. . "18809"^^ . "14179010"^^ . "EGR2"@es . . . . . . . . . . "Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells. It is later expressed in the neural crest derived cells of the cranial ganglion. The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early hindbrain development. It is evolutionarily conserved in vertebrates, humans, mice, chicks, and zebra fish. In addition, the amino acid sequence and most aspects of the embryonic gene pattern is conserved among vertebrates, further implicating its role in hindbrain development. When the Krox20 is deleted in mice, the protein coding ability of the Krox20 gene (including the DNA-binding domain of the zinc finger) is diminished. These mice are unable to survive after birth and exhibit major hindbrain defects. These defects include but are not limited to defects in formation of cranial sensory ganglia, partial fusion of the trigeminal nerve (V) with the facial (VII) and auditory (VII) nerves, the proximal nerve roots coming off of these ganglia were disorganized and intertwined among one another as they entered the brainstem, and there was fusion of the glossopharyngeal (IX) nerve complex."@en . . . "EGR2"@zh . "\u65E9\u671F\u751F\u957F\u53CD\u5E94\u86CB\u767D2\uFF08\u82F1\u8A9E\uFF1AEarly growth response protein 2\uFF0CEGR-2\uFF09\u662F\u4E00\u4E2A\u7531\u4EBA\u7C7B\u57FA\u56E0EGR2\u7F16\u7801\u7684\u86CB\u767D\u8D28\u3002 EGR2\u662F\u4E00\u4E2A\u8F6C\u5F55\u56E0\u5B50\uFF0C\u5305\u542B\u4E09\u4E2A\u4E32\u8054\u7684Cys2His2\u578B\u950C\u6307\u7ED3\u6784\uFF0C\u8BE5\u57FA\u56E0\u7684\u591A\u6001\u6027\u4E0EI\u578B\u8FDB\u884C\u6027\u795E\u7ECF\u6027\u8153\u9AA8\u808C\u840E\u7F29\u75C7\u6709\u5173\u3002"@zh . . . . . . . "La prote\u00EDna de respuesta temprana 2 es una prote\u00EDna que en los humanos se codifica a trav\u00E9s del gen EGR2. El EGR2 (tambi\u00E9n denominado Krox20) es una factor regulador de la transcripci\u00F3n, que contiene tres sitios de dedos de zinc de uni\u00F3n al ADN, y se expresa en mayor medida en una poblaci\u00F3n de c\u00E9lulas migratorias de la cresta neural. M\u00E1s tarde se expresa en las c\u00E9lulas de los ganglios craneales derivadas de la cresta neural. La prote\u00EDna codificada por el Krox20 contiene dos dedos de zinc del tipo cys2his2. La expresi\u00F3n del gen Krox20 es exclusiva del desarrollo temprano del rombenc\u00E9falo. La evoluci\u00F3n la ha conservado en vertebrados, humanos, ratones, polluelos y peces cebra. Adem\u00E1s, la secuencia de amino\u00E1cidos y la mayor\u00EDa de los aspectos relativos al patr\u00F3n g\u00E9nico embrionario que se conse"@es . "La prote\u00EDna de respuesta temprana 2 es una prote\u00EDna que en los humanos se codifica a trav\u00E9s del gen EGR2. El EGR2 (tambi\u00E9n denominado Krox20) es una factor regulador de la transcripci\u00F3n, que contiene tres sitios de dedos de zinc de uni\u00F3n al ADN, y se expresa en mayor medida en una poblaci\u00F3n de c\u00E9lulas migratorias de la cresta neural. M\u00E1s tarde se expresa en las c\u00E9lulas de los ganglios craneales derivadas de la cresta neural. La prote\u00EDna codificada por el Krox20 contiene dos dedos de zinc del tipo cys2his2. La expresi\u00F3n del gen Krox20 es exclusiva del desarrollo temprano del rombenc\u00E9falo. La evoluci\u00F3n la ha conservado en vertebrados, humanos, ratones, polluelos y peces cebra. Adem\u00E1s, la secuencia de amino\u00E1cidos y la mayor\u00EDa de los aspectos relativos al patr\u00F3n g\u00E9nico embrionario que se conservan entre los vertebrados juegan a posteriori un papel en el desarrollo del rombenc\u00E9falo. En el momento en el que se suprime el gen Krox20 en los ratones, su capacidad de codificaci\u00F3n de prote\u00EDnas (incluido el dominio de uni\u00F3n al ADN del dedo de zinc) disminuye. Estos ratones son incapaces de sobrevivir despu\u00E9s del nacimiento y presentan importantes defectos en el rombenc\u00E9falo. Estos defectos incluyen, entre otros, defectos en la formaci\u00F3n de los ganglios sensoriales craneales, fusi\u00F3n parcial del nervio trig\u00E9mino (V) con los nervios facial (VII) y auditivo (VII), las ra\u00EDces nerviosas proximales que salen de estos ganglios estaban desorganizadas y entrelazadas entre s\u00ED al entrar en el tronco cerebral, adem\u00E1s de existir fusi\u00F3n del complejo nervioso glosofar\u00EDngeo (IX)."@es . . . "EGR2 (\u0430\u043D\u0433\u043B. Early growth response 2) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 10-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 476 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 50 302. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u044F\u043C\u0438 \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u043B\u0456\u0433\u0430\u0437, \u0430\u043A\u0442\u0438\u0432\u0430\u0442\u043E\u0440\u0456\u0432. \u0417\u0430\u0434\u0456\u044F\u043D\u0438\u0439 \u0443 \u0442\u0430\u043A\u0438\u0445 \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u0438\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0430\u0445, \u044F\u043A \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u044F, \u0440\u0435\u0433\u0443\u043B\u044F\u0446\u0456\u044F \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u0457, \u0443\u0431\u0456\u043A\u0432\u0456\u0442\u0438\u043D\u0443\u0432\u0430\u043D\u043D\u044F \u0431\u0456\u043B\u043A\u0456\u0432, \u0430\u043B\u044C\u0442\u0435\u0440\u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u043F\u043B\u0430\u0439\u0441\u0438\u043D\u0433. \u0411\u0456\u043B\u043E\u043A \u043C\u0430\u0454 \u0441\u0430\u0439\u0442 \u0434\u043B\u044F \u0437\u0432'\u044F\u0437\u0443\u0432\u0430\u043D\u043D\u044F \u0437 \u0456\u043E\u043D\u0430\u043C\u0438 \u043C\u0435\u0442\u0430\u043B\u0456\u0432, \u0456\u043E\u043D\u043E\u043C \u0446\u0438\u043D\u043A\u0443, \u0414\u041D\u041A. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u044F\u0434\u0440\u0456."@uk . "Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells. It is later expressed in the neural crest derived cells of the cranial ganglion. The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early hindbrain development. It is evolutionarily conserved in vertebrates, humans, mice, chicks, and zebra fish. In addition, the amino acid sequence and most aspects of the embryonic gene pattern is conserved among vertebrates, further implicating its role in hindbrain development. When the Krox20 is deleted in mice, the prote"@en . "1116599349"^^ . . . . . . "\u65E9\u671F\u751F\u957F\u53CD\u5E94\u86CB\u767D2\uFF08\u82F1\u8A9E\uFF1AEarly growth response protein 2\uFF0CEGR-2\uFF09\u662F\u4E00\u4E2A\u7531\u4EBA\u7C7B\u57FA\u56E0EGR2\u7F16\u7801\u7684\u86CB\u767D\u8D28\u3002 EGR2\u662F\u4E00\u4E2A\u8F6C\u5F55\u56E0\u5B50\uFF0C\u5305\u542B\u4E09\u4E2A\u4E32\u8054\u7684Cys2His2\u578B\u950C\u6307\u7ED3\u6784\uFF0C\u8BE5\u57FA\u56E0\u7684\u591A\u6001\u6027\u4E0EI\u578B\u8FDB\u884C\u6027\u795E\u7ECF\u6027\u8153\u9AA8\u808C\u840E\u7F29\u75C7\u6709\u5173\u3002"@zh . . . . "EGR2"@en . . . . . . . . . . . . . . "EGR2 (\u0430\u043D\u0433\u043B. Early growth response 2) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 10-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 476 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 50 302. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D"@uk . "EGR2"@uk . . . . . . . .