. . . "Un virus oncolitico \u00E8 un virus che infetta e uccide preferenzialmente le cellule tumorali. Una volta che le cellule tumorali infettate vengono distrutte tramite oncolisi, rilasciano nuove particelle virali infettive, o virioni, che contribuiscono loro stessi a a distruggere le cellule residue del tumore. I virus oncolitici sono pensati solo per provocare la distruzione delle cellule tumorali, ma anche di stimolare la risposta immunitaria al tumore da parte dell'ospite. Il potenziale dei virus come agenti antitumorali \u00E8 stato pensato all'inizio del XX secolo, anche se gli sforzi di ricerca coordinati non sono iniziati fino agli anni 1960. Un certo numero di virus, compresi gli adenovirus, i reoviridae, il virus del morbillo, l'herpes simplex, il virus della malattia di Newcastle sono stati clinicamente testati come agenti oncolitici. La maggior parte dei virus oncolitici attuali sono stati scelti per essere selettivi verso un tumore specifico. Il primo virus oncolitico ad essere approvato da una agenzia di regolamentazione \u00E8 un adenovirus oncolitico geneticamente modificato, nominato H101 dalla societ\u00E0 cinese, Shanghai Sunway Biotech Nel 2005 ottenne l'approvazione della China Food and Drug Administration per il trattamento del tumore della testa e del collo."@it . . . . . . . "Un virus oncolytique est un virus qui peut tuer pr\u00E9f\u00E9rentiellement les cellules canc\u00E9reuses. Apr\u00E8s l'oncolyse des cellules, d'autres particules virales ou virions sont produites, susceptibles de d\u00E9truire le reste de la tumeur."@fr . . "yes"@en . . . . . . . . . . . . . . "Virus oncol\u00EDtico"@es . . . . "70236"^^ . . 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\u0627\u0644\u0627\u0633\u062A\u0634\u0627\u0631\u064A\u0629 \u0627\u0644\u0645\u0639\u0646\u064A\u0629 \u0628\u0627\u0644\u0623\u062F\u0648\u064A\u0629 \u0627\u0644\u062A\u0627\u0628\u0639\u0629 \u0644\u0644\u062C\u0646\u0629 \u0625\u062F\u0627\u0631\u0629 \u0627\u0644\u0623\u063A\u0630\u064A\u0629 \u0648\u0627\u0644\u0623\u062F\u0648\u064A\u0629 \u0648\u0627\u0644\u0644\u062C\u0646\u0629 \u0627\u0644\u0627\u0633\u062A\u0634\u0627\u0631\u064A\u0629 \u0644\u0644\u0639\u0644\u0627\u062C \u0627\u0644\u062E\u0644\u0648\u064A \u0648\u0627\u0644\u0623\u0646\u0633\u062C\u0629 \u0648\u0627\u0644\u062C\u064A\u0646\u0627\u062A \u0628\u0623\u0635\u0648\u0627\u062A 22-1 \u0644\u0644\u062A\u0648\u0635\u064A\u0629 \u0628\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062C \u0627\u0644\u0645\u0646\u0627\u0639\u064A \u0627\u0644\u0645\u064F\u062D\u0644\u0644."@ar . . "Wirus onkolityczny \u2013 zmodyfikowana genetycznie jednostka wirusowa, kt\u00F3rej zadaniem jest infekowanie i niszczenie kom\u00F3rek nowotworowych."@pl . . "An oncolytic virus is a virus that preferentially infects and kills cancer cells. As the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses. Oncolytic viruses also have the ability to affect the tumor micro-environment in multiples ways. The potential of viruses as anti-cancer agents was first realised in the early twentieth century, although coordinated research efforts did not begin until the 1960s. A number of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus, and vaccinia have been clinically tested as oncolytic agents. Most current oncolytic viruses are engineered for tumour selectivity, although there are naturally occurring examples such as reovirus and the senecavirus, resulting in clinical trials. The first oncolytic virus to be approved by a national regulatory agency was genetically unmodified ECHO-7 strain enterovirus RIGVIR, which was approved in Latvia in 2004 for the treatment of skin melanoma; the approval was withdrawn in 2019. An oncolytic adenovirus, a genetically modified adenovirus named H101, was approved in China in 2005 for the treatment of head and neck cancer. In 2015, talimogene laherparepvec (OncoVex, T-VEC), an oncolytic herpes virus which is a modified herpes simplex virus, became the first oncolytic virus to be approved for use in the U.S. and European Union, for the treatment of advanced inoperable melanoma."@en . . . . . . . "\u816B\u760D\u6EB6\u89E3\u6027\u30A6\u30A4\u30EB\u30B9\uFF08\u3057\u3085\u3088\u3046\u3088\u3046\u304B\u3044\u305B\u3044\u30A6\u30A4\u30EB\u30B9\u3001\u82F1: oncolytic virus\uFF09\u3068\u306F\u3001\u60AA\u6027\u816B\u760D\uFF08\u764C\uFF09\u306E\u7D30\u80DE\u306B\u611F\u67D3\u3057\u3066\u3053\u308C\u3092\u7D30\u80DE\u6B7B\u3055\u305B\u308B\u30A6\u30A4\u30EB\u30B9\u306E\u7DCF\u79F0\u3067\u3042\u308B\u3002\u611F\u67D3\u3057\u305F\u764C\u7D30\u80DE\u306F\u878D\u89E3\u3057\u3001\u611F\u67D3\u6027\u3092\u6301\u3064\u65B0\u305F\u306A\u30A6\u30A4\u30EB\u30B9\u7C92\u5B50\u3092\u653E\u51FA\u3057\u3066\u4ED6\u306E\u764C\u7D30\u80DE\u306B\u611F\u67D3\u3059\u308B\u3002\u816B\u760D\u6EB6\u89E3\u6027\u30A6\u30A4\u30EB\u30B9\u306F\u816B\u760D\u7D30\u80DE\u3092\u76F4\u63A5\u6B7B\u306B\u81F3\u3089\u3057\u3081\u308B\u306E\u307F\u306A\u3089\u305A\u3001\u5BBF\u4E3B\u306E\u6297\u816B\u760D\u514D\u75AB\u6D3B\u6027\u3092\u4E0A\u6607\u3055\u305B\u308B\u3002 \u6297\u816B\u760D\u85AC\u3068\u3057\u3066\u306E\u30A6\u30A4\u30EB\u30B9\u306E\u53EF\u80FD\u6027\u306F20\u4E16\u7D00\u306E\u521D\u982D\u304B\u3089\u6A21\u7D22\u3055\u308C\u59CB\u3081\u305F\u3002\u5F53\u521D\u306F\u672A\u7CBE\u88FD\u306E\u65B0\u898F\u30A6\u30A4\u30EB\u30B9\u304C\u7528\u3044\u3089\u308C\u305F\u304C\u30011960\u5E74\u4EE3\u306B\u306A\u308B\u3068\u30A6\u30A4\u30EB\u30B9\u3092\u53B3\u9078\u3057\u7CBE\u88FD\u3057\u3066\u4F7F\u7528\u3059\u308B\u69D8\u306B\u306A\u3063\u305F\u3002\u30A2\u30C7\u30CE\u30A6\u30A4\u30EB\u30B9\u3001\u30EC\u30AA\u30A6\u30A4\u30EB\u30B9\u3001\u9EBB\u75B9\u30A6\u30A4\u30EB\u30B9\u3001\u5358\u7D14\u30D8\u30EB\u30DA\u30B9\u30A6\u30A4\u30EB\u30B9\u3001\u30CB\u30E5\u30FC\u30AB\u30C3\u30B9\u30EB\u75C5\u30A6\u30A4\u30EB\u30B9\u3001\u725B\u75D8\u30A6\u30A4\u30EB\u30B9\u306A\u3069\u306E\u591A\u304F\u306E\u30A6\u30A4\u30EB\u30B9\u304C\u81E8\u5E8A\u958B\u767A\u306E\u9014\u4E0A\u306B\u3042\u308B\u3002\u6700\u65B0\u306E\u816B\u760D\u6EB6\u89E3\u6027\u30A6\u30A4\u30EB\u30B9\u306F\u3001\u30EC\u30AA\u30A6\u30A4\u30EB\u30B9\u3084\uFF08SVV-001\uFF09\u3068\u3044\u3063\u305F\u81EA\u7136\u306B\u5B58\u5728\u3059\u308B\u30A6\u30A4\u30EB\u30B9\u3092\u816B\u760D\u9078\u629E\u6027\u3092\u9AD8\u3081\u308B\u69D8\u306B\u6539\u826F\u3057\u3066\u4F5C\u6210\u3055\u308C\u3066\u304A\u308A\u3001\u81E8\u5E8A\u8A66\u9A13\u3084\u88FD\u9020\u30FB\u8CA9\u58F2\u627F\u8A8D\u306B\u81F3\u3063\u305F\u3082\u306E\u3082\u3042\u308B\u3002"@ja . . . "\u816B\u760D\u6EB6\u89E3\u6027\u30A6\u30A4\u30EB\u30B9\uFF08\u3057\u3085\u3088\u3046\u3088\u3046\u304B\u3044\u305B\u3044\u30A6\u30A4\u30EB\u30B9\u3001\u82F1: oncolytic virus\uFF09\u3068\u306F\u3001\u60AA\u6027\u816B\u760D\uFF08\u764C\uFF09\u306E\u7D30\u80DE\u306B\u611F\u67D3\u3057\u3066\u3053\u308C\u3092\u7D30\u80DE\u6B7B\u3055\u305B\u308B\u30A6\u30A4\u30EB\u30B9\u306E\u7DCF\u79F0\u3067\u3042\u308B\u3002\u611F\u67D3\u3057\u305F\u764C\u7D30\u80DE\u306F\u878D\u89E3\u3057\u3001\u611F\u67D3\u6027\u3092\u6301\u3064\u65B0\u305F\u306A\u30A6\u30A4\u30EB\u30B9\u7C92\u5B50\u3092\u653E\u51FA\u3057\u3066\u4ED6\u306E\u764C\u7D30\u80DE\u306B\u611F\u67D3\u3059\u308B\u3002\u816B\u760D\u6EB6\u89E3\u6027\u30A6\u30A4\u30EB\u30B9\u306F\u816B\u760D\u7D30\u80DE\u3092\u76F4\u63A5\u6B7B\u306B\u81F3\u3089\u3057\u3081\u308B\u306E\u307F\u306A\u3089\u305A\u3001\u5BBF\u4E3B\u306E\u6297\u816B\u760D\u514D\u75AB\u6D3B\u6027\u3092\u4E0A\u6607\u3055\u305B\u308B\u3002 \u6297\u816B\u760D\u85AC\u3068\u3057\u3066\u306E\u30A6\u30A4\u30EB\u30B9\u306E\u53EF\u80FD\u6027\u306F20\u4E16\u7D00\u306E\u521D\u982D\u304B\u3089\u6A21\u7D22\u3055\u308C\u59CB\u3081\u305F\u3002\u5F53\u521D\u306F\u672A\u7CBE\u88FD\u306E\u65B0\u898F\u30A6\u30A4\u30EB\u30B9\u304C\u7528\u3044\u3089\u308C\u305F\u304C\u30011960\u5E74\u4EE3\u306B\u306A\u308B\u3068\u30A6\u30A4\u30EB\u30B9\u3092\u53B3\u9078\u3057\u7CBE\u88FD\u3057\u3066\u4F7F\u7528\u3059\u308B\u69D8\u306B\u306A\u3063\u305F\u3002\u30A2\u30C7\u30CE\u30A6\u30A4\u30EB\u30B9\u3001\u30EC\u30AA\u30A6\u30A4\u30EB\u30B9\u3001\u9EBB\u75B9\u30A6\u30A4\u30EB\u30B9\u3001\u5358\u7D14\u30D8\u30EB\u30DA\u30B9\u30A6\u30A4\u30EB\u30B9\u3001\u30CB\u30E5\u30FC\u30AB\u30C3\u30B9\u30EB\u75C5\u30A6\u30A4\u30EB\u30B9\u3001\u725B\u75D8\u30A6\u30A4\u30EB\u30B9\u306A\u3069\u306E\u591A\u304F\u306E\u30A6\u30A4\u30EB\u30B9\u304C\u81E8\u5E8A\u958B\u767A\u306E\u9014\u4E0A\u306B\u3042\u308B\u3002\u6700\u65B0\u306E\u816B\u760D\u6EB6\u89E3\u6027\u30A6\u30A4\u30EB\u30B9\u306F\u3001\u30EC\u30AA\u30A6\u30A4\u30EB\u30B9\u3084\uFF08SVV-001\uFF09\u3068\u3044\u3063\u305F\u81EA\u7136\u306B\u5B58\u5728\u3059\u308B\u30A6\u30A4\u30EB\u30B9\u3092\u816B\u760D\u9078\u629E\u6027\u3092\u9AD8\u3081\u308B\u69D8\u306B\u6539\u826F\u3057\u3066\u4F5C\u6210\u3055\u308C\u3066\u304A\u308A\u3001\u81E8\u5E8A\u8A66\u9A13\u3084\u88FD\u9020\u30FB\u8CA9\u58F2\u627F\u8A8D\u306B\u81F3\u3063\u305F\u3082\u306E\u3082\u3042\u308B\u3002 2011\u5E74\u6642\u70B9\u3067\u306F\u30D2\u30C8\u3067\u306E\u8A66\u9A13\u304C\u5B9F\u65BD\u3055\u308C\u305F\u3082\u306E\u306F\u5C11\u306A\u304B\u3063\u305F\u3002\uFF08OncoVex\u3001T-VEC\uFF09\u306F\u7B2CIII\u76F8\u81E8\u5E8A\u8A66\u9A13\u306E\u4E2D\u9593\u89E3\u6790\u7D50\u679C\u304C\u826F\u597D\u3067\u3042\u308B\u3053\u3068\u30922012\u5E741\u6708\u306B\u767A\u8868\u3057\u30012015\u5E7412\u6708\uFF08\u9032\u884C\u60AA\u6027\u9ED2\u8272\u816B\u306E\u6CBB\u7642\u85AC\u3068\u3057\u3066\uFF09\u6700\u521D\u306B\u627F\u8A8D\u3055\u308C\u305F\u30A6\u30A4\u30EB\u30B9\u3068\u306A\u3063\u305F\u3002\u61D0\u7591\u8AD6\u8005\u306F\u3001\u767A\u8868\u3055\u308C\u306A\u304B\u3063\u305F\u5168\u751F\u5B58\u671F\u9593\u3053\u305D\u304C\u6700\u7D42\u7684\u306A\u5224\u65AD\u306E\u6750\u6599\u3068\u306A\u308B\u3053\u3068\u3092\u7406\u7531\u306B\u4E2D\u9593\u89E3\u6790\u7D50\u679C\u306E\u81E8\u5E8A\u7684\u59A5\u5F53\u6027\u306B\u3064\u3044\u3066\u7591\u7FA9\u3092\u7533\u3057\u7ACB\u3066\u3066\u3044\u305F\u3002\u307E\u305F\u3053\u306E\u6CBB\u7642\u6CD5\u306F\u4ED6\u306E\u6CBB\u7642\u6CD5\u3068\u7D44\u307F\u5408\u308F\u3055\u308C\u308B\u4E8B\u3067\u6709\u52B9\u6027\u304C\u6700\u5927\u5316\u3055\u308C\u308B\u3068\u3082\u8A00\u3063\u3066\u3044\u308B\u3002"@ja . . . . . . . . "Virus onkolisis adalah virus yang secara khusus menginfeksi dan membunuh sel kanker. Terapi virus onkolisis didasarkan pada replikasi selektif virus pada sel kanker dan penyebaran selanjutnya di dalam tumor tanpa menyebabkan kerusakan pada jaringan normal. Virus onkolisis diperkirakan tidak hanya menyebabkan kerusakan sel tumor secara langsung, tetapi juga untuk merangsang respon imun antitumor pada inang."@in . "Onkolytische Viren sind Viren, die direkt oder indirekt Tumorzellen t\u00F6ten. Onkolytische Viren besitzen verschiedene Wirkungsmechanismen, z. B. indem sie Tumorzellen infizieren und lysieren, eine Immunantwort erzeugen oder Toxine und Tumorsuppressorgene in Tumorzellen einf\u00FChren. Sie werden experimentell im Rahmen einer onkolytischen Virotherapie (englisch: oncolytic cancer virotherapy) zur Therapie von Krebserkrankungen eingesetzt."@de . "Un virus oncolitico \u00E8 un virus che infetta e uccide preferenzialmente le cellule tumorali. Una volta che le cellule tumorali infettate vengono distrutte tramite oncolisi, rilasciano nuove particelle virali infettive, o virioni, che contribuiscono loro stessi a a distruggere le cellule residue del tumore. I virus oncolitici sono pensati solo per provocare la distruzione delle cellule tumorali, ma anche di stimolare la risposta immunitaria al tumore da parte dell'ospite."@it . . . . . . . . . "1119974079"^^ . . "En el campo de la oncolog\u00EDa, la terapia g\u00E9nica puede utilizar virus oncol\u00EDticos, una de las estrategias m\u00E1s novedosas para eliminar o revertir el desarrollo de un tumor canceroso en el organismo. El uso de estos virus con fines terap\u00E9uticos recibe el nombre de Viroterapia. Estos virus, aunque han sido los \u00FAltimos en llegar a experimentaci\u00F3n cl\u00EDnica, presentan un futuro prometedor en cuanto a protocolos de terapia g\u00E9nica contra el c\u00E1ncer. La terapia viral utiliza dos tipos de virus oncol\u00EDticos: el adenovirus que ocasiona los resfriados y la vaccinia, que causa la viruela y se utiliza tambi\u00E9n en vacunas. A estos virus se les ha modificado alguno de sus genes para que s\u00F3lo puedan replicarse en c\u00E9lulas tumorales y no en normales. Idealmente los virus oncol\u00EDticos insertados en un tumor se dividir\u00E1n en las c\u00E9lulas tumorales, elimin\u00E1ndolas a la vez que generan nuevos virus, los cuales a su vez infectar\u00E1n a las c\u00E9lulas tumorales colindantes y as\u00ED sucesivamente, hasta que no queden c\u00E9lulas tumorales donde replicarse y hacer ciclo l\u00EDtico. En la actualidad existen varios ensayos cl\u00EDnicos con \u00E9xito que emplean estos virus contra diversos c\u00E1nceres humanos. Un ejemplo ser\u00EDa el virus oncol\u00EDtico , que es un adenovirus al que se le ha quitado la prote\u00EDna viral implicada en la replicaci\u00F3n de forma que, sin ella, no puede replicarse en una c\u00E9lula que contenga p53 funcional, es decir, en c\u00E9lulas normales. En cambio, las c\u00E9lulas tumorales presentan p53 alterado, por lo que permiten la replicaci\u00F3n de dicho virus dando lugar, finalmente, a la lisis de estas c\u00E9lulas. Este tipo de estrategia implica la necesidad de conocer con exactitud la biolog\u00EDa y la gen\u00E9tica tanto de los virus utilizados como de las c\u00E9lulas tumorales a eliminar. Se administran por v\u00EDa intravenosa, no por inyecci\u00F3n en el mismo tumor, ya que los virus van teledirigidos hacia hacia su meta y tambi\u00E9n atacan a las met\u00E1stasis. Diversas l\u00EDneas de investigaci\u00F3n dise\u00F1an tambi\u00E9n genes de virus para que hagan a las c\u00E9lulas tumorales m\u00E1s susceptibles de ser da\u00F1adas por la quimioterapia y tambi\u00E9n hay ensayos para probar el efecto del virus herpes en personas con melanoma avanzado y met\u00E1stasis. Otros ensayos con viroterapia se prueban frente al c\u00E1ncer de h\u00EDgado, de cuello y de colon. Actualmente se est\u00E1n haciendo pruebas con este tratamiento para neuroblastomas infantiles en el Hospital Ni\u00F1o Jes\u00FAs de Madrid, Espa\u00F1a. Es un tratamiento muy prometedor, este estudio consiste en extraer las c\u00E9lulas mesenquinales de los ni\u00F1os, con una aspiraci\u00F3n de m\u00E9dula de las crestas il\u00EDacas, las cultivan durante 3 o 4 semanas y luego las infectan con el adenovirus como una transfusi\u00F3n de sangre, produci\u00E9ndose en algunos casos la curaci\u00F3n. A\u00FAn no se sabe con certeza qu\u00E9 es lo que determina el \u00E9xito en algunos pacientes y no en otros.\u200B En septiembre de 2013 se abrir\u00E1 otro ensayo, para tumores cerebrales malignos, con el adenovirus Delta24-RGD, al que se privado de una prote\u00EDna E1A funcionante. Esto hace que el virus no puede replicar m\u00E1s que en c\u00E9lulas con alteraci\u00F3n en la v\u00EDa del retinoblastoma, por lo que si se inyecta en cerebro, puede crecer y destruir c\u00E9lulas de tumores cerebrales pero no las c\u00E9lulas sanas. Este modelo se ha probado recientemente en el centro oncol\u00F3gico MDAnderson Cancer Center, en Houston, y se abre ahora un nuevo ensayo que se realiza en la Cl\u00EDnica Universidad de Navarra. Se incluir\u00E1n pacientes con glioblastoma en los que el tumor vuelve a crecer por primera vez despu\u00E9s del tratamiento est\u00E1ndar con radioterapia y temozolomida.\u200B El glioblastoma es un tumor muy agresivo en el que los tratamientos convencionales suelen fracasar. Seleccionando pacientes en esta fase, se pretende tratar el tumor con el virus antes de que el paciente se haya deteriorado mucho por m\u00FAltiples l\u00EDneas de quimioterapia."@es . . . . . . . . . . . . . . . . . . "Wirus onkolityczny \u2013 zmodyfikowana genetycznie jednostka wirusowa, kt\u00F3rej zadaniem jest infekowanie i niszczenie kom\u00F3rek nowotworowych."@pl . . . . . . "Onkolytische Viren sind Viren, die direkt oder indirekt Tumorzellen t\u00F6ten. Onkolytische Viren besitzen verschiedene Wirkungsmechanismen, z. B. indem sie Tumorzellen infizieren und lysieren, eine Immunantwort erzeugen oder Toxine und Tumorsuppressorgene in Tumorzellen einf\u00FChren. Sie werden experimentell im Rahmen einer onkolytischen Virotherapie (englisch: oncolytic cancer virotherapy) zur Therapie von Krebserkrankungen eingesetzt."@de . . . . . . . . . . . . . . "1723667"^^ . "Virus onkolisis adalah virus yang secara khusus menginfeksi dan membunuh sel kanker. Terapi virus onkolisis didasarkan pada replikasi selektif virus pada sel kanker dan penyebaran selanjutnya di dalam tumor tanpa menyebabkan kerusakan pada jaringan normal. Virus onkolisis diperkirakan tidak hanya menyebabkan kerusakan sel tumor secara langsung, tetapi juga untuk merangsang respon imun antitumor pada inang."@in . . . . . "En el campo de la oncolog\u00EDa, la terapia g\u00E9nica puede utilizar virus oncol\u00EDticos, una de las estrategias m\u00E1s novedosas para eliminar o revertir el desarrollo de un tumor canceroso en el organismo. El uso de estos virus con fines terap\u00E9uticos recibe el nombre de Viroterapia. Estos virus, aunque han sido los \u00FAltimos en llegar a experimentaci\u00F3n cl\u00EDnica, presentan un futuro prometedor en cuanto a protocolos de terapia g\u00E9nica contra el c\u00E1ncer. La terapia viral utiliza dos tipos de virus oncol\u00EDticos: el adenovirus que ocasiona los resfriados y la vaccinia, que causa la viruela y se utiliza tambi\u00E9n en vacunas. A estos virus se les ha modificado alguno de sus genes para que s\u00F3lo puedan replicarse en c\u00E9lulas tumorales y no en normales. Idealmente los virus oncol\u00EDticos insertados en un tumor se divid"@es . . "\u816B\u760D\u6EB6\u89E3\u6027\u30A6\u30A4\u30EB\u30B9"@ja . "Virus onkolisis"@in . . . . "Virus oncolytique"@fr . "Un virus oncolytique est un virus qui peut tuer pr\u00E9f\u00E9rentiellement les cellules canc\u00E9reuses. Apr\u00E8s l'oncolyse des cellules, d'autres particules virales ou virions sont produites, susceptibles de d\u00E9truire le reste de la tumeur."@fr . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "\u0641\u064A\u0631\u0648\u0633 \u0645\u062D\u0644\u0644 \u0644\u0644\u0648\u0631\u0645"@ar . . . . . . . . . . . "Onkolytische Viren"@de . . . . . . . "Wirus onkolityczny"@pl . . . . . . . . . . . . . . . . . . . . . . "yes"@en . . "An oncolytic virus is a virus that preferentially infects and kills cancer cells. As the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses. Oncolytic viruses also have the ability to affect the tumor micro-environment in multiples ways."@en . . . . . .