. . . . "La sindrome di Lujan-Fryns (Lujan\u2013Fryns syndrome, LFS) \u00E8 una malattia genetica legata all'X che causa disabilit\u00E0 intellettiva da lieve a moderata e caratteristiche descritte come \"habitus marfanoide\", riferendosi a un gruppo di caratteristiche fisiche simili a quelle riscontrate nella sindrome di Marfan. Queste caratteristiche includono una statura alta e arti lunghi e snelli. La LFS \u00E8 anche associata ad anomalie psicopatologiche e comportamentali e presenta una serie di malformazioni che interessano il cervello e il cuore. Il disturbo \u00E8 ereditato in modo dominante legato all'X ed \u00E8 attribuito a una mutazione missenso nel gene MED12. Attualmente non esiste alcun trattamento o terapia per il malfunzionamento di MED12 e la causa esatta del disturbo rimane poco chiara."@it . . . . "" . "\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646-\u0641\u0631\u064A\u0646\u0633 \u0623\u0648 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646 \u0623\u0648 \u0627\u0644\u062A\u062E\u0644\u0641 \u0627\u0644\u0639\u0642\u0644\u064A \u0627\u0644\u0648\u0631\u0627\u062B\u064A \u0627\u0644\u0633\u0627\u0626\u062F \u0627\u0644\u0645\u0635\u062D\u0648\u0628 \u0628\u0623\u0639\u0631\u0627\u0636 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0645\u0627\u0631\u0641\u0627\u0646\u060C \u0647\u0648 \u0645\u0631\u0636 \u0648\u0631\u0627\u062B\u064A \u0633\u0627\u0626\u062F \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 X \u0627\u0644\u0630\u064A \u064A\u0633\u0628\u0628 \u062F\u0631\u062C\u0627\u062A \u0645\u062A\u0641\u0627\u0648\u062A\u0629 \u0645\u0646 \u0627\u0644\u062A\u062E\u0644\u0641 \u0627\u0644\u0639\u0642\u0644\u064A \u0627\u0644\u0637\u0641\u064A\u0641 \u0625\u0644\u0649 \u0627\u0644\u0645\u062A\u0648\u0633\u0637 \u0648\u0628\u0639\u0636 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0634\u0628\u064A\u0647\u0629 \u0628\u0623\u0639\u0631\u0627\u0636 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0645\u0627\u0631\u0641\u0627\u0646. \u062A\u0634\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0642\u0627\u0645\u0629 \u0627\u0644\u0646\u062D\u064A\u0641\u0629 \u0627\u0644\u0637\u0648\u064A\u0644\u0629\u060C \u0648\u0627\u0644\u0623\u0637\u0631\u0627\u0641 \u0627\u0644\u0637\u0648\u064A\u0644\u0629 \u0627\u0644\u0646\u062D\u064A\u0641\u0629. \u064A\u0635\u0627\u062D\u0628 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646-\u0641\u0631\u064A\u0646\u0633 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062A \u0623\u062E\u0631\u0649 \u0641\u064A \u0627\u0644\u0633\u0644\u0648\u0643 \u0648\u0628\u0639\u0636 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062A \u0627\u0644\u0646\u0641\u0633\u064A\u0629\u060C \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0628\u0639\u0636 \u0627\u0644\u062A\u0634\u0648\u0647\u0627\u062A \u0627\u0644\u062F\u0645\u0627\u063A\u064A\u0629 \u0648\u0627\u0644\u0642\u0644\u0628\u064A\u0629. \u062A\u062A\u062E\u0630 \u0627\u0644\u0635\u0648\u0631\u0629 \u0627\u0644\u0648\u0631\u0627\u062B\u064A\u0629 \u0644\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646-\u0641\u0631\u064A\u0646\u0633 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0633\u0627\u0626\u062F\u060C \u0648\u064A\u064F\u0639\u0632\u0649 \u0647\u0630\u0627 \u0625\u0644\u0649 \u0637\u0641\u0631\u0629 \u0641\u064A \u062C\u064A\u0646 \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 X. \u0644\u0627 \u064A\u0648\u062C\u062F \u0623\u064A \u0639\u0644\u0627\u062C \u0644\u0647\u0630\u0627 \u0627\u0644\u062E\u0644\u0644 \u0627\u0644\u062C\u064A\u0646\u064A \u0641\u064A \u0627\u0644\u0648\u0642\u062A \u0627\u0644\u062D\u0627\u0644\u064A\u060C \u0628\u064A\u0646\u0645\u0627 \u064A\u0638\u0644 \u0627\u0644\u0633\u0628\u0628 \u0627\u0644\u0631\u064A\u0633\u064A \u0644\u0647\u0630\u0627 \u0627\u0644\u062E\u0644\u0644 \u0627\u0644\u062C\u064A\u0646\u064A \u0645\u062C\u0647\u0648\u0644\u064B\u0627 \u062D\u062A\u0649 \u0648\u0642\u062A\u0646\u0627 \u0647\u0630\u0627."@ar . . "23798230"^^ . . . . . . . . . . . "" . . . . . . . . . . . . "Lujan\u2013Fryns syndrome (LFS) is an X-linked genetic disorder that causes mild to moderate intellectual disability and features described as Marfanoid habitus, referring to a group of physical characteristics similar to those found in Marfan syndrome. These features include a tall, thin stature and long, slender limbs. LFS is also associated with psychopathology and behavioral abnormalities, and it exhibits a number of malformations affecting the brain and heart. The disorder is inherited in an X-linked dominant manner, and is attributed to a missense mutation in the MED12 gene. There is currently no treatment or therapy for the underlying MED12 malfunction, and the exact cause of the disorder remains unclear."@en . "Lujan\u2013Fryns syndrome"@en . . . . . . . . . . . "40574"^^ . . . . "Zesp\u00F3\u0142 Lujana-Frynsa"@pl . . . "1116159250"^^ . . . . . . . . . "Le syndrome de Lujan-Fryns est une maladie g\u00E9n\u00E9tique touchant principalement les hommes et se manifestant par un retard mental, un faci\u00E8s caract\u00E9ristique, un aspect physique proche du syndrome de Marfan et des troubles du comportement. Le g\u00E8ne en cause et sa pr\u00E9valence sont inconnues."@fr . . . . . . . . . . . . . . . . . "300"^^ . . . . . . "MED12-Related Disorders"@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . "" . "\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646-\u0641\u0631\u064A\u0646\u0633"@ar . . . . . . . . . . . "Lujan\u2013Fryns syndrome in a young adult male, with features that include a long, narrow face and recessed chin."@en . . . . "Sindrome di Lujan-Fryns"@it . . . . . "\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646-\u0641\u0631\u064A\u0646\u0633 \u0623\u0648 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646 \u0623\u0648 \u0627\u0644\u062A\u062E\u0644\u0641 \u0627\u0644\u0639\u0642\u0644\u064A \u0627\u0644\u0648\u0631\u0627\u062B\u064A \u0627\u0644\u0633\u0627\u0626\u062F \u0627\u0644\u0645\u0635\u062D\u0648\u0628 \u0628\u0623\u0639\u0631\u0627\u0636 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0645\u0627\u0631\u0641\u0627\u0646\u060C \u0647\u0648 \u0645\u0631\u0636 \u0648\u0631\u0627\u062B\u064A \u0633\u0627\u0626\u062F \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 X \u0627\u0644\u0630\u064A \u064A\u0633\u0628\u0628 \u062F\u0631\u062C\u0627\u062A \u0645\u062A\u0641\u0627\u0648\u062A\u0629 \u0645\u0646 \u0627\u0644\u062A\u062E\u0644\u0641 \u0627\u0644\u0639\u0642\u0644\u064A \u0627\u0644\u0637\u0641\u064A\u0641 \u0625\u0644\u0649 \u0627\u0644\u0645\u062A\u0648\u0633\u0637 \u0648\u0628\u0639\u0636 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0634\u0628\u064A\u0647\u0629 \u0628\u0623\u0639\u0631\u0627\u0636 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0645\u0627\u0631\u0641\u0627\u0646. \u062A\u0634\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0642\u0627\u0645\u0629 \u0627\u0644\u0646\u062D\u064A\u0641\u0629 \u0627\u0644\u0637\u0648\u064A\u0644\u0629\u060C \u0648\u0627\u0644\u0623\u0637\u0631\u0627\u0641 \u0627\u0644\u0637\u0648\u064A\u0644\u0629 \u0627\u0644\u0646\u062D\u064A\u0641\u0629. \u064A\u0635\u0627\u062D\u0628 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646-\u0641\u0631\u064A\u0646\u0633 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062A \u0623\u062E\u0631\u0649 \u0641\u064A \u0627\u0644\u0633\u0644\u0648\u0643 \u0648\u0628\u0639\u0636 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062A \u0627\u0644\u0646\u0641\u0633\u064A\u0629\u060C \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0628\u0639\u0636 \u0627\u0644\u062A\u0634\u0648\u0647\u0627\u062A \u0627\u0644\u062F\u0645\u0627\u063A\u064A\u0629 \u0648\u0627\u0644\u0642\u0644\u0628\u064A\u0629. \u062A\u062A\u062E\u0630 \u0627\u0644\u0635\u0648\u0631\u0629 \u0627\u0644\u0648\u0631\u0627\u062B\u064A\u0629 \u0644\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0648\u062C\u0627\u0646-\u0641\u0631\u064A\u0646\u0633 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0633\u0627\u0626\u062F\u060C \u0648\u064A\u064F\u0639\u0632\u0649 \u0647\u0630\u0627 \u0625\u0644\u0649 \u0637\u0641\u0631\u0629 \u0641\u064A \u062C\u064A\u0646 \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 X."@ar . . . . "La sindrome di Lujan-Fryns (Lujan\u2013Fryns syndrome, LFS) \u00E8 una malattia genetica legata all'X che causa disabilit\u00E0 intellettiva da lieve a moderata e caratteristiche descritte come \"habitus marfanoide\", riferendosi a un gruppo di caratteristiche fisiche simili a quelle riscontrate nella sindrome di Marfan. Queste caratteristiche includono una statura alta e arti lunghi e snelli. La LFS \u00E8 anche associata ad anomalie psicopatologiche e comportamentali e presenta una serie di malformazioni che interessano il cervello e il cuore. Il disturbo \u00E8 ereditato in modo dominante legato all'X ed \u00E8 attribuito a una mutazione missenso nel gene MED12. Attualmente non esiste alcun trattamento o terapia per il malfunzionamento di MED12 e la causa esatta del disturbo rimane poco chiara."@it . . "Le syndrome de Lujan-Fryns est une maladie g\u00E9n\u00E9tique touchant principalement les hommes et se manifestant par un retard mental, un faci\u00E8s caract\u00E9ristique, un aspect physique proche du syndrome de Marfan et des troubles du comportement. Le g\u00E8ne en cause et sa pr\u00E9valence sont inconnues."@fr . . . . . . . . . "32654" . "Zesp\u00F3\u0142 Lujana-Frynsa (zesp\u00F3\u0142 Lujana, ang. Lujan-Fryns syndrome, Lujan syndrome, X-linked mental retardation with marfanoid habitus syndrome) \u2013 rzadki, genetycznie uwarunkowany zesp\u00F3\u0142 \u0142agodnego lub \u015Bredniego op\u00F3\u017Anienia umys\u0142owego, zwi\u0105zany z chromosomem X i dotykaj\u0105cy niemal wy\u0142\u0105cznie m\u0119\u017Cczyzn."@pl . . . . . . . . . . . . . . . . . "317" . . . . . . . "Syndrome de Lujan-Fryns"@fr . . . . . . . . . . . . . . . . . "Das Lujan-Fryns-Syndrom (LFS), auch als X-chromosomale geistige Retardierung-marfanoider Habitus-Syndrom bezeichnet, ist eine sehr seltene X-chromosomal vererbte Krankheit.Weitere Bezeichnung ist Mental retardation, X-linked 14."@de . . "Lujan-Fryns-Syndrom"@de . . . . "Lujan\u2013Fryns syndrome"@en . . . . . . "X-linked mental retardation with Marfanoid habitus, Lujan syndrome"@en . . "309520"^^ . . . . . . "Lujan\u2013Fryns syndrome"@en . "Zesp\u00F3\u0142 Lujana-Frynsa (zesp\u00F3\u0142 Lujana, ang. Lujan-Fryns syndrome, Lujan syndrome, X-linked mental retardation with marfanoid habitus syndrome) \u2013 rzadki, genetycznie uwarunkowany zesp\u00F3\u0142 \u0142agodnego lub \u015Bredniego op\u00F3\u017Anienia umys\u0142owego, zwi\u0105zany z chromosomem X i dotykaj\u0105cy niemal wy\u0142\u0105cznie m\u0119\u017Cczyzn."@pl . . . . . "Das Lujan-Fryns-Syndrom (LFS), auch als X-chromosomale geistige Retardierung-marfanoider Habitus-Syndrom bezeichnet, ist eine sehr seltene X-chromosomal vererbte Krankheit.Weitere Bezeichnung ist Mental retardation, X-linked 14."@de . . . . . . . . . . . "NBK1676" . . . . . . . "F70.1" . . . "Lujan\u2013Fryns syndrome (LFS) is an X-linked genetic disorder that causes mild to moderate intellectual disability and features described as Marfanoid habitus, referring to a group of physical characteristics similar to those found in Marfan syndrome. These features include a tall, thin stature and long, slender limbs. LFS is also associated with psychopathology and behavioral abnormalities, and it exhibits a number of malformations affecting the brain and heart. The disorder is inherited in an X-linked dominant manner, and is attributed to a missense mutation in the MED12 gene. There is currently no treatment or therapy for the underlying MED12 malfunction, and the exact cause of the disorder remains unclear."@en . . . . . . . . . . . . . . . . . . . .