tertziarioa eta kuaternarioa elkarrekintza eta lotura molekular ahulei esker mantentzen dira (hidrogeno zubiak, disulfuro loturak: S-S, lotura hidrofoboak, etab). Hainbat eragile fisiko-kimikok (beroa, pHa, gatzen kontzentrazioa...) lotura ahul horiek apurtzen dituzte, proteinaren egitura sekundarioa eta tertziarioa desegiten. Proteinaren egitura primarioari (lotura peptidikoen bidez aminoazidoak elkartzen dituenari) desnaturalizazioak ez dio eragiten, hots, ez ditu lotura peptidikoak suntsitzen."@eu , "Desnatura\u00E7\u00E3o \u00E9 um processo que se d\u00E1 em mol\u00E9culas biol\u00F3gicas, principalmente nas prote\u00EDnas, expostas a condi\u00E7\u00F5es diferentes \u00E0quelas em que foram produzidas, como varia\u00E7\u00F5es de temperatura, mudan\u00E7as de pH, for\u00E7a i\u00F4nica, entre outras. A desnatura\u00E7\u00E3o ocorre quando a prote\u00EDna perde sua estrutura secund\u00E1ria e/ou terci\u00E1ria, ou seja, o arranjo tridimensional da cadeia polipept\u00EDdica \u00E9 rompido, fazendo com que, quase sempre, perca sua atividade biol\u00F3gica caracter\u00EDstica. Algumas prote\u00EDnas desnaturadas, ao serem devolvidas para o seu meio original, podem recuperar a sua configura\u00E7\u00E3o espacial normal, renaturando-se. Entretanto, quando a desnatura\u00E7\u00E3o ocorre por eleva\u00E7\u00F5es extremas de temperatura ou altera\u00E7\u00F5es muito intensas do pH, as modifica\u00E7\u00F5es, geralmente, s\u00E3o irrevers\u00EDveis."@pt . @prefix dbr: . rdfs:seeAlso dbr:Protein_structure . @prefix foaf: . foaf:depiction , , , , , . @prefix dcterms: . @prefix dbc: . dcterms:subject dbc:Nucleic_acids , dbc:Protein_structure ; dbo:wikiPageID 8456 ; dbo:wikiPageRevisionID 1123481340 ; dbo:wikiPageWikiLink dbr:Ethanol , dbr:Hydrogen_bond , dbr:Peptide_bond , dbr:Radiation , dbr:Conformational_change , dbr:Dimethyl_sulfoxide , dbr:Disulfide_bond , dbr:Organic_compound , dbr:Multi-parametric_surface_plasmon_resonance , dbr:Zinc , dbr:Picric_acid , dbr:Trichloroacetic_acid , dbr:Inorganic , dbr:Acetone , dbr:Enzymatic , dbr:Sulfosalicylic_acid , dbr:Enzyme , dbr:DNA_repair , , dbr:DNA_replication , dbr:Ceviche , dbr:Nucleotide , dbr:Secondary_structure , dbr:Side_chain , , dbr:Random_coil , dbr:Northern_blot , dbr:PH , dbr:Non-covalent_interactions , dbr:Biochemistry , dbr:Stiffness , dbr:Dual-polarization_interferometry , dbr:Nitrogenous_base . @prefix ns9: . dbo:wikiPageWikiLink ns9:_A_Structure_for_Deoxyribose_Nucleic_Acid , dbr:Life , dbr:Atmosphere_of_Earth , dbr:Temperature , dbr:Equilibrium_unfolding , dbr:Dipole , dbr:Active_site , dbr:Lithium_perchlorate , dbr:Sodium_dodecyl_sulfate , dbr:Thermostability , dbr:Posttranslational_modification , dbr:Intrinsically_unstructured_proteins , , dbr:Iron , dbr:Copper , dbr:Transition_state , dbr:Membrane_protein , dbr:Denatured_alcohol , dbr:Temperature_gradient_gel_electrophoresis , dbr:Glutaraldehyde , dbr:Native_state , dbr:Rotational_correlation_time , dbr:Circular_dichroism , dbr:Sodium_hydroxide , dbr:Hydrophilic , dbr:Formaldehyde , dbr:Salinity , dbr:Ribosome , dbr:Polymerase_chain_reaction , dbr:Nucleic_acid_double_helix , dbr:Southern_blot , dbr:Van_der_Waals_force , dbr:Gel_electrophoresis_of_nucleic_acids , dbr:Guanidinium_chloride , dbr:Guanidine , dbr:Formamide , dbr:Molarity , dbr:Sedimentation_coefficient , dbr:Sodium_bicarbonate , dbr:Protein_folding , dbr:Homeostasis , dbr:RNA , dbr:Acid , dbr:Oxygen , , dbr:Catalysis , dbr:Protein_aggregation , dbr:Optical_rotation , dbr:Solvent , dbr:International_Union_of_Pure_and_Applied_Chemistry , , dbr:Molecule , dbr:Quartz_crystal_microbalance_with_dissipation_monitoring , dbr:Polypeptide , dbr:Chloroform , dbc:Protein_structure , dbc:Nucleic_acids , dbr:Nucleic_acid_thermodynamics , dbr:Quaternary_structure , dbr:Curdled , dbr:Electronegativity , dbr:Nucleic_acid_sequence , dbr:Urea , , dbr:Amino_acid , dbr:Solubility , dbr:TCEP , , dbr:Physiology , dbr:Hydrophobic , dbr:DNA_Sequencing , , , dbr:Chaotropic_agent , dbr:Alpha_helix , dbr:Beta_sheet , dbr:Tertiary_structure , , dbr:Nucleic_acid , dbr:Heat , , , dbr:Protein , dbr:Sonication , , dbr:Pressure , , dbr:Ovalbumin , dbr:DNA , , , dbr:Nitrogen , dbr:Cross-link , dbr:Phosphate-buffered_saline , dbr:Cysteine , , dbr:Globular_protein , dbr:Dithiothreitol , dbr:Polymerase , dbr:Disulfide_bridge , dbr:Covalent , dbr:Atom , dbr:Sodium_salicylate , dbr:Codon , dbr:Rotational_diffusion , dbr:Acetic_acid , dbr:Propylene_glycol , , dbr:Protein_primary_structure , dbr:Alkalinity ; dbo:wikiPageExternalLink . @prefix ns10: . owl:sameAs ns10:Denaturasyon , , , , , , , . @prefix dbpedia-eu: . owl:sameAs dbpedia-eu:Desnaturalizazio , , , , , . @prefix dbpedia-no: . owl:sameAs dbpedia-no:Denaturering , , , , , . @prefix dbpedia-id: . owl:sameAs dbpedia-id:Denaturasi . @prefix dbpedia-sv: . owl:sameAs dbpedia-sv:Denaturering . @prefix dbpedia-fi: . owl:sameAs dbpedia-fi:Denaturoituminen . @prefix dbpedia-et: . owl:sameAs dbpedia-et:Denaturatsioon . @prefix dbpedia-da: . owl:sameAs dbpedia-da:Denaturering , , , . @prefix ns18: . owl:sameAs ns18:Lluklluy , , . @prefix dbpedia-cs: . owl:sameAs dbpedia-cs:Denaturace , , . @prefix dbpedia-it: . owl:sameAs dbpedia-it:Denaturazione_delle_proteine , , , , , , , , . @prefix dbpedia-sl: . owl:sameAs dbpedia-sl:Denaturacija , . @prefix wikidata: . owl:sameAs wikidata:Q273186 . @prefix dbp: . @prefix dbt: . dbp:wikiPageUsesTemplate dbt:Quote_box , dbt:Ordered_list , dbt:Citation_needed , dbt:Main , dbt:When , dbt:See_also , dbt:Short_description , dbt:Reflist ; dbo:thumbnail ; dbp:align "right"@en ; dbp:quote "Process of partial or total alteration of the native secondary, and/or tertiary, and/or quaternary structures of proteins or nucleic acids resulting in a loss of bioactivity.\n\nNote 1: Modified from the definition given in ref.\n\nNote 2: Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to nonphysiological concentrations of salt, organic solvents, urea, or other chemical agents.\n\nNote 3: An enzyme loses its ability to alter or speed up a chemical reaction when it is denaturized."@en ; dbp:title "IUPAC definition"@en ; dbp:width 30 ; dbo:abstract "Denaturacja bia\u0142ka \u2013 zmiany w II, III- i IV-rz\u0119dowej strukturze bia\u0142ka natywnego (w przeciwie\u0144stwie do wysalania, podczas kt\u00F3rego bia\u0142ka wytr\u0105caj\u0105 si\u0119 bez utraty struktury), kt\u00F3re prowadz\u0105 do utraty aktywno\u015Bci biologicznej lub innej indywidualnej cechy charakterystycznej przy zachowaniu sekwencji aminokwas\u00F3w. Podczas denaturacji niszczone s\u0105 wi\u0105zania wodorowe, a w obecno\u015Bci odczynnik\u00F3w redukuj\u0105cych zerwaniu ulegaj\u0105 mostki dwusiarczkowe. Denaturacja bia\u0142ek mo\u017Ce by\u0107 procesem odwracalnym lub nieodwracalnym; np. denaturacja termiczna bia\u0142ek najcz\u0119\u015Bciej jest nieodwracalna (w przeciwie\u0144stwie do termicznej denaturacji kwas\u00F3w nukleinowych). Stosunkowo niewielkie zmiany pH, w zakresach okre\u015Blonych indywidualnie dla danego bia\u0142ka, prowadz\u0105 do denaturacji odwracalnej (np. b\u0119d\u0105cej efektem utraty rozpuszczalno\u015Bci w punkcie izoelektrycznym), a po przekroczeniu warto\u015Bci krytycznych pH denaturacja nabiera charakteru nieodwracalnego. W przypadku denaturacji odwracalnej, po usuni\u0119ciu czynnika denaturuj\u0105cego bia\u0142ko powraca do aktywnej formy natywnej. Proces ten nosi nazw\u0119 renaturacji i zosta\u0142 zaobserwowany po raz pierwszy dla rybonukleazy przez Christiana Anfinsena w latach 60. XX w. Przej\u015Bcie od natywnego, niskoenergetycznego stanu do formy zdenaturowanej zwi\u0105zane jest ze wzrostem nieuporz\u0105dkowania \u0142a\u0144cucha, kt\u00F3rej to przemianie towarzyszy wzrost entropii. Uporz\u0105dkowanie najbli\u017Cszych cz\u0105steczek wody wzrasta jednak w wyniku hydratacji grup hydrofobowych \u0142a\u0144cuch\u00F3w bocznych, uwolnionych podczas denaturacji. Podczas denaturacji zachodz\u0105 tak\u017Ce zmiany rozpuszczalno\u015Bci i przesuni\u0119cie punktu izoelektrycznego. Rozwini\u0119cie \u0142a\u0144cucha peptydowego mo\u017Ce prowadzi\u0107 do wzrostu lepko\u015Bci, a tak\u017Ce zmian absorpcji w nadfiolecie. Obserwuje si\u0119 r\u00F3wnie\u017C cz\u0119sto procesy agregacji i wytr\u0105cania, co jest zwi\u0105zane ze zmianami stopnia hydratacji i rozpuszczalno\u015Bci bia\u0142ek. Najwa\u017Cniejszymi metodami fizycznymi denaturacji s\u0105: ogrzewanie, silne mieszanie, wytrz\u0105sanie, na\u015Bwietlanie nadfioletem, promieniowaniem rentgenowskim i jonizuj\u0105cym lub dzia\u0142anie ultrad\u017Awi\u0119kami. Denaturacja chemiczna zachodzi pod wp\u0142ywem zwi\u0105zk\u00F3w, kt\u00F3re s\u0105 zdolne do rozerwania wi\u0105za\u0144 wodorowych, na przyk\u0142ad pod wp\u0142ywem roztworu mocznika o st\u0119\u017Ceniu 6\u20138 mol/dm\u00B3 lub chlorku guanidyny o st\u0119\u017Ceniu 4 mol/dm\u00B3, na skutek dzia\u0142ania kwas\u00F3w lub zasad (warto\u015B\u0107 pH poni\u017Cej 3 lub powy\u017Cej 9), soli metali ci\u0119\u017Ckich, a tak\u017Ce 1%-owego roztworu laurylosiarczanu sodu."@pl , "La denaturi\u011Do de la proteinoj estas kemia fenomeno kiu reali\u011Das per la \u015Dan\u011Do de la kunnaskita proteina strukturo kun la konsekvenca perdo de la origina funkcio de la molekulo. La denaturi\u011Do estas procezo kiu alportas malaperon de ordo kaj do plii\u011Don de entropio. Post kiam proteino komencis denaturi\u011Di \u011Di fari\u011Das \u0109iam pli sensebla al la disvolviganta fenomeno: tial la denaturi\u011Do estas procezo \u201Ckoopera\u201D. Ne estas endan\u011Derigitaj la peptidaj ligiloj, tial la primara strukturo ne suferas modifojn. Pro tio la denaturi\u011Do de la proteinoj povas alestigi kaj igi reakciaj iujn funkciajn grupojn pere de kiuj formi\u011Das intermolakulaj kemiaj ligiloj (fortaj a\u016D malfortaj) kiuj povas produkti novan agregadon de diversaj nombraj proteinaj milekuloj."@eo , "Denaturasi atau pengawaaslian adalah sebuah proses di mana protein atau asam nukleat kehilangan struktur tersier dan struktur sekunder dengan penerapan beberapa tekanan eksternal atau senyawa, seperti asam kuat atau basa, garam anorganik terkonsentrasi, sebuah misalnya pelarut organik (cth, alkohol atau kloroform), atau panas. Jika protein dalam sel hidup didenaturasi, ini menyebabkan gangguan terhadap aktivitas sel dan kemungkinan kematian sel. protein didenaturasi dapat menunjukkan berbagai karakteristik, dari hilangnya kelarutan untuk agregasi komunal. Denaturisasi dalam pengertian ini tidak digunakan dalam penyusunan bahan kimia industri alkohol didenaturasi."@in , "\u5909\u6027\uFF08\u3078\u3093\u305B\u3044\u3001\u82F1\u8A9E\uFF1Adenaturation\uFF09\u3068\u306F\u3001\u6027\u8CEA\u304C\u5909\u5316\u3059\u308B\u3053\u3068\u3002\u7279\u306B\u7570\u5E38\u306B\u5909\u5316\u3059\u308B\u5834\u5408\u3092\u6307\u3059\u3053\u3068\u304C\u3042\u308B\u3002\u307E\u305F\u3001\u305D\u306E\u5909\u5316\u3057\u305F\u6027\u8CEA\u305D\u306E\u3082\u306E\u3092\u6307\u3059\u3002"@ja , "\uBCC0\uC131(\u8B8A\u6027, \uC601\uC5B4: denaturation)\uC740 \uB2E8\uBC31\uC9C8\uC774\uB098 \uD575\uC0B0\uC774 \uAC15\uD55C \uC0B0\uC774\uB098 \uC5FC\uAE30, \uC5F4, \uB18D\uCD95\uB41C \uBB34\uAE30\uC5FC, \uC720\uAE30\uC6A9\uC81C(\uC54C\uCF54\uC62C \uB610\uB294 \uD074\uB85C\uB85C\uD3EC\uB984), \uBC29\uC0AC\uC120\uACFC \uAC19\uC740 \uC77C\uBD80 \uC678\uBD80 \uC790\uADF9\uC774\uB098 \uD654\uD569\uBB3C\uC744 \uC801\uC6A9\uD568\uC73C\uB85C\uC368 \uBCF8\uB798\uC758 \uC0C1\uD0DC\uC5D0 \uC874\uC7AC\uD558\uB294 2\uCC28 \uAD6C\uC870, 3\uCC28 \uAD6C\uC870, 4\uCC28 \uAD6C\uC870\uB97C \uC0C1\uC2E4\uD558\uB294 \uACFC\uC815\uC774\uB2E4. \uC0B4\uC544\uC788\uB294 \uC138\uD3EC\uC758 \uB2E8\uBC31\uC9C8\uC774 \uBCC0\uC131\uB418\uBA74 \uC138\uD3EC \uD65C\uC131\uC758 \uD30C\uAD34 \uBC0F \uC138\uD3EC \uC790\uC0B4\uC744 \uCD08\uB798\uD55C\uB2E4. \uB2E8\uBC31\uC9C8 \uBCC0\uC131\uC740 \uC138\uD3EC \uC790\uC0B4\uC758 \uACB0\uACFC\uC774\uB2E4. \uBCC0\uC131 \uB2E8\uBC31\uC9C8\uC740 \uC21C\uC751\uC801 \uBCC0\uD654 \uBC0F \uC6A9\uD574\uB825 \uC190\uC2E4\uC5D0\uC11C\uBD80\uD130 \uC18C\uC218\uC131 \uADF8\uB8F9\uC758 \uB178\uCD9C\uC5D0 \uC758\uD55C \uC9D1\uACC4\uC5D0 \uC774\uB974\uAE30\uAE4C\uC9C0 \uAD11\uBC94\uC704\uD55C \uD2B9\uC131\uC744 \uB098\uD0C0\uB0BC \uC218 \uC788\uB2E4. \uBCC0\uC131 \uB2E8\uBC31\uC9C8\uC740 3\uCC28\uC6D0 \uAD6C\uC870\uB97C \uC783\uAE30 \uB54C\uBB38\uC5D0 \uAE30\uB2A5\uC744 \uD560 \uC218 \uC5C6\uB2E4. \uB2E8\uBC31\uC9C8 \uC811\uD798\uC740 \uAD6C\uC0C1 \uB2E8\uBC31\uC9C8\uC774\uB098 \uB9C9 \uB2E8\uBC31\uC9C8\uC774 \uC81C\uB300\uB85C \uC791\uB3D9\uD560 \uC218 \uC788\uAC8C \uD558\uB294 \uC5F4\uC1E0\uC640 \uAC19\uC740 \uACFC\uC815\uC774\uB2E4. \uB2E8\uBC31\uC9C8\uC774 \uC791\uB3D9\uD558\uB824\uBA74 \uC62C\uBC14\uB978 \uBAA8\uC591\uC73C\uB85C \uC811\uD600\uC57C \uD55C\uB2E4. \uADF8\uB7EC\uB098 \uC811\uD798\uC5D0\uC11C \uD070 \uC5ED\uD560\uC744 \uD558\uB294 \uC218\uC18C \uACB0\uD569\uC740 \uC57D\uD574\uC11C \uC5F4, \uC0B0\uB3C4, \uB2E4\uC591\uD55C \uC5FC \uB18D\uB3C4 \uBC0F \uB2E8\uBC31\uC9C8\uC744 \uBCC0\uC131\uC2DC\uD0AC \uC218 \uC788\uB294 \uB2E4\uB978 \uC790\uADF9 \uC694\uC778\uC5D0 \uC758\uD574 \uC27D\uAC8C \uC601\uD5A5\uC744 \uBC1B\uB294\uB2E4. \uC774 \uAC1C\uB150\uC740 \uBCC0\uC131 \uC54C\uCF54\uC62C\uACFC \uAD00\uB828\uC774 \uC5C6\uC73C\uBA70, \uC774\uB294 \uC54C\uCF54\uC62C\uC774 \uC0AC\uB78C\uC758 \uC18C\uBE44\uC5D0 \uBD80\uC801\uD569\uD558\uB3C4\uB85D \uCCA8\uAC00\uC81C\uC640 \uD63C\uD569\uB41C \uC54C\uCF54\uC62C\uC774\uB2E4."@ko , "Denaturierung bezeichnet eine strukturelle Ver\u00E4nderung von Biomolek\u00FClen wie Proteinen (Eiwei\u00DFe) oder Desoxyribonukleins\u00E4ure (DNS), die in den meisten F\u00E4llen mit einem Verlust der biologischen Funktion dieser Molek\u00FCle verbunden ist, obgleich deren Prim\u00E4rstruktur unver\u00E4ndert bleibt. Eine Denaturierung kann auf physikalische oder auf chemische Einfl\u00FCsse zur\u00FCckzuf\u00FChren sein."@de , "En bioqu\u00EDmica, la desnaturalitzaci\u00F3 \u00E9s un canvi estructural de les prote\u00EFnes o \u00E0cids nucleics, on perden la seva estructura terci\u00E0ria i estructura secund\u00E0ria, per haver aplicat una for\u00E7a externa o compost qu\u00EDmic, com pot ser un \u00E0cid fort o una base qu\u00EDmica, una sal inorg\u00E0nica concentrada o un solvent (per exemple alcohol o cloroform) o la calor. Si les prote\u00EFnes en un organisme viu es desnaturalitzen aix\u00F2 resulta en una interrupci\u00F3 de l'activitat cel\u00B7lular i possiblement la mort cel\u00B7lular. Les prote\u00EFnes desnaturalitzades poden mostrar una ampli rang de caracter\u00EDstiques, des de la p\u00E8rdua de la solubilitat a l'agregaci\u00F3. El concepte de desnaturalitzaci\u00F3 bioqu\u00EDmica no est\u00E0 relacionat amb la desnaturalitzaci\u00F3 intencionada de productes com en el cas d'alcohol desnaturalitzat, oli desnaturalitzat en els quals els productes es mesclen amb additius per a fer-los no aptes pel consum hum\u00E0 i dedicar-los normalment a processos industrials."@ca , "Onder denatureren wordt in de biochemie het verlies van de ruimtelijke structuur van bepaalde stoffen verstaan, zoals een eiwit of een nucle\u00EFnezuur, waardoor eigenschappen en werking vaak sterk veranderen. Denaturatie vindt plaats onder niet-fysiologische omstandigheden van pH, concentratie en temperatuur."@nl , "\u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0438\u044F \u0431\u0435\u043B\u043A\u043E\u0432 (\u043B\u0430\u0442. denaturatus \u2014 \u043B\u0438\u0448\u0451\u043D\u043D\u044B\u0439 \u043F\u0440\u0438\u0440\u043E\u0434\u043D\u044B\u0445 \u0441\u0432\u043E\u0439\u0441\u0442\u0432; \u043E\u0442 de- \u2014 \u043F\u0440\u0438\u0441\u0442\u0430\u0432\u043A\u0430, \u043E\u0437\u043D\u0430\u0447\u0430\u044E\u0449\u0430\u044F \u043E\u0442\u0434\u0435\u043B\u0435\u043D\u0438\u0435, \u0443\u0434\u0430\u043B\u0435\u043D\u0438\u0435 + natura \u2014 \u043F\u0440\u0438\u0440\u043E\u0434\u0430, \u0435\u0441\u0442\u0435\u0441\u0442\u0432\u043E) \u2014 \u0438\u0437\u043C\u0435\u043D\u0435\u043D\u0438\u0435 \u043D\u0430\u0442\u0438\u0432\u043D\u043E\u0439 \u043A\u043E\u043D\u0444\u043E\u0440\u043C\u0430\u0446\u0438\u0438 \u0431\u0435\u043B\u043A\u043E\u0432\u043E\u0439 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044B \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u0440\u0430\u0437\u043B\u0438\u0447\u043D\u044B\u0445 \u0434\u0435\u0441\u0442\u0430\u0431\u0438\u043B\u0438\u0437\u0438\u0440\u0443\u044E\u0449\u0438\u0445 \u0444\u0430\u043A\u0442\u043E\u0440\u043E\u0432. \u0410\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442\u043D\u0430\u044F \u043F\u043E\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u0442\u0435\u043B\u044C\u043D\u043E\u0441\u0442\u044C \u0431\u0435\u043B\u043A\u0430 \u043D\u0435 \u0438\u0437\u043C\u0435\u043D\u044F\u0435\u0442\u0441\u044F. \u041F\u0440\u0438\u0432\u043E\u0434\u0438\u0442 \u043A \u043F\u043E\u0442\u0435\u0440\u0435 \u0431\u0435\u043B\u043A\u0430\u043C\u0438 \u0438\u0445 \u0435\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043D\u043D\u044B\u0445 \u0441\u0432\u043E\u0439\u0441\u0442\u0432 (\u0440\u0430\u0441\u0442\u0432\u043E\u0440\u0438\u043C\u043E\u0441\u0442\u0438, \u0433\u0438\u0434\u0440\u043E\u0444\u0438\u043B\u044C\u043D\u043E\u0441\u0442\u0438 \u0438 \u0434\u0440.). \u041F\u0440\u043E\u0446\u0435\u0441\u0441 \u0434\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0438\u0438 \u043E\u0442\u0434\u0435\u043B\u044C\u043D\u043E\u0439 \u0431\u0435\u043B\u043A\u043E\u0432\u043E\u0439 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044B, \u043F\u0440\u0438\u0432\u043E\u0434\u044F\u0449\u0438\u0439 \u043A \u0440\u0430\u0441\u043F\u0430\u0434\u0443 \u0435\u0451 \u00AB\u0436\u0451\u0441\u0442\u043A\u043E\u0439\u00BB \u0442\u0440\u0451\u0445\u043C\u0435\u0440\u043D\u043E\u0439 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u044B, \u0438\u043D\u043E\u0433\u0434\u0430 \u043D\u0430\u0437\u044B\u0432\u0430\u044E\u0442 \u043F\u043B\u0430\u0432\u043B\u0435\u043D\u0438\u0435\u043C \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044B."@ru , "La denaturazione delle proteine \u00E8 un fenomeno chimico che consiste nel cambiamento della struttura proteica nativa, con conseguente perdita della funzione originaria della molecola. La denaturazione \u00E8 un processo che porta alla perdita di ordine e quindi a un aumento di entropia. Dopo che una proteina ha cominciato a denaturarsi diviene sempre pi\u00F9 sensibile al processo, quindi la denaturazione \u00E8 un processo cooperativo. Non vengono compromessi i legami peptidici. La struttura primaria non viene modificata. In seguito alla denaturazione le proteine possono esporre e rendere reattivi alcuni gruppi funzionali tramite i quali formare dei legami intramolecolari (deboli o forti) che possono causare l'aggregazione di pi\u00F9 molecole proteiche."@it , "\u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0301\u0446\u0456\u044F \u2014 \u043F\u043E\u0440\u0443\u0448\u0435\u043D\u043D\u044F \u0432\u0438\u0441\u043E\u043A\u043E\u0440\u0456\u0432\u043D\u0435\u0432\u043E\u0457 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0438 \u043C\u0430\u043A\u0440\u043E\u043C\u043E\u043B\u0435\u043A\u0443\u043B (\u0437\u0430\u0437\u0432\u0438\u0447\u0430\u0439 \u0431\u0456\u043B\u043A\u0456\u0432 \u0430\u0431\u043E \u043D\u0443\u043A\u043B\u0435\u0457\u043D\u043E\u0432\u0438\u0445 \u043A\u0438\u0441\u043B\u043E\u0442) \u0443 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0456 \u0435\u043A\u0441\u0442\u0440\u0435\u043C\u0430\u043B\u044C\u043D\u0438\u0445 \u0443\u043C\u043E\u0432 \u043D\u0430\u0432\u043A\u043E\u043B\u0438\u0448\u043D\u044C\u043E\u0433\u043E \u0441\u0435\u0440\u0435\u0434\u043E\u0432\u0438\u0449\u0430, \u043D\u0430\u043F\u0440\u0438\u043A\u043B\u0430\u0434, \u043E\u0431\u0440\u043E\u0431\u043A\u0438 \u043A\u0438\u0441\u043B\u043E\u0442\u0430\u043C\u0438 \u0430\u0431\u043E \u043E\u0441\u043D\u043E\u0432\u0430\u043C\u0438, \u0432\u0438\u0441\u043E\u043A\u0438\u043C\u0438 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044F\u043C\u0438 \u043D\u0435\u043E\u0440\u0433\u0430\u043D\u0456\u0447\u043D\u0438\u0445 \u0441\u043E\u043B\u0435\u0439 \u0430\u0431\u043E \u043E\u0440\u0433\u0430\u043D\u0456\u0447\u043D\u0438\u0445 \u0440\u043E\u0437\u0447\u0438\u043D\u043D\u0438\u043A\u0456\u0432 (\u0441\u043F\u0438\u0440\u0442, \u0445\u043B\u043E\u0440\u043E\u0444\u043E\u0440\u043C), \u043D\u0430\u0433\u0440\u0456\u0432\u0430\u043D\u043D\u044F. \u0423 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0456 \u043C\u0430\u043A\u0440\u043E\u043C\u043E\u043B\u0435\u043A\u0443\u043B\u0430 \u0432\u0442\u0440\u0430\u0447\u0430\u0454 \u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u0442\u0430\u043D \u0442\u0430 \u043D\u0435\u043E\u0431\u0445\u0456\u0434\u043D\u0456 \u0432\u043B\u0430\u0441\u0442\u0438\u0432\u043E\u0441\u0442\u0456 \u0434\u043B\u044F \u0444\u0443\u043D\u043A\u0446\u0456\u043E\u043D\u0443\u0432\u0430\u043D\u043D\u044F \u0432 \u043A\u043B\u0456\u0442\u0438\u043D\u0456. \u0414\u0435\u043D\u0430\u0442\u0443\u0440\u043E\u0432\u0430\u043D\u0456 \u0431\u0456\u043B\u043A\u0438 \u043F\u0440\u043E\u044F\u0432\u043B\u044F\u044E\u0442\u044C \u0448\u0438\u0440\u043E\u043A\u0438\u0439 \u0440\u044F\u0434 \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043A, \u0432\u0456\u0434 \u0432\u0442\u0440\u0430\u0442\u0438 \u0440\u043E\u0437\u0447\u0438\u043D\u043D\u043E\u0441\u0442\u0456 \u0434\u043E \u0430\u0433\u0440\u0435\u0433\u0430\u0446\u0456\u0457. \u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0456\u044F \u0431\u0456\u043B\u043A\u0430 \u2014 \u0446\u0435 \u0442\u0438\u043C\u0447\u0430\u0441\u043E\u0432\u0435 \u0430\u0431\u043E \u043F\u043E\u0441\u0442\u0456\u0439\u043D\u0435 \u043F\u043E\u0440\u0443\u0448\u0435\u043D\u043D\u044F \u0447\u0435\u0442\u0432\u0435\u0440\u0442\u0438\u043D\u043D\u043E\u0457, \u0442\u0440\u0435\u0442\u0438\u043D\u043D\u043E\u0457 \u0456 \u0432\u0442\u043E\u0440\u0438\u043D\u043D\u043E\u0457 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0438 \u0431\u0456\u043B\u043A\u0430. \u0412\u043E\u043D\u043E \u043C\u043E\u0436\u0435 \u0431\u0443\u0442\u0438 \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u043D\u0435 \u043D\u0430\u0433\u0440\u0456\u0432\u0430\u043D\u043D\u044F\u043C, \u0434\u0456\u0454\u044E \u0440\u0430\u0434\u0456\u0430\u0446\u0456\u0457, \u0441\u0442\u0440\u0443\u0448\u0443\u0432\u0430\u043D\u043D\u044F\u043C \u0442\u043E\u0449\u043E. \u0414\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0456\u044F \u0431\u0456\u043B\u043A\u0430 \u0432\u0456\u0434\u0431\u0443\u0432\u0430\u0454\u0442\u044C\u0441\u044F \u043F\u0440\u0438 \u0432\u0430\u0440\u0456\u043D\u043D\u0456 \u044F\u0454\u0446\u044C, \u043F\u0440\u0438\u0433\u043E\u0442\u0443\u0432\u0430\u043D\u043D\u0456 \u0457\u0436\u0456 \u0442\u043E\u0449\u043E. \u0420\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0456\u044F \u2014 \u0446\u0435 \u043F\u0440\u043E\u0446\u0435\u0441, \u043E\u0431\u043E\u0440\u043E\u0442\u043D\u0438\u0439 \u0434\u0435\u043D\u0430\u0442\u0443\u0440\u0430\u0446\u0456\u0457, \u043F\u0440\u0438 \u044F\u043A\u043E\u043C\u0443 \u0431\u0456\u043B\u043A\u0438 \u043F\u043E\u0432\u0435\u0440\u0442\u0430\u044E\u0442\u044C \u0441\u0432\u043E\u044E \u0447\u0435\u0442\u0432\u0435\u0440\u0442\u0438\u043D\u043D\u0443, \u0442\u0440\u0435\u0442\u0438\u043D\u043D\u0443 \u0456 \u0432\u0442\u043E\u0440\u0438\u043D\u043D\u0443 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0443."@uk , "In biochemistry, denaturation is a process in which proteins or nucleic acids lose the quaternary structure, tertiary structure, and secondary structure which is present in their native state, by application of some external stress or compound such as a strong acid or base, a concentrated inorganic salt, an organic solvent (e.g., alcohol or chloroform), agitation and radiation or heat. If proteins in a living cell are denatured, this results in disruption of cell activity and possibly cell death. Protein denaturation is also a consequence of cell death. Denatured proteins can exhibit a wide range of characteristics, from conformational change and loss of solubility to aggregation due to the exposure of hydrophobic groups. The loss of solubility as a result of denaturation is called coagulation. Denatured proteins lose their 3D structure and therefore cannot function. Protein folding is key to whether a globular or membrane protein can do its job correctly; it must be folded into the right shape to function. However, hydrogen bonds, which play a big part in folding, are rather weak and thus easily affected by heat, acidity, varying salt concentrations, and other stressors which can denature the protein. This is one reason why homeostasis is physiologically necessary in many life forms. This concept is unrelated to denatured alcohol, which is alcohol that has been mixed with additives to make it unsuitable for human consumption."@en , "Biokimikan, desnaturalizazioa proteina eta azido nukleikoen egitura tridimentsionalaren desegiteari deritzo. Desnaturalizazioak molekula horien ezaugarri fisiko-kimikoak nabarmen aldatzen ditu. Proteina baten egitura sekundarioa, tertziarioa eta kuaternarioa elkarrekintza eta lotura molekular ahulei esker mantentzen dira (hidrogeno zubiak, disulfuro loturak: S-S, lotura hidrofoboak, etab). Hainbat eragile fisiko-kimikok (beroa, pHa, gatzen kontzentrazioa...) lotura ahul horiek apurtzen dituzte, proteinaren egitura sekundarioa eta tertziarioa desegiten. Proteinaren egitura primarioari (lotura peptidikoen bidez aminoazidoak elkartzen dituenari) desnaturalizazioak ez dio eragiten, hots, ez ditu lotura peptidikoak suntsitzen. Proteinak tolesten direnean egitura tridimentsional konplexuak eratzen dituzte. Desnaturalizazioak tolestura horiek deusestatzen ditu, proteinaren jatorrizko konfigurazioa aldatuz. Horren ondorioz proteinek haien funtzio biologikoa galtzen dute (entzimek, esaterako, ez dute jarduera katalitikorik). Kasu gehienetan desnaturalizazioa itzuliezina da. Zenbait kasutan, baina, desnaturalizazio prozesua arina bada leheneratu daiteke, eta proteina berriro tolesten da (birnaturalizazioa); jatorrizko konformazioa berreskuratzen du, eta baita bere funtzio biologikoa ere. Desnaturalizazioak, askotan, proteinen disolbagarritasuna aldatzen du: haien jatorrizko arkitektura molekularra galtzerakoan proteinek sarri hauspeatzen dute. Azido nukleikoei dagokionez, desnaturalizazioak helize bikoitza mantentzen duten hidrogeno zubien suntsiketa eragiten du, ADNaren molekula deseginez. Tenperatura da eragile desnaturalizatzaile nagusia. Proteina eta azido nukleiko gehienak desnaturalizatzen dira tenperatura altuetan (>60 \u00B0C-etan)"@eu , "Desnatura\u00E7\u00E3o \u00E9 um processo que se d\u00E1 em mol\u00E9culas biol\u00F3gicas, principalmente nas prote\u00EDnas, expostas a condi\u00E7\u00F5es diferentes \u00E0quelas em que foram produzidas, como varia\u00E7\u00F5es de temperatura, mudan\u00E7as de pH, for\u00E7a i\u00F4nica, entre outras. A desnatura\u00E7\u00E3o ocorre quando a prote\u00EDna perde sua estrutura secund\u00E1ria e/ou terci\u00E1ria, ou seja, o arranjo tridimensional da cadeia polipept\u00EDdica \u00E9 rompido, fazendo com que, quase sempre, perca sua atividade biol\u00F3gica caracter\u00EDstica. Algumas prote\u00EDnas desnaturadas, ao serem devolvidas para o seu meio original, podem recuperar a sua configura\u00E7\u00E3o espacial normal, renaturando-se. Entretanto, quando a desnatura\u00E7\u00E3o ocorre por eleva\u00E7\u00F5es extremas de temperatura ou altera\u00E7\u00F5es muito intensas do pH, as modifica\u00E7\u00F5es, geralmente, s\u00E3o irrevers\u00EDveis. Quando as prote\u00EDnas sofrem desnatura\u00E7\u00E3o n\u00E3o ocorre rompimento de liga\u00E7\u00F5es covalentes do esqueleto da cadeia polipept\u00EDdica, preservando a seq\u00FC\u00EAncia de amino\u00E1cidos caracter\u00EDstica da prote\u00EDna (estrutura prim\u00E1ria). Os fatores que causam a desnatura\u00E7\u00E3o, s\u00E3o: \n* Aumento de temperatura (cada prote\u00EDna suporta certa temperatura m\u00E1xima, se esse limite \u00E9 ultrapassado ela desnatura); \n* Extremos de pH; \n* Solventes org\u00E2nicos misc\u00EDveis com a \u00E1gua (etanol e acetona); \n* Solutos (ureia); \n* Exposi\u00E7\u00E3o da prote\u00EDna a detergentes; \n* Agita\u00E7\u00E3o vigorosa da solu\u00E7\u00E3o proteica at\u00E9 forma\u00E7\u00E3o abundante de espuma. Dois exemplos simples de desnatura\u00E7\u00E3o ocorrem: \n* Ao pingar gotas de lim\u00E3o no leite, o pH \u00E9 alterado, causando a desnatura\u00E7\u00E3o das prote\u00EDnas, que se precipitam na forma de coalho (Cf. queijo). \n* Ao cozinhar um ovo, o calor modifica irreversivelmente a clara, que \u00E9 formada pela prote\u00EDna albumina e \u00E1gua. A desnatura\u00E7\u00E3o tamb\u00E9m atinge enzimas, que realizam fun\u00E7\u00F5es vitais no corpo. Por isso que m\u00E9dicos preocupam-se em baixar a febre, primeiro, para ent\u00E3o descobrir sua causa, pois a alta temperatura pode destruir enzimas de fun\u00E7\u00F5es vitais, como as enzimas que auxiliam no processo respirat\u00F3rio (transporte de subst\u00E2ncia via hemoglobina)."@pt , "\u53D8\u6027\uFF08\u82F1\u8A9E\uFF1ADenaturation\uFF09\u5728\u751F\u7269\u5316\u5B66\u4E2D\u662F\u6307\u86CB\u767D\u8D28\u6216\u6838\u9178\u53D7\u5230\u67D0\u4E9B\u7406\u5316\u56E0\u7D20\u7684\u4F5C\u7528\uFF0C\u5176\u9AD8\u7EA7\u7ED3\u6784\u53D1\u751F\u7834\u574F\u4ECE\u800C\u4E27\u5931\u751F\u7269\u6D3B\u6027\u7684\u73B0\u8C61\u3002"@zh , "En biochimie, la d\u00E9naturation est le processus par lequel une macromol\u00E9cule biologique, acide nucl\u00E9ique ou prot\u00E9ine, perd sa conformation tridimensionnelle normale : les prot\u00E9ines perdent leur repliement et se d\u00E9plient, les deux brins appari\u00E9s des duplex d'acides nucl\u00E9iques se s\u00E9parent. Cette conformation tridimensionnelle est le plus souvent n\u00E9cessaire pour que les macromol\u00E9cules biologiques puissent remplir leur fonction et donc la d\u00E9naturation inactive en g\u00E9n\u00E9ral ces macromol\u00E9cules biologiques."@fr , "\u03A4\u03CC\u03C3\u03BF \u03C3\u03C4\u03B7 \u039C\u03BF\u03C1\u03B9\u03B1\u03BA\u03AE \u0392\u03B9\u03BF\u03BB\u03BF\u03B3\u03AF\u03B1 \u03CC\u03C3\u03BF \u03BA\u03B1\u03B9 \u03C3\u03C4\u03B7 \u0392\u03B9\u03BF\u03C7\u03B7\u03BC\u03B5\u03AF\u03B1 \u03BC\u03B5 \u03C4\u03BF\u03BD \u03CC\u03C1\u03BF \u03BC\u03B5\u03C4\u03BF\u03C5\u03C3\u03AF\u03C9\u03C3\u03B7, \u03C7\u03B1\u03C1\u03B1\u03BA\u03C4\u03B7\u03C1\u03AF\u03B6\u03B5\u03C4\u03B1\u03B9 \u03C4\u03BF \u03C6\u03B1\u03B9\u03BD\u03CC\u03BC\u03B5\u03BD\u03BF \u03C4\u03B7\u03C2 \u03B4\u03B9\u03AC\u03C3\u03C0\u03B1\u03C3\u03B7\u03C2 \u03C4\u03C9\u03BD \u03B4\u03B5\u03C3\u03BC\u03CE\u03BD, \u03C3\u03C4\u03B7 \u03B4\u03B5\u03C5\u03C4\u03B5\u03C1\u03BF\u03C4\u03B1\u03B3\u03AE, 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\u03B4\u03B9\u03B1\u03B4\u03B9\u03BA\u03B1\u03C3\u03AF\u03B1 \u03C0\u03BF\u03C5 \u03BC\u03C0\u03BF\u03C1\u03B5\u03AF \u03BD\u03B1 \u03C0\u03C1\u03BF\u03BA\u03BB\u03B7\u03B8\u03B5\u03AF \u03B1\u03C0\u03CC \u03B4\u03B9\u03AC\u03C6\u03BF\u03C1\u03BF\u03C5\u03C2 \u03C0\u03B1\u03C1\u03AC\u03B3\u03BF\u03BD\u03C4\u03B5\u03C2 \u03CC\u03C0\u03C9\u03C2 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03B7 \u03C5\u03C0\u03B5\u03C1\u03B2\u03BF\u03BB\u03B9\u03BA\u03AE \u03B8\u03B5\u03C1\u03BC\u03CC\u03C4\u03B7\u03C4\u03B1, \u03C4\u03B1 \u03B9\u03C3\u03C7\u03C5\u03C1\u03AC \u03BF\u03BE\u03AD\u03B1 \u03AE \u03B1\u03BB\u03BA\u03AC\u03BB\u03B9\u03B1, \u03BF\u03B9 \u03BF\u03C1\u03B3\u03B1\u03BD\u03B9\u03BA\u03BF\u03AF \u03B4\u03B9\u03B1\u03BB\u03CD\u03C4\u03B5\u03C2, \u03BA\u03B1\u03B8\u03CE\u03C2 \u03B1\u03BA\u03CC\u03BC\u03B7 \u03BA\u03B1\u03B9 \u03BF\u03B9 \u03C5\u03C0\u03B5\u03C1\u03B7\u03C7\u03B7\u03C4\u03B9\u03BA\u03AD\u03C2 \u03B4\u03BF\u03BD\u03AE\u03C3\u03B5\u03B9\u03C2. \u03A3\u03B5 \u03BC\u03B5\u03C1\u03B9\u03BA\u03AD\u03C2 \u03BC\u03AC\u03BB\u03B9\u03C3\u03C4\u03B1 \u03C0\u03B5\u03C1\u03B9\u03C0\u03C4\u03CE\u03C3\u03B5\u03B9\u03C2 \u03B7 \u03BC\u03B5\u03C4\u03BF\u03C5\u03C3\u03AF\u03C9\u03C3\u03B7 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03BC\u03B7 \u03B1\u03BD\u03B1\u03C3\u03C4\u03C1\u03AD\u03C8\u03B9\u03BC\u03B7, \u03CC\u03C0\u03C9\u03C2 \u03B3\u03B9\u03B1 \u03C0\u03B1\u03C1\u03AC\u03B4\u03B5\u03B9\u03B3\u03BC\u03B1 \u03B7 \u03B8\u03AD\u03C1\u03BC\u03B1\u03BD\u03C3\u03B7 \u03C4\u03BF\u03C5 \u03BB\u03B5\u03C5\u03BA\u03CE\u03BC\u03B1\u03C4\u03BF\u03C2 \u03C4\u03BF\u03C5 \u03B1\u03C5\u03B3\u03BF\u03CD \u03C0\u03BF\u03C5 \u03B4\u03AF\u03BD\u03B5\u03B9 \u03C3\u03C5\u03BC\u03C0\u03B1\u03B3\u03AD\u03C2 \u03B1\u03C3\u03C0\u03C1\u03AC\u03B4\u03B9. \u038C\u03C4\u03B1\u03BD \u03C3\u03C5\u03BD\u03C4\u03B5\u03BB\u03B5\u03AF\u03C4\u03B1\u03B9 \u03BC\u03B5\u03C4\u03BF\u03C5\u03C3\u03AF\u03C9\u03C3\u03B7 \u03C3\u03C4\u03B1 \u03AD\u03BD\u03B6\u03C5\u03BC\u03B1, 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\u03C4\u03BF\u03C5\u03C2. \u0397 \u03B8\u03B5\u03C1\u03BC\u03BF\u03BA\u03C1\u03B1\u03C3\u03AF\u03B1 \u03C4\u03BF\u03C5 \u03BC\u03AD\u03C3\u03BF\u03C5 \u03C3\u03B7\u03BC\u03B5\u03AF\u03BF\u03C5 \u03C4\u03B7\u03C2 \u03BA\u03B1\u03BC\u03C0\u03CD\u03BB\u03B7\u03C2 \u03B8\u03B5\u03C1\u03BC\u03CC\u03C4\u03B7\u03C4\u03B1\u03C2 \u03C4\u03B7\u03C2 \u03BC\u03B5\u03C4\u03BF\u03C5\u03C3\u03AF\u03C9\u03C3\u03B7\u03C2 \u03B1\u03BD\u03B1\u03C6\u03AD\u03C1\u03B5\u03C4\u03B1\u03B9 \u03BA\u03B1\u03B9 \u03C9\u03C2 \"\u03C3\u03B7\u03BC\u03B5\u03AF\u03BF \u03C4\u03AE\u03BE\u03B7\u03C2\" (\u03BD\u03B1 \u03BC\u03B7 \u03C3\u03C5\u03B3\u03C7\u03AD\u03B5\u03C4\u03B1\u03B9 \u03BC\u03B5 \u03C4\u03B7 \u03B8\u03B5\u03C1\u03BC\u03BF\u03BA\u03C1\u03B1\u03C3\u03AF\u03B1 \u03B1\u03BB\u03BB\u03B1\u03B3\u03AE\u03C2 \u03C6\u03AC\u03C3\u03B7\u03C2 \u03C4\u03C9\u03BD \u03C5\u03BB\u03B9\u03BA\u03CE\u03BD)."@el , "En bioqu\u00EDmica, la desnaturalizaci\u00F3n es un cambio estructural de las prote\u00EDnas o \u00E1cidos nucleicos, donde pierden su estructura nativa, y de esta forma su \u00F3ptimo funcionamiento y a veces tambi\u00E9n cambian sus propiedades f\u00EDsico-qu\u00EDmicas-estructurales."@es , "\u0627\u0644\u0625\u0641\u0633\u0627\u062F (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Denaturation)\u200F \u0648\u064A\u062F\u0639\u0649 \u0623\u064A\u0636\u0627\u064B \u0627\u0644\u062A\u0645\u0633\u062E \u0648\u0647\u0648 \u0627\u0644\u0639\u0645\u0644\u064A\u0629 \u0627\u0644\u062A\u064A \u064A\u0641\u0642\u062F \u0641\u064A\u0647\u0627 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 \u0623\u0648 \u0627\u0644\u062D\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064A \u0647\u064A\u0643\u0644\u0647 \u0627\u0644\u0631\u0628\u0627\u0639\u064A \u0648\u0627\u0644\u062B\u0644\u0627\u062B\u064A \u0648\u0627\u0644\u062B\u0646\u0627\u0626\u064A \u0627\u0644\u0645\u0648\u062C\u0648\u062F \u0641\u064A \u0627\u0644\u062D\u0627\u0644\u0629 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\u062A\u0634\u0648\u064A\u0634 \u0646\u0634\u0627\u0637 \u0627\u0644\u062E\u0644\u064A\u0629 \u0648\u0642\u062F \u064A\u0624\u062F\u064A \u0625\u0644\u0649 \u0645\u0648\u062A\u0647\u0627. \u0648\u064A\u0645\u0643\u0646 \u0644\u0628\u0631\u0648\u062A\u064A\u0646\u0627\u062A \u0627\u0644\u0645\u0641\u0633\u062F\u0629 \u0623\u0646 \u062A\u0628\u062F\u064A \u062A\u063A\u064A\u0631 \u0641\u064A \u0627\u0644\u062E\u0648\u0627\u0635 \u0645\u0646 \u0641\u0642\u062F\u0627\u0646 \u0627\u0644\u0630\u0648\u0628\u0627\u0646\u064A\u0629 \u0625\u0644\u0649 \u0627\u0644\u062A\u0643\u062A\u0644 \u0627\u0644\u0645\u0634\u062A\u0631\u0643. \u0644\u0627 \u0639\u0644\u0627\u0642\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0628\u062F\u0623 \u0628\u0627\u0644\u0643\u062D\u0648\u0644 \u0627\u0644\u0645\u063A\u064A\u0631 \u0648\u0647\u064A \u0639\u0645\u0644\u064A\u0629 \u0645\u0632\u062C \u0625\u0636\u0627\u0641\u0627\u062A \u0645\u0639 \u0627\u0644\u0643\u062D\u0648\u0644 \u0644\u062C\u0639\u0644\u0647 \u063A\u064A\u0631 \u0635\u0627\u0644\u062D\u0627\u064B \u0644\u0644\u0627\u0633\u062A\u0647\u0644\u0627\u0643 \u0627\u0644\u0628\u0634\u0631\u064A."@ar , "Denaturering, av latin de och natura, 'g\u00F6ra onaturlig', inneb\u00E4r rent generellt att ett \u00E4mnes beskaffenhet f\u00F6r\u00E4ndras s\u00E5 att det inte kan anv\u00E4ndas f\u00F6r ett specifikt \u00E4ndam\u00E5l. N\u00E4r ett \u00E4mne denatureras f\u00F6r\u00E4ndras strukturen eller egenskaperna i \u00E4mnet. Vid kemisk denaturering, vilket \u00E4r den vanligaste formen av denaturering, f\u00F6r\u00E4ndras ett proteins egenskaper samt f\u00F6rlorar proteinet sin biologiska funktion.. En annan anv\u00E4ndning av denaturering kan vara att denaturera tex handsprit med hj\u00E4lp av denatureringsmedlet isopropanol. Isopropanol \u00E4ndrar funktionen p\u00E5 handspriten vilket klassificeras som en slags denaturering."@sv , "Denaturace je v biochemii vratn\u00FD nebo nevratn\u00FD proces, p\u0159i n\u011Bm\u017E \u00FA\u010Dinkem jist\u00FDch fyzik\u00E1ln\u00EDch \u010Di chemick\u00FDch zm\u011Bn doch\u00E1z\u00ED k zm\u011Bn\u00E1m prostorov\u00E9 struktury n\u011Bkter\u00FDch biomolekul z p\u016Fvodn\u00EDho p\u0159irozen\u00E9ho stavu. Denaturovat mohou b\u00EDlkoviny, ale i dvouvl\u00E1knov\u00E9 nukleov\u00E9 kyseliny (zejm\u00E9na DNA), p\u0159i\u010Dem\u017E oba tyto procesy se fundament\u00E1ln\u011B li\u0161\u00ED. Denaturace b\u00EDlkovin je prov\u00E1zena ztr\u00E1tou jejich prostorov\u00E9 sekund\u00E1rn\u00ED struktury, p\u0159i\u010Dem\u017E \u010Dasto doch\u00E1z\u00ED ke ztr\u00E1t\u011B rozpustnosti (k precipitaci). U dvouvl\u00E1knov\u00E9 DNA se denaturace projevuje jako odd\u011Blen\u00ED komplement\u00E1rn\u00EDch vl\u00E1ken v dvou\u0161roubovici. Pokud je proces denaturace vratn\u00FD (reverzibiln\u00ED), m\u016F\u017Ee doj\u00EDt k tzv. ."@cs . @prefix gold: . gold:hypernym dbr:Process . @prefix prov: . prov:wasDerivedFrom . @prefix xsd: . dbo:wikiPageLength "30481"^^xsd:nonNegativeInteger ; foaf:isPrimaryTopicOf .