. "EC50"@en . . "Als mittlere effektive Konzentration (EC50) bzw. mittlere effektive Dosis (ED50), wird in der Pharmakologie und Toxikologie die effektive Konzentration bzw. Dosis bezeichnet, bei der ein halbmaximaler Effekt beobachtet wird. Die mittlere Effektivdosis kann nicht direkt gemessen werden, sondern muss aus einer an einer Gruppe von Individuen bestimmten Dosis-Wirkungs-Kurve durch mathematische Modellierung abgeleitet werden. Bei der Toxizit\u00E4tsbestimmung entspricht die EC50 einer Konzentration, die bei 50 % einer Versuchspopulation eine andere definierte Wirkung als den Tod ausl\u00F6st \u2013 bei Letalit\u00E4t w\u00FCrde man von LC50 sprechen. In der \u00D6kotoxikologie beziehen sich EbC50 und ErC50 auf die Reduktion der Biomasse bzw. auf die Inhibition des Wachstums von Pflanzen oder Algen. In der Pharmakologie wird \u00FCber den Quotienten von LD50 und ED50 die Therapeutische Breite berechnet."@de . . "EC50, \u0430\u0431\u043E \u043D\u0430\u043F\u0456\u0432\u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u0430 \u0435\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u0430 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044F, \u043E\u0437\u043D\u0430\u0447\u0430\u0454 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044E \u043B\u0456\u0433\u0430\u043D\u0434\u0430, \u044F\u043A\u0430 \u0441\u043F\u0440\u0438\u0447\u0438\u043D\u044E\u0454 \u0435\u0444\u0435\u043A\u0442, \u0449\u043E \u0434\u043E\u0440\u0456\u0432\u043D\u044E\u0454 \u043F\u043E\u043B\u043E\u0432\u0438\u043D\u0456 \u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u043C\u043E\u0436\u043B\u0438\u0432\u043E\u0433\u043E \u0434\u043B\u044F \u0434\u0430\u043D\u043E\u0433\u043E \u043B\u0456\u0433\u0430\u043D\u0434\u0443 \u043F\u0456\u0441\u043B\u044F \u0441\u043F\u043B\u0438\u0432\u0430\u043D\u043D\u044F \u0434\u0435\u044F\u043A\u043E\u0433\u043E \u043F\u0440\u043E\u043C\u0456\u0436\u043A\u0443 \u0447\u0430\u0441\u0443. \u0426\u044F \u0432\u0435\u043B\u0438\u0447\u0438\u043D\u0430 \u0437\u0432\u0438\u0447\u0430\u0439\u043D\u043E \u0432\u0438\u043A\u043E\u0440\u0438\u0441\u0442\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u044F\u043A \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043A\u0430 \u043F\u043E\u0442\u0443\u0436\u043D\u043E\u0441\u0442\u0456 \u0434\u0456\u0457 \u043B\u0456\u0433\u0430\u043D\u0434\u0443. EC50 \u0433\u0440\u0430\u0434\u0443\u0439\u043E\u0432\u0430\u043D\u043E\u0457 \u043A\u0440\u0438\u0432\u043E\u0457 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044F-\u0435\u0444\u0435\u043A\u0442, \u0442\u0430\u043A\u0438\u043C \u0447\u0438\u043D\u043E\u043C, \u0440\u0435\u043F\u0440\u0435\u0437\u0435\u043D\u0442\u0443\u0454 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044E \u0441\u043F\u043E\u043B\u0443\u043A\u0438, \u043F\u0440\u0438 \u0434\u0456\u0457 \u044F\u043A\u043E\u0457 \u0441\u043F\u043E\u0441\u0442\u0435\u0440\u0456\u0433\u0430\u0454\u0442\u044C\u0441\u044F \u0435\u0444\u0435\u043A\u0442, \u0449\u043E \u0434\u043E\u0440\u0456\u0432\u043D\u044E\u0454 \u043F\u043E\u043B\u043E\u0432\u0438\u043D\u0456 \u0457\u0457 \u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0435\u0444\u0435\u043A\u0442\u0443; EC50 \u043A\u0432\u0430\u043D\u0442\u043E\u0432\u0430\u043D\u043E\u0457 \u043A\u0440\u0438\u0432\u043E\u0457 \u0434\u043E\u0437\u0430-\u0435\u0444\u0435\u043A\u0442 \u0440\u0435\u043F\u0440\u0435\u0437\u0435\u043D\u0442\u0443\u0454 \u043A\u043E\u043D\u0441\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044E \u0441\u043F\u043E\u043B\u0443\u043A\u0438, \u0449\u043E \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u043E\u0447\u0456\u043A\u0443\u0432\u0430\u043D\u0438\u0439 \u0435\u0444\u0435\u043A\u0442 \u0443 50% \u043E\u0441\u043E\u0431\u0438\u043D \u043F\u0456\u0434\u0434\u043E\u0441\u043B\u0456\u0434\u043D\u043E\u0457 \u043F\u043E\u043F\u0443\u043B\u044F\u0446\u0456\u0457."@uk . . . . . . . "La concentration efficace m\u00E9diane (CE50 ou EC50 en anglais) est une mesure de la concentration d'un m\u00E9dicament, d'un anticorps ou d'un toxique qui induit une r\u00E9ponse \u00E0 mi-chemin (m\u00E9diane) entre la ligne de base et l'effet maximum apr\u00E8s un certain temps d'exposition \u00E0 celui-ci. Elle est couramment utilis\u00E9e comme mesure de l'efficacit\u00E9 d'un m\u00E9dicament."@fr . "EC50\uFF08\u30A4\u30FC\u30B7\u30FC\u30D5\u30A3\u30D5\u30C6\u30A3\uFF09\u300150%\u52B9\u679C\u6FC3\u5EA6\uFF0850\u30D1\u30FC\u30BB\u30F3\u30C8\u3053\u3046\u304B\u306E\u3046\u3069\uFF09\u307E\u305F\u306F\u534A\u6570\u52B9\u679C\u6FC3\u5EA6\uFF08\u306F\u3093\u3059\u3046\u3053\u3046\u304B\u306E\u3046\u3069\uFF09\u3068\u306F\u3001\u85AC\u7269\u3084\u6297\u4F53\u306A\u3069\u304C\u6700\u4F4E\u5024\u304B\u3089\u306E\u6700\u5927\u53CD\u5FDC\u306E50%\u3092\u793A\u3059\u6FC3\u5EA6\u306E\u3053\u3068\u3092\u6307\u3059\u3002EC50\u306F\u5143\u6765\u82F1\u8A9E\u306E\"half maximal (50%) effective concentration\"\u306E\u7565\u8A9E\u3067\u3042\u308B\u304C\u3001\u73FE\u5728\u3067\u306FEC50\u306E\u8868\u8A18\u306E\u65B9\u304C\u4E00\u822C\u7684\u3067\u3042\u308B\u3002 EC50\u306F\u7279\u306B\u8840\u4E2D\u306B\u304A\u3051\u308B50%\u52B9\u679C\u6FC3\u5EA6\u3092\u6307\u3059\u3053\u3068\u3082\u3042\u308B\u3002\u3053\u306E\u5834\u5408\u3001\u6295\u4E0E\u91CF\u3068\u3057\u3066\u306FED50\uFF0850%\u52B9\u679C\u7528\u91CF\u3001\u534A\u6570\u52B9\u679C\u7528\u91CF\uFF09\u3092\u7528\u3044\u308B\u3002"@ja . . . . . . . "L'EC50 \u00E8 la concentrazione di un dato farmaco tale da produrre il 50% dell'effetto massimale. Essa rappresenta la potenza del farmaco, sicch\u00E9 \u00E8 plausibile affermare che tra pi\u00F9 farmaci interagenti con lo stesso sistema recettoriale \u00E8 pi\u00F9 potente quello dotato di minore EC50. Quest'ultimo, infatti, sar\u00E0 in grado di esplicare gli stessi effetti a concentrazioni inferiori. L'EC50 di un farmaco pu\u00F2 essere modificata in presenza di antagonisti. Gli antagonisti recettoriali competitivi determinano un aumento dell'EC50 con apparente riduzione di potenza del farmaco agonista. Questo vuol dire che l'inibizione provocata dall'antagonista verr\u00E0 sormontata aumentando le concentrazioni di agonista, il quale mantiene comunque la stessa efficacia e lo stesso effetto massimo ottenibile. Gli antagonisti recettoriali non competitivi, al contrario, non modificano l'EC50 in quanto l'inibizione non pu\u00F2 essere superata aumentando le concentrazioni di agonista. L'antagonista non competitivo riduce l'efficacia dell'agonista ma la potenza rimane invariata. Apparentemente si verifica una riduzione del numero di recettori. Gli antagonisti recettoriali competitivi sono invece farmaci privi di efficacia che stabiliscono un legame reversibile con il recettore. Non attivano il recettore ma esercitano un'azione di inibizione nei confronti del ligando naturale o del farmaco agonista. La loro attivit\u00E0 intrinseca \u00E8 nulla in quanto non mimano l'azione del ligando naturale."@it . "L'EC50 \u00E8 la concentrazione di un dato farmaco tale da produrre il 50% dell'effetto massimale. Essa rappresenta la potenza del farmaco, sicch\u00E9 \u00E8 plausibile affermare che tra pi\u00F9 farmaci interagenti con lo stesso sistema recettoriale \u00E8 pi\u00F9 potente quello dotato di minore EC50. Quest'ultimo, infatti, sar\u00E0 in grado di esplicare gli stessi effetti a concentrazioni inferiori."@it . "9029"^^ . . "3742950"^^ . "EC50 \u0438\u043B\u0438 \u043F\u043E\u043B\u0443\u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u0430\u044F \u044D\u0444\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u0430\u044F \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u044F, \u043E\u0437\u043D\u0430\u0447\u0430\u0435\u0442 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u044E \u043B\u0438\u0433\u0430\u043D\u0434\u0430, \u043A\u043E\u0442\u043E\u0440\u0430\u044F \u0432\u044B\u0437\u044B\u0432\u0430\u0435\u0442 \u044D\u0444\u0444\u0435\u043A\u0442, \u0440\u0430\u0432\u043D\u044B\u0439 \u043F\u043E\u043B\u043E\u0432\u0438\u043D\u0435 \u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0432\u043E\u0437\u043C\u043E\u0436\u043D\u043E\u0433\u043E \u0434\u043B\u044F \u0434\u0430\u043D\u043D\u043E\u0433\u043E \u043B\u0438\u0433\u0430\u043D\u0434\u0430 \u043F\u043E\u0441\u043B\u0435 \u0438\u0441\u0442\u0435\u0447\u0435\u043D\u0438\u044F \u043D\u0435\u043A\u043E\u0442\u043E\u0440\u043E\u0433\u043E \u043F\u0440\u043E\u043C\u0435\u0436\u0443\u0442\u043A\u0430 \u0432\u0440\u0435\u043C\u0435\u043D\u0438. \u0414\u0430\u043D\u043D\u0430\u044F \u0432\u0435\u043B\u0438\u0447\u0438\u043D\u0430 \u043E\u0431\u044B\u0447\u043D\u043E \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u0435\u0442\u0441\u044F \u0432 \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043A\u0438 \u043C\u043E\u0449\u043D\u043E\u0441\u0442\u0438 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u043B\u0438\u0433\u0430\u043D\u0434\u0430. EC50 \u0433\u0440\u0430\u0434\u0443\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u043E\u0439 \u043A\u0440\u0438\u0432\u043E\u0439 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u044F-\u044D\u0444\u0444\u0435\u043A\u0442, \u0442\u0430\u043A\u0438\u043C \u043E\u0431\u0440\u0430\u0437\u043E\u043C, \u043F\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043B\u044F\u0435\u0442 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u044E \u0441\u043E\u0435\u0434\u0438\u043D\u0435\u043D\u0438\u044F, \u043F\u0440\u0438 \u0432\u043E\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0438 \u043A\u043E\u0442\u043E\u0440\u043E\u0439 \u043D\u0430\u0431\u043B\u044E\u0434\u0430\u0435\u0442\u0441\u044F \u044D\u0444\u0444\u0435\u043A\u0442, \u0440\u0430\u0432\u043D\u044B\u0439 \u043F\u043E\u043B\u043E\u0432\u0438\u043D\u0435 \u0435\u0433\u043E \u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u044D\u0444\u0444\u0435\u043A\u0442\u0430; EC50 \u043A\u0432\u0430\u043D\u0442\u043E\u0432\u0430\u043D\u043D\u043E\u0439 \u043A\u0440\u0438\u0432\u043E\u0439 \u0434\u043E\u0437\u0430-\u044D\u0444\u0444\u0435\u043A\u0442 \u043F\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043B\u044F\u0435\u0442 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u044E \u0441\u043E\u0435\u0434\u0438\u043D\u0435\u043D\u0438\u044F, \u0447\u0442\u043E \u0432\u044B\u0437\u044B\u0432\u0430\u0435\u0442 \u043E\u0436\u0438\u0434\u0430\u0435\u043C\u044B\u0439 \u044D\u0444\u0444\u0435\u043A\u0442 \u0443 50 % \u043E\u0441\u043E\u0431\u0435\u0439 \u043F\u043E\u0434\u043E\u043F\u044B\u0442\u043D\u043E\u0439 \u043F\u043E\u043F\u0443\u043B\u044F\u0446\u0438\u0438. EC50 \u043E\u0431\u044B\u0447\u043D\u043E \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u0435\u0442\u0441\u044F \u043F\u0440\u0438 \u0438\u0441\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u043D\u0438\u0438 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u0430\u0433\u043E\u043D\u0438\u0441\u0442\u043E\u0432 \u0438\u043B\u0438 \u0441\u0442\u0438\u043C\u0443\u043B\u044F\u0442\u043E\u0440\u043E\u0432, \u0432 \u0442\u043E \u0432\u0440\u0435\u043C\u044F \u043A\u0430\u043A \u043F\u0440\u0438 \u0438\u0441\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u043D\u0438\u0438 \u044D\u0444\u0444\u0435\u043A\u0442\u043E\u0432 \u0430\u043D\u0442\u0430\u0433\u043E\u043D\u0438\u0441\u0442\u043E\u0432, \u0438\u043B\u0438 \u0438\u0441\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u043D\u0438\u0438 \u043A\u043E\u043D\u043A\u0443\u0440\u0435\u043D\u0442\u043D\u043E\u0433\u043E \u0432\u0437\u0430\u0438\u043C\u043E\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u0432\u0435\u0449\u0435\u0441\u0442\u0432, \u0447\u0430\u0449\u0435 \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u044E\u0442 \u0440\u043E\u0434\u0441\u0442\u0432\u0435\u043D\u043D\u044B\u0439 \u043F\u043E\u043A\u0430\u0437\u0430\u0442\u0435\u043B\u044C IC50. \u0417\u0430\u0432\u0438\u0441\u0438\u043C\u043E\u0441\u0442\u044C \u044D\u0444\u0444\u0435\u043A\u0442\u0430 \u043E\u0442 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u0438 \u043E\u0431\u044B\u0447\u043D\u043E \u043E\u043F\u0438\u0441\u044B\u0432\u0430\u0435\u0442\u0441\u044F \u0441\u0438\u0433\u043C\u043E\u0438\u0434\u043D\u043E\u0439 \u043A\u0440\u0438\u0432\u043E\u0439, \u0431\u044B\u0441\u0442\u0440\u043E \u0440\u0430\u0441\u0442\u0435\u0442 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C \u043F\u0440\u043E\u043C\u0435\u0436\u0443\u0442\u043A\u0435 \u0438\u0437\u043C\u0435\u043D\u0435\u043D\u0438\u044F \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u0439. \u0422\u043E\u0447\u043A\u0430 \u043F\u0435\u0440\u0435\u0433\u0438\u0431\u0430 \u044D\u0442\u043E\u0439 \u043A\u0440\u0438\u0432\u043E\u0439 \u0441\u043E\u0432\u043F\u0430\u0434\u0430\u0435\u0442 \u0441\u043E \u0437\u043D\u0430\u0447\u0435\u043D\u0438\u0435\u043C EC50 (\u0441\u043C. \u0440\u0438\u0441\u0443\u043D\u043E\u043A)."@ru . "EC50"@de . . . . . "EC50"@uk . "1098831267"^^ . "EC50"@pt . . . . . "EC50, \u0430\u0431\u043E \u043D\u0430\u043F\u0456\u0432\u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u0430 \u0435\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u0430 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044F, \u043E\u0437\u043D\u0430\u0447\u0430\u0454 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044E \u043B\u0456\u0433\u0430\u043D\u0434\u0430, \u044F\u043A\u0430 \u0441\u043F\u0440\u0438\u0447\u0438\u043D\u044E\u0454 \u0435\u0444\u0435\u043A\u0442, \u0449\u043E \u0434\u043E\u0440\u0456\u0432\u043D\u044E\u0454 \u043F\u043E\u043B\u043E\u0432\u0438\u043D\u0456 \u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u043C\u043E\u0436\u043B\u0438\u0432\u043E\u0433\u043E \u0434\u043B\u044F \u0434\u0430\u043D\u043E\u0433\u043E \u043B\u0456\u0433\u0430\u043D\u0434\u0443 \u043F\u0456\u0441\u043B\u044F \u0441\u043F\u043B\u0438\u0432\u0430\u043D\u043D\u044F \u0434\u0435\u044F\u043A\u043E\u0433\u043E \u043F\u0440\u043E\u043C\u0456\u0436\u043A\u0443 \u0447\u0430\u0441\u0443. \u0426\u044F \u0432\u0435\u043B\u0438\u0447\u0438\u043D\u0430 \u0437\u0432\u0438\u0447\u0430\u0439\u043D\u043E \u0432\u0438\u043A\u043E\u0440\u0438\u0441\u0442\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u044F\u043A \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043A\u0430 \u043F\u043E\u0442\u0443\u0436\u043D\u043E\u0441\u0442\u0456 \u0434\u0456\u0457 \u043B\u0456\u0433\u0430\u043D\u0434\u0443. EC50 \u0433\u0440\u0430\u0434\u0443\u0439\u043E\u0432\u0430\u043D\u043E\u0457 \u043A\u0440\u0438\u0432\u043E\u0457 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044F-\u0435\u0444\u0435\u043A\u0442, \u0442\u0430\u043A\u0438\u043C \u0447\u0438\u043D\u043E\u043C, \u0440\u0435\u043F\u0440\u0435\u0437\u0435\u043D\u0442\u0443\u0454 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044E \u0441\u043F\u043E\u043B\u0443\u043A\u0438, \u043F\u0440\u0438 \u0434\u0456\u0457 \u044F\u043A\u043E\u0457 \u0441\u043F\u043E\u0441\u0442\u0435\u0440\u0456\u0433\u0430\u0454\u0442\u044C\u0441\u044F \u0435\u0444\u0435\u043A\u0442, \u0449\u043E \u0434\u043E\u0440\u0456\u0432\u043D\u044E\u0454 \u043F\u043E\u043B\u043E\u0432\u0438\u043D\u0456 \u0457\u0457 \u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0435\u0444\u0435\u043A\u0442\u0443; EC50 \u043A\u0432\u0430\u043D\u0442\u043E\u0432\u0430\u043D\u043E\u0457 \u043A\u0440\u0438\u0432\u043E\u0457 \u0434\u043E\u0437\u0430-\u0435\u0444\u0435\u043A\u0442 \u0440\u0435\u043F\u0440\u0435\u0437\u0435\u043D\u0442\u0443\u0454 \u043A\u043E\u043D\u0441\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u044E \u0441\u043F\u043E\u043B\u0443\u043A\u0438, \u0449\u043E \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u043E\u0447\u0456\u043A\u0443\u0432\u0430\u043D\u0438\u0439 \u0435\u0444\u0435\u043A\u0442 \u0443 50% \u043E\u0441\u043E\u0431\u0438\u043D \u043F\u0456\u0434\u0434\u043E\u0441\u043B\u0456\u0434\u043D\u043E\u0457 \u043F\u043E\u043F\u0443\u043B\u044F\u0446\u0456\u0457. EC50 \u0437\u0432\u0438\u0447\u0430\u0439\u043D\u043E \u0432\u0438\u043A\u043E\u0440\u0438\u0441\u0442\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u043F\u0440\u0438 \u0434\u043E\u0441\u043B\u0456\u0434\u0436\u0435\u043D\u043D\u0456 \u0434\u0456\u0457 \u0430\u0433\u043E\u043D\u0456\u0441\u0442\u0456\u0432 \u0430\u0431\u043E \u0441\u0442\u0438\u043C\u0443\u043B\u044F\u0442\u043E\u0440\u0456\u0432, \u0432 \u0442\u043E\u0439 \u0447\u0430\u0441 \u044F\u043A \u043F\u0440\u0438 \u0434\u043E\u0441\u043B\u0456\u0434\u0436\u0435\u043D\u043D\u0456 \u0435\u0444\u0435\u043A\u0442\u0456\u0432 \u0430\u043D\u0442\u0430\u0433\u043E\u043D\u0456\u0441\u0442\u0456\u0432, \u0430\u0431\u043E \u0434\u043E\u0441\u043B\u0456\u0434\u0436\u0435\u043D\u043D\u0456 \u043A\u043E\u043D\u043A\u0443\u0440\u0435\u043D\u0442\u043D\u043E\u0457 \u0432\u0437\u0430\u0454\u043C\u043E\u0434\u0456\u0457 \u0440\u0435\u0447\u043E\u0432\u0438\u043D, \u0447\u0430\u0441\u0442\u0456\u0448\u0435 \u0432\u0438\u043A\u043E\u0440\u0438\u0441\u0442\u043E\u0432\u0443\u044E\u0442\u044C \u0441\u043F\u043E\u0440\u0456\u0434\u043D\u0435\u043D\u0438\u0439 \u043F\u043E\u043A\u0430\u0437\u043D\u0438\u043A IC50. \u0417\u0430\u043B\u0435\u0436\u043D\u0456\u0441\u0442\u044C \u0435\u0444\u0435\u043A\u0442\u0443 \u0432\u0456\u0434 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u0457 \u0437\u0432\u0438\u0447\u0430\u0439\u043D\u043E \u043E\u043F\u0438\u0441\u0443\u0454\u0442\u044C\u0441\u044F \u0441\u0438\u0433\u043C\u043E\u0457\u0434\u043D\u043E\u044E \u043A\u0440\u0438\u0432\u043E\u044E, \u0449\u043E \u0448\u0432\u0438\u0434\u043A\u043E \u0437\u0440\u043E\u0441\u0442\u0430\u0454 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u0440\u043E\u043C\u0456\u0436\u043A\u0443 \u0437\u043C\u0456\u043D\u0438 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0456\u0439. \u0422\u043E\u0447\u043A\u0430 \u043F\u0435\u0440\u0435\u0433\u0438\u043D\u0443 \u0446\u0456\u0454\u0457 \u043A\u0440\u0438\u0432\u043E\u0457 \u0437\u0431\u0456\u0433\u0430\u0454\u0442\u044C\u0441\u044F \u0456\u0437 \u0437\u043D\u0430\u0447\u0435\u043D\u043D\u044F\u043C EC50 (\u0434\u0438\u0432. \u0440\u0438\u0441\u0443\u043D\u043E\u043A)."@uk . . . . . "Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time. More simply, EC50 can be defined as the concentration required to obtain a 50% [...] effect and may be also written as [A]50. It is commonly used as a measure of a drug's potency, although the use of EC50 is preferred over that of 'potency', which has been criticised for its vagueness. EC50 is a measure of concentration, expressed in molar units (M), where 1 M is equivalent to 1 mol/L."@en . . . . "A concentra\u00E7\u00E3o do f\u00E1rmaco que induz metade do efeito m\u00E1ximo (EC50) refere-se \u00E0 concentra\u00E7\u00E3o na qual uma droga, anticorpo ou toxina induz uma resposta na metade entre a taxa inicial e a m\u00E1xima ap\u00F3s um tempo especificado de exposi\u00E7\u00E3o. \u00C9 usada normalmente como medida da pot\u00EAncia de uma droga O EC50 de uma curva de dose-resposta graduada representa a concentra\u00E7\u00E3o do composto para qual 50% do efeito \u00E9 observado.O EC50 de uma curva de dose-reposta quantal representa a concentra\u00E7\u00E3o para qual 50% da popula\u00E7\u00E3o exibe uma resposta, ap\u00F3s uma dura\u00E7\u00E3o de exposi\u00E7\u00E3o especificada."@pt . . "EC50"@it . . "Concentration efficace m\u00E9diane"@fr . . . . . . "A concentra\u00E7\u00E3o do f\u00E1rmaco que induz metade do efeito m\u00E1ximo (EC50) refere-se \u00E0 concentra\u00E7\u00E3o na qual uma droga, anticorpo ou toxina induz uma resposta na metade entre a taxa inicial e a m\u00E1xima ap\u00F3s um tempo especificado de exposi\u00E7\u00E3o. \u00C9 usada normalmente como medida da pot\u00EAncia de uma droga O EC50 de uma curva de dose-resposta graduada representa a concentra\u00E7\u00E3o do composto para qual 50% do efeito \u00E9 observado.O EC50 de uma curva de dose-reposta quantal representa a concentra\u00E7\u00E3o para qual 50% da popula\u00E7\u00E3o exibe uma resposta, ap\u00F3s uma dura\u00E7\u00E3o de exposi\u00E7\u00E3o especificada. Ele \u00E9 tamb\u00E9m relacionado com o IC50, que \u00E9 uma media da inibi\u00E7\u00E3o de um composto (50% de inibi\u00E7\u00E3o). Para ensaios de liga\u00E7\u00E3o competitiva e ensaios de agonistas funcionais, o IC50 \u00E9 a medi\u00E7\u00E3o sum\u00E1ria mais comum da curva de dose-reposta. Para ensaios de agonista/estimulador a medi\u00E7\u00E3o sum\u00E1ria mais comum \u00E9 o EC50. Uma pequena mudan\u00E7a na concentra\u00E7\u00E3o de ligante tipicamente resulta em mudan\u00E7as r\u00E1picas em sistemas biol\u00F3gicos, seguindo uma fun\u00E7\u00E3o sigmoidal .O ponto de inflex\u00E3o no qual o aumento na resposta com aumento na concentra\u00E7\u00E3o de ligante come\u00E7a a diminuir \u00E9 o EC50, que pode ser determinado matematicamente como uma deriva\u00E7\u00E3o dada linha de correla\u00E7\u00E3o. Enquanto contar com um gr\u00E1fico para estimativas \u00E9 mais conveniente, esse m\u00E9todo t\u00EDpico rende resultados menos acurados e menos precisos. Existe uma variedade de valores de EC 50 para medicamentos, expresso atrav\u00E9s de unidades molares (M), onde M \u00E9 um equivalente de 1 mol / L. Portanto, \u00E9 muitas vezes mais pr\u00E1tico referir-se aos valores logaritmicamente transformados (p EC 50) em vez de apenas EC 50 :"@pt . "La concentration efficace m\u00E9diane (CE50 ou EC50 en anglais) est une mesure de la concentration d'un m\u00E9dicament, d'un anticorps ou d'un toxique qui induit une r\u00E9ponse \u00E0 mi-chemin (m\u00E9diane) entre la ligne de base et l'effet maximum apr\u00E8s un certain temps d'exposition \u00E0 celui-ci. Elle est couramment utilis\u00E9e comme mesure de l'efficacit\u00E9 d'un m\u00E9dicament. La CE50 d'une courbe dose-effet repr\u00E9sente donc la concentration d'un compos\u00E9 o\u00F9 50 % de l'effet maximal est observ\u00E9. La CE50 d'une courbe dose-effet quantique repr\u00E9sente la concentration d'un compos\u00E9 o\u00F9 50 % de la population pr\u00E9sente une r\u00E9ponse, apr\u00E8s une dur\u00E9e d'exposition sp\u00E9cifi\u00E9e. Elle est \u00E9galement li\u00E9e \u00E0 la CI50 qui est une mesure de l'inhibition d'un compos\u00E9 (50 % d'inhibition). Pour des tests fonctionnels d'un antagoniste et des tests de liaison concurrente, la CI50 est la mesure la plus courante de la courbe dose-effet. Pour des tests agonistes/de stimulation, c'est la CE50. Les mesures en fonction de la concentration suivent g\u00E9n\u00E9ralement une courbe sigmo\u00EFde, l'effet augmentant rapidement au cours d'un changement relativement faible de concentration. Le point o\u00F9 l'efficacit\u00E9 commence \u00E0 diminuer (point d'inflexion), malgr\u00E9 des concentrations croissantes, est la CE50. Celle-ci peut \u00EAtre d\u00E9termin\u00E9e math\u00E9matiquement \u00E0 l'aide d'une droite de meilleur ajustement. Bien que se baser sur un graphique pour l'estimation soit le plus pratique, les r\u00E9sultats en sont moins pr\u00E9cis et corrects."@fr . "EC50"@ja . "EC50"@ru . . . . . . "Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time. More simply, EC50 can be defined as the concentration required to obtain a 50% [...] effect and may be also written as [A]50. It is commonly used as a measure of a drug's potency, although the use of EC50 is preferred over that of 'potency', which has been criticised for its vagueness. EC50 is a measure of concentration, expressed in molar units (M), where 1 M is equivalent to 1 mol/L. The EC50 of a graded dose response curve therefore represents the concentration of a compound where 50% of its maximal effect is observed. The EC50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects. A quantal dose response curve shows the percentage of subjects where a response is noted in an all-or-none manner (y axis) over the dose of the drug (x axis). For competition binding assays and functional antagonist assays IC50 is the most common summary measure of the dose-response curve. For agonist/stimulator assays the most common summary measure is the EC50. The EC50 is also related to IC50 which is a measure of a compound's inhibition (50% inhibition)."@en . . . "EC50 \u0438\u043B\u0438 \u043F\u043E\u043B\u0443\u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u0430\u044F \u044D\u0444\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u0430\u044F \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u044F, \u043E\u0437\u043D\u0430\u0447\u0430\u0435\u0442 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0430\u0446\u0438\u044E \u043B\u0438\u0433\u0430\u043D\u0434\u0430, \u043A\u043E\u0442\u043E\u0440\u0430\u044F \u0432\u044B\u0437\u044B\u0432\u0430\u0435\u0442 \u044D\u0444\u0444\u0435\u043A\u0442, \u0440\u0430\u0432\u043D\u044B\u0439 \u043F\u043E\u043B\u043E\u0432\u0438\u043D\u0435 \u043C\u0430\u043A\u0441\u0438\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0432\u043E\u0437\u043C\u043E\u0436\u043D\u043E\u0433\u043E \u0434\u043B\u044F \u0434\u0430\u043D\u043D\u043E\u0433\u043E \u043B\u0438\u0433\u0430\u043D\u0434\u0430 \u043F\u043E\u0441\u043B\u0435 \u0438\u0441\u0442\u0435\u0447\u0435\u043D\u0438\u044F \u043D\u0435\u043A\u043E\u0442\u043E\u0440\u043E\u0433\u043E \u043F\u0440\u043E\u043C\u0435\u0436\u0443\u0442\u043A\u0430 \u0432\u0440\u0435\u043C\u0435\u043D\u0438. \u0414\u0430\u043D\u043D\u0430\u044F \u0432\u0435\u043B\u0438\u0447\u0438\u043D\u0430 \u043E\u0431\u044B\u0447\u043D\u043E \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u0435\u0442\u0441\u044F \u0432 \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043A\u0438 \u043C\u043E\u0449\u043D\u043E\u0441\u0442\u0438 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u043B\u0438\u0433\u0430\u043D\u0434\u0430. EC50 \u043E\u0431\u044B\u0447\u043D\u043E \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u0435\u0442\u0441\u044F \u043F\u0440\u0438 \u0438\u0441\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u043D\u0438\u0438 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u0430\u0433\u043E\u043D\u0438\u0441\u0442\u043E\u0432 \u0438\u043B\u0438 \u0441\u0442\u0438\u043C\u0443\u043B\u044F\u0442\u043E\u0440\u043E\u0432, \u0432 \u0442\u043E \u0432\u0440\u0435\u043C\u044F \u043A\u0430\u043A \u043F\u0440\u0438 \u0438\u0441\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u043D\u0438\u0438 \u044D\u0444\u0444\u0435\u043A\u0442\u043E\u0432 \u0430\u043D\u0442\u0430\u0433\u043E\u043D\u0438\u0441\u0442\u043E\u0432, \u0438\u043B\u0438 \u0438\u0441\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u043D\u0438\u0438 \u043A\u043E\u043D\u043A\u0443\u0440\u0435\u043D\u0442\u043D\u043E\u0433\u043E \u0432\u0437\u0430\u0438\u043C\u043E\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u0432\u0435\u0449\u0435\u0441\u0442\u0432, \u0447\u0430\u0449\u0435 \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u044E\u0442 \u0440\u043E\u0434\u0441\u0442\u0432\u0435\u043D\u043D\u044B\u0439 \u043F\u043E\u043A\u0430\u0437\u0430\u0442\u0435\u043B\u044C IC50."@ru . . . . . . "EC50\uFF08\u30A4\u30FC\u30B7\u30FC\u30D5\u30A3\u30D5\u30C6\u30A3\uFF09\u300150%\u52B9\u679C\u6FC3\u5EA6\uFF0850\u30D1\u30FC\u30BB\u30F3\u30C8\u3053\u3046\u304B\u306E\u3046\u3069\uFF09\u307E\u305F\u306F\u534A\u6570\u52B9\u679C\u6FC3\u5EA6\uFF08\u306F\u3093\u3059\u3046\u3053\u3046\u304B\u306E\u3046\u3069\uFF09\u3068\u306F\u3001\u85AC\u7269\u3084\u6297\u4F53\u306A\u3069\u304C\u6700\u4F4E\u5024\u304B\u3089\u306E\u6700\u5927\u53CD\u5FDC\u306E50%\u3092\u793A\u3059\u6FC3\u5EA6\u306E\u3053\u3068\u3092\u6307\u3059\u3002EC50\u306F\u5143\u6765\u82F1\u8A9E\u306E\"half maximal (50%) effective concentration\"\u306E\u7565\u8A9E\u3067\u3042\u308B\u304C\u3001\u73FE\u5728\u3067\u306FEC50\u306E\u8868\u8A18\u306E\u65B9\u304C\u4E00\u822C\u7684\u3067\u3042\u308B\u3002 EC50\u306F\u7279\u306B\u8840\u4E2D\u306B\u304A\u3051\u308B50%\u52B9\u679C\u6FC3\u5EA6\u3092\u6307\u3059\u3053\u3068\u3082\u3042\u308B\u3002\u3053\u306E\u5834\u5408\u3001\u6295\u4E0E\u91CF\u3068\u3057\u3066\u306FED50\uFF0850%\u52B9\u679C\u7528\u91CF\u3001\u534A\u6570\u52B9\u679C\u7528\u91CF\uFF09\u3092\u7528\u3044\u308B\u3002 EC50\u306F\u4E00\u822C\u306B\u533B\u85AC\u54C1\u306E\u6709\u52B9\u5EA6\u3092\u793A\u3059\u305F\u3081\u306B\u7528\u3044\u3089\u308C\u308B\u3002\u52B9\u679C\u306E\u7A0B\u5EA6\u304C\u9023\u7D9A\u7684\u306B\u8A08\u6E2C\u3067\u304D\u308B\u3088\u3046\u306A\uFF08\u4F8B\u3048\u3070\u3001\u5FC3\u62CD\u6570\u306B\u5F71\u97FF\u3092\u53CA\u307C\u3059\u3088\u3046\u306A\uFF09\u85AC\u5264\u306E\u7528\u91CF\u53CD\u5FDC\u66F2\u7DDA\u306EEC50\u306F\u3001\u6700\u5927\u53CD\u5FDC\u306E50\uFF05\u306E\u53CD\u5FDC\u5F37\u5EA6\u3092\u793A\u3059\u5316\u5408\u7269\u306E\u6FC3\u5EA6\u3092\u8868\u3057\u3066\u3044\u308B\u3002\u4E00\u65B9\u3001\u52B9\u679C\u304C\u73FE\u308C\u308B\u304B\u73FE\u308C\u306A\u3044\u304B\u3067\u306E\u307F\u8A55\u4FA1\u3067\u304D\u308B\u85AC\u5264\uFF08\u4F8B\u3048\u3070\u6297\u3066\u3093\u304B\u3093\u85AC\uFF09\u306E\u7528\u91CF\u53CD\u5FDC\u66F2\u7DDA\u306EEC50\u306F\u3001\u8A66\u9A13\u3055\u308C\u305F\u6BCD\u96C6\u56E3\u306E\u3046\u306150%\u306E\u500B\u4F53\u304C\u53CD\u5FDC\u3092\u793A\u3059\u5316\u5408\u7269\u306E\u6FC3\u5EA6\u3092\u8868\u3057\u3066\u3044\u308B\u3002EC50\u306F\u85AC\u7269\u306E\u963B\u5BB3\u80FD\u306E\u5C3A\u5EA6\u3067\u3042\u308BIC50\u3068\u3082\u95A2\u9023\u3057\u3066\u3044\u308B\u3002\u7AF6\u5408\u7D50\u5408\u8A55\u4FA1\u3068\u6A5F\u80FD\u7684\u30A2\u30F3\u30BF\u30B4\u30CB\u30B9\u30C8\u8A55\u4FA1\u306E\u305F\u3081\u306B\u306FIC50\u304C\u7528\u91CF\u53CD\u5FDC\u66F2\u7DDA\u306E\u6700\u3082\u4E00\u822C\u7684\u306A\u96C6\u7D04\u5C3A\u5EA6\u3067\u3042\u308A\u3001\u30A2\u30B4\u30CB\u30B9\u30C8/\u4FC3\u9032\u5264\u8A55\u4FA1\u306B\u306FEC50\u304C\u6700\u3082\u4E00\u822C\u7684\u3067\u3042\u308B\u3002\u7528\u91CF\u53CD\u5FDC\u66F2\u7DDA\u306F\u901A\u5E38\u3001\u5C11\u3057\u306E\u6FC3\u5EA6\u306E\u5909\u5316\u306B\u5BFE\u3057\u3066\u52B9\u679C\u304C\u6025\u306B\u7ACB\u3061\u4E0A\u304C\u308A\u3084\u304C\u3066\u52B9\u679C\u306E\u5897\u52A0\u304C\u9045\u304F\u306A\u3063\u3066\u3086\u304F\u3001\u3044\u308F\u3086\u308B\u30B7\u30B0\u30E2\u30A4\u30C9\u66F2\u7DDA\u306E\u5F62\u72B6\u3092\u6210\u3059\u3002\u6FC3\u5EA6\u306E\u5897\u52A0\u306B\u5BFE\u3057\u3066\u52B9\u679C\u306E\u5897\u52A0\u304C\u9045\u304F\u306A\u308B\u70B9\uFF08\u5909\u66F2\u70B9\uFF09\u304CIC50\u3067\u3042\u308B\u3002\u6E2C\u5B9A\u5024\u306B\u5BFE\u3057\u3066\u6700\u9069\u306A\u8FD1\u4F3C\u66F2\u7DDA\u3092\u6570\u5B66\u7684\u306B\u5C0E\u304F\u3053\u3068\u3067IC50\u304C\u6C42\u3081\u3089\u308C\u308B\u3002"@ja . "Als mittlere effektive Konzentration (EC50) bzw. mittlere effektive Dosis (ED50), wird in der Pharmakologie und Toxikologie die effektive Konzentration bzw. Dosis bezeichnet, bei der ein halbmaximaler Effekt beobachtet wird. Die mittlere Effektivdosis kann nicht direkt gemessen werden, sondern muss aus einer an einer Gruppe von Individuen bestimmten Dosis-Wirkungs-Kurve durch mathematische Modellierung abgeleitet werden. In der \u00D6kotoxikologie beziehen sich EbC50 und ErC50 auf die Reduktion der Biomasse bzw. auf die Inhibition des Wachstums von Pflanzen oder Algen."@de . .