. . "LMWPc"@en . "3.1.3.48" . . "PF01451"@en . . . "3"^^ . . . . . . . . "CL0031"@en . . . "Protein tyrosine phosphatase 1, trimer, Human"@en . . "\u86CB\u767D\u916A\u6C28\u9178\u78F7\u9178\u9176(protein tyrosine phosphatase)\u7684\u529F\u80FD\u662F\u53BB\u9664\u86CB\u767D\u4E0A\u78F7\u9178\u5316\u916A\u6C28\u9178\u7684\u78F7\u8102\u57FA\u56E2\u3002\u86CB\u767D\u916A\u6C28\u9178\u78F7\u9178\u5316\u662F\u4E00\u4E2A\u5E38\u89C1\u7684\u7FFB\u8BD1\u540E\u4FEE\u9970\uFF0C\u80FD\u591F\u4EA7\u751F\u65B0\u7684\u7528\u4E8E\u86CB\u767D\u76F8\u4E92\u4F5C\u7528\u4EE5\u53CA\u8C03\u8282\u7EC6\u80DE\u5185\u5206\u5E03\u7684\u8BC6\u522B\u4F4D\u70B9\uFF0C\u80FD\u591F\u5F71\u54CD\u86CB\u767D\u7684\u7A33\u5B9A\u6027\uFF0C\u4E5F\u80FD\u591F\u8C03\u63A7\u9176\u7684\u6D3B\u6027\u3002\u6B63\u56E0\u5982\u6B64\uFF0C\u7EF4\u6301\u4E00\u4E2A\u5408\u9002\u7684\u86CB\u767D\u916A\u6C28\u9178\u78F7\u9178\u5316\u7A0B\u5EA6\u5BF9\u5F88\u591A\u7EC6\u80DE\u529F\u80FD\u90FD\u662F\u81F3\u5173\u91CD\u8981\u7684\u3002\u916A\u6C28\u9178\u4E13\u4E00\u7684\u86CB\u767D\u78F7\u9178\u9176(PTPase; EC 3.1.3.48)\u50AC\u5316\u8131\u53BB\u916A\u6C28\u9178\u4E0A\u7684\u78F7\u8102\u57FA\u56E2\uFF0C\u6574\u4E2A\u8FC7\u7A0B\u901A\u8FC7\u4E00\u4E2A\u534A\u80F1\u6C28\u9178-\u78F7\u8102\u4E2D\u95F4\u4F53\u8FBE\u6210\u3002\u8FD9\u4E9B\u9176\u5728\uFF08\u6BD4\u5982MAP\u6FC0\u9176\u901A\u8DEF\uFF09\u53CA\u7EC6\u80DE\u5468\u671F\u63A7\u5236\u4E2D\u662F\u5F88\u5173\u952E\u7684\u8C03\u63A7\u539F\u4EF6\uFF0C\u5B83\u4EEC\u5728\u63A7\u5236\u7EC6\u80DE\u751F\u957F\u3001\u7E41\u6B96\u3001\u5206\u5316\u4EE5\u53CA\u8F6C\u5316\u4E2D\u4E5F\u5F88\u91CD\u8981\u3002"@zh . . "Low-molecular-weight phosphotyrosine protein phosphatase"@en . "SM00226"@en . . "PTPLA"@en . . . . . . . . . "IPR007482"@en . "79747"^^ . . "PF00102"@en . . . . "Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins: [a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate Protein tyrosine (pTyr) phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability, and regulate enzyme activity. As a consequence, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; EC 3.1.3.48) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation, transformation, and synaptic plasticity."@en . . . . "\u041F\u0440\u043E\u0442\u0435\u0457\u043D-\u0442\u0438\u0440\u043E\u0437\u0438\u043D-\u0444\u043E\u0441\u0444\u0430\u0442\u0430\u0437\u0438 \u2014 \u0446\u0435 \u0433\u0440\u0443\u043F\u0430 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0456\u0432, \u044F\u043A\u0456 \u043A\u0430\u0442\u0430\u043B\u0456\u0437\u0443\u044E\u0442\u044C \u0440\u0435\u0430\u043A\u0446\u0456\u044E \u0433\u0456\u0434\u0440\u043E\u043B\u0456\u0437\u0443 \u0444\u043E\u0441\u0444\u043E\u0435\u0444\u0456\u0440\u043D\u043E\u0433\u043E \u0437\u0432'\u044F\u0437\u043A\u0443 \u0444\u043E\u0441\u0444\u043E\u0442\u0438\u0440\u043E\u0437\u0438\u043D\u043E\u0432\u043E\u0433\u043E \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442\u043D\u043E\u0433\u043E \u0437\u0430\u043B\u0438\u0448\u043A\u0443 \u0440\u0456\u0437\u043D\u043E\u043C\u0430\u043D\u0456\u0442\u043D\u0438\u0445 \u0441\u0443\u0431\u0441\u0442\u0440\u0430\u0442\u0456\u0432 (\u0431\u0456\u043B\u043A\u0456\u0432). \u0424\u043E\u0441\u0444\u043E\u0440\u0438\u043B\u044E\u0432\u0430\u043D\u043D\u044F \u0431\u0456\u043B\u043A\u0456\u0432 \u0437\u0430 \u0437\u0430\u043B\u0438\u0448\u043A\u0430\u043C\u0438 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u0443 (pTyr) \u0454 \u043E\u0434\u043D\u0456\u0454\u044E \u0437 \u043D\u0430\u0439\u043F\u043E\u0448\u0438\u0440\u0435\u043D\u0456\u0448\u0438\u0445 \u043F\u043E\u0441\u0442\u0442\u0440\u0430\u043D\u0441\u043B\u044F\u0446\u0456\u0439\u043D\u0438\u0445 \u043C\u043E\u0434\u0438\u0444\u0456\u043A\u0430\u0446\u0456\u0439, \u044F\u043A\u0430 \u043C\u043E\u0436\u0435 \u0441\u0442\u0432\u043E\u0440\u044E\u0432\u0430\u0442\u0438 \u043D\u043E\u0432\u0456 \u0440\u043E\u0437\u043F\u0456\u0437\u043D\u0430\u0432\u0430\u043B\u044C\u043D\u0456 \u043C\u043E\u0442\u0438\u0432\u0438 \u0434\u043B\u044F \u0431\u0456\u043B\u043A\u043E\u0432\u0438\u0445 \u0432\u0437\u0430\u0454\u043C\u043E\u0434\u0456\u0439 \u0456 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u0457 \u043B\u043E\u043A\u0430\u043B\u0456\u0437\u0430\u0446\u0456\u0457, \u0432\u043F\u043B\u0438\u0432\u0430\u0442\u0438 \u043D\u0430 \u0441\u0442\u0430\u0431\u0456\u043B\u044C\u043D\u0456\u0441\u0442\u044C \u0431\u0456\u043B\u043A\u0430, \u0456 \u0440\u0435\u0433\u0443\u043B\u044E\u0432\u0430\u0442\u0438 \u0430\u043A\u0442\u0438\u0432\u043D\u0456\u0441\u0442\u044C \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0443. \u042F\u043A \u043D\u0430\u0441\u043B\u0456\u0434\u043E\u043A, \u043F\u0456\u0434\u0442\u0440\u0438\u043C\u043A\u0430 \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u043D\u043E\u0433\u043E \u0440\u0456\u0432\u043D\u044F \u0444\u043E\u0441\u0444\u043E\u0440\u0438\u043B\u044E\u0432\u0430\u043D\u043D\u044F \u0431\u0456\u043B\u043A\u0456\u0432 \u0437\u0430 \u0437\u0430\u043B\u0438\u0448\u043A\u0430\u043C\u0438 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u0443 \u043C\u0430\u0454 \u0432\u0430\u0436\u043B\u0438\u0432\u0435 \u0437\u043D\u0430\u0447\u0435\u043D\u043D\u044F \u0434\u043B\u044F \u0431\u0430\u0433\u0430\u0442\u044C\u043E\u0445 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0438\u0445 \u0444\u0443\u043D\u043A\u0446\u0456\u0439. \u0422\u0438\u0440\u043E\u0437\u0438\u043D-\u0441\u043F\u0435\u0446\u0438\u0444\u0456\u0447\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0444\u043E\u0441\u0444\u0430\u0442\u0430\u0437\u0438 \u043A\u0430\u0442\u0430\u043B\u0456\u0437\u0443\u044E\u0442\u044C \u0433\u0456\u0434\u0440\u043E\u043B\u0456\u0437 \u0444\u043E\u0441\u0444\u043E\u0435\u0444\u0456\u0440\u043D\u043E\u0433\u043E \u0437\u0432'\u044F\u0437\u043A\u0443 \u0447\u0435\u0440\u0435\u0437 \u0444\u043E\u0440\u043C\u0443\u0432\u0430\u043D\u043D\u044F \u0446\u0438\u0441\u0442\u0435\u0457\u043D\u0456\u043B-\u0444\u043E\u0441\u0444\u0430\u0442\u043D\u043E\u0433\u043E \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u043D\u043E\u0433\u043E \u043F\u0440\u043E\u043C\u0456\u0436\u043D\u043E\u0433\u043E \u043A\u043E\u043C\u043F\u043B\u0435\u043A\u0441\u0443. \u0426\u0456 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0438 \u0454 \u043A\u043B\u044E\u0447\u043E\u0432\u0438\u043C\u0438 \u0440\u0435\u0433\u0443\u043B\u044F\u0442\u043E\u0440\u043D\u0438\u043C\u0438 \u043A\u043E\u043C\u043F\u043E\u043D\u0435\u043D\u0442\u0430\u043C\u0438 \u0432 \u0448\u043B\u044F\u0445\u0430\u0445 \u0441\u0438\u0433\u043D\u0430\u043B\u044C\u043D\u043E\u0457 \u0442\u0440\u0430\u043D\u0441\u0434\u0443\u043A\u0446\u0456\u0457 (\u043D\u0430\u043F\u0440\u0438\u043A\u043B\u0430\u0434, \u041C\u0410\u0420-\u043A\u0456\u043D\u0430\u0437\u043D\u0456 \u0448\u043B\u044F\u0445\u0438) \u0442\u0430 \u043A\u043E\u043D\u0442\u0440\u043E\u043B\u0456 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u0433\u043E \u0446\u0438\u043A\u043B\u0443 \u0439 \u0433\u0440\u0430\u044E\u0442\u044C \u0432\u0430\u0436\u043B\u0438\u0432\u0443 \u0440\u043E\u043B\u044C \u0432 \u043A\u043E\u043D\u0442\u0440\u043E\u043B\u0456 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u0433\u043E \u0440\u043E\u0441\u0442\u0443, \u043F\u0440\u043E\u043B\u0456\u0444\u0435\u0440\u0430\u0446\u0456\u0457, \u0434\u0438\u0444\u0435\u0440\u0435\u043D\u0446\u0456\u044E\u0432\u0430\u043D\u043D\u044F, \u0442\u0440\u0430\u043D\u0441\u0444\u043E\u0440\u043C\u0430\u0446\u0456\u0457 \u0456 \u0441\u0438\u043D\u0430\u043F\u0442\u0438\u0447\u043D\u043E\u0457 \u043F\u043B\u0430\u0441\u0442\u0438\u0447\u043D\u043E\u0441\u0442\u0456."@uk . "Protein-tyrosine phosphatase, SIW14-like"@en . . "Le proteina tirosin-fosfatasi (PTPasi; EC 3.1.3.3.48) sono un gruppo di enzimi in grado di rimuovere nelle proteine i gruppi fosfato dai residui di tirosina fosforilata. La fosforilazione della tirosina proteica (pTyr) \u00E8 una modificazione post-traduzionale comune che pu\u00F2 creare nuovi motivi di riconoscimento per le interazioni proteiche e la localizzazione cellulare, influenzare la stabilit\u00E0 proteica e regolare l'attivit\u00E0 enzimatica. Di conseguenza, mantenere un livello appropriato di fosforilazione della tirosina proteica \u00E8 essenziale per molte funzioni cellulari. Queste fosfatasi specifiche della tirosina catalizzano la rimozione di un gruppo fosfato collegato ad un residuo di tirosina, utilizzando un enzima intermedio enzimatico cisteinil-fosfato. Questi enzimi sono componenti chiave ne"@it . . "Y_phosphatase"@en . . . . . "Protein tyrosine phosphatase"@en . . . . . "Structure of a low-molecular-weight phosphotyrosine protein phosphatase."@en . . . . . . . "La prot\u00E9ine tyrosine phosphatase est une hydrolase qui catalyse la r\u00E9action : O-phospho-L-tyrosine-[prot\u00E9ine] + H2O L-tyrosine-[prot\u00E9ine] + phosphate. Il s'agit d'un groupe d'enzymes qui clivent les groupes phosphate des r\u00E9sidus de tyrosine phosphoryl\u00E9s sur les prot\u00E9ines. La phosphorylation des r\u00E9sidus de tyrosine est une modification post-traductionnelle courante susceptible de g\u00E9n\u00E9rer des motifs de reconnaissance mol\u00E9culaire pour les interactions entre prot\u00E9ines et la localisation cellulaire, d'affecter la stabilit\u00E9 de la prot\u00E9ine, et de r\u00E9guler l'activit\u00E9 enzymatique. Ces enzymes sont par cons\u00E9quent des \u00E9l\u00E9ments cl\u00E9s des voies m\u00E9taboliques de transduction de signal \u2014 comme la (en) \u2014 et du contr\u00F4le du cycle cellulaire, et jouent probablement un r\u00F4le important dans le contr\u00F4le du d\u00E9veloppement, de la prolif\u00E9ration et de la diff\u00E9renciation des cellules, ainsi que de leur transformation maligne (canc\u00E9rogen\u00E8se)."@fr . "cd00047"@en . "3295742"^^ . . "IPR000242"@en . . "PS50055"@en . ","@en . "PF03162"@en . "Dual-specificity phosphatase, catalytic domain"@en . . . . "\u041F\u0440\u043E\u0442\u0435\u0457\u043D-\u0442\u0438\u0440\u043E\u0437\u0438\u043D-\u0444\u043E\u0441\u0444\u0430\u0442\u0430\u0437\u0430"@uk . . . . . "Structure of a putative phosphoprotein phosphatase from Arabidopsis thaliana."@en . . . . . . . . "Structure of Yersinia protein tyrosine phosphatase."@en . . . "Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins: [a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate"@en . . "21671"^^ . . . "SM00194"@en . . . . "Prot\u00E9ine tyrosine phosphatase"@fr . . "\u86CB\u767D\u916A\u6C28\u9178\u78F7\u9178\u9176"@zh . . . . . . . "\u041F\u0440\u043E\u0442\u0435\u0457\u043D-\u0442\u0438\u0440\u043E\u0437\u0438\u043D-\u0444\u043E\u0441\u0444\u0430\u0442\u0430\u0437\u0438 \u2014 \u0446\u0435 \u0433\u0440\u0443\u043F\u0430 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0456\u0432, \u044F\u043A\u0456 \u043A\u0430\u0442\u0430\u043B\u0456\u0437\u0443\u044E\u0442\u044C \u0440\u0435\u0430\u043A\u0446\u0456\u044E \u0433\u0456\u0434\u0440\u043E\u043B\u0456\u0437\u0443 \u0444\u043E\u0441\u0444\u043E\u0435\u0444\u0456\u0440\u043D\u043E\u0433\u043E \u0437\u0432'\u044F\u0437\u043A\u0443 \u0444\u043E\u0441\u0444\u043E\u0442\u0438\u0440\u043E\u0437\u0438\u043D\u043E\u0432\u043E\u0433\u043E \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442\u043D\u043E\u0433\u043E \u0437\u0430\u043B\u0438\u0448\u043A\u0443 \u0440\u0456\u0437\u043D\u043E\u043C\u0430\u043D\u0456\u0442\u043D\u0438\u0445 \u0441\u0443\u0431\u0441\u0442\u0440\u0430\u0442\u0456\u0432 (\u0431\u0456\u043B\u043A\u0456\u0432). \u0424\u043E\u0441\u0444\u043E\u0440\u0438\u043B\u044E\u0432\u0430\u043D\u043D\u044F \u0431\u0456\u043B\u043A\u0456\u0432 \u0437\u0430 \u0437\u0430\u043B\u0438\u0448\u043A\u0430\u043C\u0438 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u0443 (pTyr) \u0454 \u043E\u0434\u043D\u0456\u0454\u044E \u0437 \u043D\u0430\u0439\u043F\u043E\u0448\u0438\u0440\u0435\u043D\u0456\u0448\u0438\u0445 \u043F\u043E\u0441\u0442\u0442\u0440\u0430\u043D\u0441\u043B\u044F\u0446\u0456\u0439\u043D\u0438\u0445 \u043C\u043E\u0434\u0438\u0444\u0456\u043A\u0430\u0446\u0456\u0439, \u044F\u043A\u0430 \u043C\u043E\u0436\u0435 \u0441\u0442\u0432\u043E\u0440\u044E\u0432\u0430\u0442\u0438 \u043D\u043E\u0432\u0456 \u0440\u043E\u0437\u043F\u0456\u0437\u043D\u0430\u0432\u0430\u043B\u044C\u043D\u0456 \u043C\u043E\u0442\u0438\u0432\u0438 \u0434\u043B\u044F \u0431\u0456\u043B\u043A\u043E\u0432\u0438\u0445 \u0432\u0437\u0430\u0454\u043C\u043E\u0434\u0456\u0439 \u0456 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u0457 \u043B\u043E\u043A\u0430\u043B\u0456\u0437\u0430\u0446\u0456\u0457, \u0432\u043F\u043B\u0438\u0432\u0430\u0442\u0438 \u043D\u0430 \u0441\u0442\u0430\u0431\u0456\u043B\u044C\u043D\u0456\u0441\u0442\u044C \u0431\u0456\u043B\u043A\u0430, \u0456 \u0440\u0435\u0433\u0443\u043B\u044E\u0432\u0430\u0442\u0438 \u0430\u043A\u0442\u0438\u0432\u043D\u0456\u0441\u0442\u044C \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0443. \u042F\u043A \u043D\u0430\u0441\u043B\u0456\u0434\u043E\u043A, \u043F\u0456\u0434\u0442\u0440\u0438\u043C\u043A\u0430 \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u043D\u043E\u0433\u043E \u0440\u0456\u0432\u043D\u044F \u0444\u043E\u0441\u0444\u043E\u0440\u0438\u043B\u044E\u0432\u0430\u043D\u043D\u044F \u0431\u0456\u043B\u043A\u0456\u0432 \u0437\u0430 \u0437\u0430\u043B\u0438\u0448\u043A\u0430\u043C\u0438 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u0443 \u043C\u0430\u0454 \u0432\u0430\u0436\u043B\u0438\u0432\u0435 \u0437\u043D\u0430\u0447\u0435\u043D\u043D\u044F \u0434\u043B\u044F \u0431\u0430\u0433\u0430\u0442\u044C\u043E\u0445 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0438\u0445 \u0444\u0443\u043D\u043A\u0446\u0456\u0439. \u0422\u0438\u0440\u043E\u0437\u0438\u043D-\u0441\u043F\u0435\u0446\u0438\u0444\u0456\u0447\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0444\u043E\u0441\u0444\u0430\u0442\u0430\u0437\u0438 \u043A\u0430\u0442\u0430\u043B\u0456\u0437\u0443\u044E\u0442\u044C \u0433\u0456\u0434\u0440\u043E\u043B\u0456\u0437 \u0444\u043E\u0441\u0444\u043E\u0435\u0444\u0456\u0440\u043D\u043E\u0433\u043E \u0437\u0432'\u044F\u0437\u043A\u0443 \u0447\u0435\u0440\u0435\u0437 \u0444\u043E\u0440\u043C\u0443\u0432\u0430\u043D\u043D\u044F \u0446\u0438\u0441\u0442\u0435\u0457\u043D\u0456\u043B-\u0444\u043E\u0441\u0444\u0430\u0442\u043D\u043E\u0433\u043E \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u043D\u043E\u0433\u043E \u043F\u0440\u043E\u043C\u0456\u0436\u043D\u043E\u0433\u043E \u043A\u043E\u043C\u043F\u043B\u0435\u043A\u0441\u0443. \u0426\u0456 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0438 \u0454 \u043A\u043B\u044E\u0447\u043E\u0432\u0438\u043C\u0438 \u0440\u0435\u0433\u0443\u043B\u044F\u0442\u043E\u0440\u043D\u0438\u043C\u0438 \u043A\u043E\u043C\u043F\u043E\u043D\u0435\u043D\u0442\u0430\u043C\u0438 \u0432 \u0448\u043B\u044F\u0445\u0430\u0445 "@uk . "IPR017867"@en . . . "La prot\u00E9ine tyrosine phosphatase est une hydrolase qui catalyse la r\u00E9action : O-phospho-L-tyrosine-[prot\u00E9ine] + H2O L-tyrosine-[prot\u00E9ine] + phosphate. Il s'agit d'un groupe d'enzymes qui clivent les groupes phosphate des r\u00E9sidus de tyrosine phosphoryl\u00E9s sur les prot\u00E9ines. La phosphorylation des r\u00E9sidus de tyrosine est une modification post-traductionnelle courante susceptible de g\u00E9n\u00E9rer des motifs de reconnaissance mol\u00E9culaire pour les interactions entre prot\u00E9ines et la localisation cellulaire, d'affecter la stabilit\u00E9 de la prot\u00E9ine, et de r\u00E9guler l'activit\u00E9 enzymatique. Ces enzymes sont par cons\u00E9quent des \u00E9l\u00E9ments cl\u00E9s des voies m\u00E9taboliques de transduction de signal \u2014 comme la (en) \u2014 et du contr\u00F4le du cycle cellulaire, et jouent probablement un r\u00F4le important dans le contr\u00F4le du d\u00E9ve"@fr . ", , , , , , , , ,"@en . . . . . "1105945878"^^ . "Protein-tyrosine phosphatase"@en . . . . "PF04387"@en . . "1"^^ . . "DSPc"@en . . . "\u86CB\u767D\u916A\u6C28\u9178\u78F7\u9178\u9176(protein tyrosine phosphatase)\u7684\u529F\u80FD\u662F\u53BB\u9664\u86CB\u767D\u4E0A\u78F7\u9178\u5316\u916A\u6C28\u9178\u7684\u78F7\u8102\u57FA\u56E2\u3002\u86CB\u767D\u916A\u6C28\u9178\u78F7\u9178\u5316\u662F\u4E00\u4E2A\u5E38\u89C1\u7684\u7FFB\u8BD1\u540E\u4FEE\u9970\uFF0C\u80FD\u591F\u4EA7\u751F\u65B0\u7684\u7528\u4E8E\u86CB\u767D\u76F8\u4E92\u4F5C\u7528\u4EE5\u53CA\u8C03\u8282\u7EC6\u80DE\u5185\u5206\u5E03\u7684\u8BC6\u522B\u4F4D\u70B9\uFF0C\u80FD\u591F\u5F71\u54CD\u86CB\u767D\u7684\u7A33\u5B9A\u6027\uFF0C\u4E5F\u80FD\u591F\u8C03\u63A7\u9176\u7684\u6D3B\u6027\u3002\u6B63\u56E0\u5982\u6B64\uFF0C\u7EF4\u6301\u4E00\u4E2A\u5408\u9002\u7684\u86CB\u767D\u916A\u6C28\u9178\u78F7\u9178\u5316\u7A0B\u5EA6\u5BF9\u5F88\u591A\u7EC6\u80DE\u529F\u80FD\u90FD\u662F\u81F3\u5173\u91CD\u8981\u7684\u3002\u916A\u6C28\u9178\u4E13\u4E00\u7684\u86CB\u767D\u78F7\u9178\u9176(PTPase; EC 3.1.3.48)\u50AC\u5316\u8131\u53BB\u916A\u6C28\u9178\u4E0A\u7684\u78F7\u8102\u57FA\u56E2\uFF0C\u6574\u4E2A\u8FC7\u7A0B\u901A\u8FC7\u4E00\u4E2A\u534A\u80F1\u6C28\u9178-\u78F7\u8102\u4E2D\u95F4\u4F53\u8FBE\u6210\u3002\u8FD9\u4E9B\u9176\u5728\uFF08\u6BD4\u5982MAP\u6FC0\u9176\u901A\u8DEF\uFF09\u53CA\u7EC6\u80DE\u5468\u671F\u63A7\u5236\u4E2D\u662F\u5F88\u5173\u952E\u7684\u8C03\u63A7\u539F\u4EF6\uFF0C\u5B83\u4EEC\u5728\u63A7\u5236\u7EC6\u80DE\u751F\u957F\u3001\u7E41\u6B96\u3001\u5206\u5316\u4EE5\u53CA\u8F6C\u5316\u4E2D\u4E5F\u5F88\u91CD\u8981\u3002"@zh . . . . . "Y_phosphatase2"@en . . . "Protein-tyrosine-phosphatase"@en . "PDOC00323"@en . . . . "PF00782"@en . . "3.1"^^ . . "Le proteina tirosin-fosfatasi (PTPasi; EC 3.1.3.3.48) sono un gruppo di enzimi in grado di rimuovere nelle proteine i gruppi fosfato dai residui di tirosina fosforilata. La fosforilazione della tirosina proteica (pTyr) \u00E8 una modificazione post-traduzionale comune che pu\u00F2 creare nuovi motivi di riconoscimento per le interazioni proteiche e la localizzazione cellulare, influenzare la stabilit\u00E0 proteica e regolare l'attivit\u00E0 enzimatica. Di conseguenza, mantenere un livello appropriato di fosforilazione della tirosina proteica \u00E8 essenziale per molte funzioni cellulari. Queste fosfatasi specifiche della tirosina catalizzano la rimozione di un gruppo fosfato collegato ad un residuo di tirosina, utilizzando un enzima intermedio enzimatico cisteinil-fosfato. Questi enzimi sono componenti chiave nella regolazione delle e del , ma sono anche importanti nel controllo della , della , della differenziazione, della trasformazione e della plasticit\u00E0 sinaptica."@it . . . . . . . . . . . . . "IPR000340"@en . "Protein-tyrosine phosphatase-like, PTPLA"@en . . "cd14498"@en . "IPR004861"@en . . . . . . . . . . . . . . "Proteina tirosin-fosfatasi"@it . . "270"^^ . . "cd00115"@en . . . . "Structure of the dual-specificity protein phosphatase VHR."@en . . "cd14528"@en . . "Protein-tyrosine-phosphatase"@en . . . . .